FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802170010> ?p ?o ?g. }

• W2802170010 endingPage "290" @default.
• W2802170010 startingPage "282" @default.
• W2802170010 abstract "Ovarian cancer (OC) is one of the leading causes of death for female cancer patients. COC166-9 is an OC-specific monoclonal antibody and we have identified immunoglobulin γ-1 heavy chain constant region (IGHG1) as its antigen. We explore the function of IGHG1 in proliferation, apoptosis and motility of OC cells further in this research.IGHG1 expression in OC specimens was detected through immunohistochemistry. Real-time quantitative polymerase chain reaction (RT-qPCR) or western blotting assay was used to test IGHG1 expression in OC cells. Viability of OC cells was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Flow cytometry or western blotting assay was used to detect cell cycle and apoptosis. Cellular motility was analyzed by using transwell assay and the markers of epithelial-mesenchymal transition (EMT) were tested through immunoblots.Although it exerts negligible effect on the viability and apoptosis of OC cells, IGHG1 could promote migration and invasion of malignant cells in vitro. Mechanistically, IGHG1 increases the expression of N-cadherin and Vimentin while decreases E-cadherin expression. Additionally, IGHG1 expression in OC specimens is higher relative to the paired normal counterparts. Further analysis demonstrates that the increased IGHG1 expression correlates positively with the lymph node metastasis of OC.IGHG1 promotes the motility of OC cells likely through executing the EMT program. Increased IGHG1 expression in OC specimens is associated with the lymph node metastasis." @default.
• W2802170010 created "2018-05-17" @default.
• W2802170010 creator A5002180447 @default.
• W2802170010 creator A5003256933 @default.
• W2802170010 creator A5003697485 @default.
• W2802170010 creator A5018080543 @default.
• W2802170010 creator A5021506689 @default.
• W2802170010 creator A5043542554 @default.
• W2802170010 creator A5047153226 @default.
• W2802170010 creator A5082816879 @default.
• W2802170010 date "2018-01-01" @default.
• W2802170010 modified "2023-09-25" @default.
• W2802170010 title "IGHG1 promotes motility likely through epithelial-mesenchymal transition in ovarian cancer" @default.
• W2802170010 cites W1499021562 @default.
• W2802170010 cites W1512694675 @default.
• W2802170010 cites W1942694849 @default.
• W2802170010 cites W1966932597 @default.
• W2802170010 cites W1976992968 @default.
• W2802170010 cites W1991242976 @default.
• W2802170010 cites W2036015352 @default.
• W2802170010 cites W2043228552 @default.
• W2802170010 cites W2071656930 @default.
• W2802170010 cites W2079484912 @default.
• W2802170010 cites W2089048368 @default.
• W2802170010 cites W2120841541 @default.
• W2802170010 cites W2127379638 @default.
• W2802170010 cites W2154317529 @default.
• W2802170010 cites W2163225870 @default.
• W2802170010 cites W2163843128 @default.
• W2802170010 cites W2291430342 @default.
• W2802170010 cites W2397749779 @default.
• W2802170010 cites W2405269240 @default.
• W2802170010 cites W2411383835 @default.
• W2802170010 cites W2570618306 @default.
• W2802170010 cites W2591724574 @default.
• W2802170010 cites W2917837889 @default.
• W2802170010 cites W3141540903 @default.
• W2802170010 cites W3144431626 @default.
• W2802170010 doi "https://doi.org/10.21147/j.issn.1000-9604.2018.02.11" @default.
• W2802170010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5953964" @default.
• W2802170010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29861613" @default.
• W2802170010 hasPublicationYear "2018" @default.
• W2802170010 type Work @default.
• W2802170010 sameAs 2802170010 @default.
• W2802170010 citedByCount "8" @default.
• W2802170010 countsByYear W28021700102019 @default.
• W2802170010 countsByYear W28021700102020 @default.
• W2802170010 countsByYear W28021700102021 @default.
• W2802170010 countsByYear W28021700102022 @default.
• W2802170010 countsByYear W28021700102023 @default.
• W2802170010 crossrefType "journal-article" @default.
• W2802170010 hasAuthorship W2802170010A5002180447 @default.
• W2802170010 hasAuthorship W2802170010A5003256933 @default.
• W2802170010 hasAuthorship W2802170010A5003697485 @default.
• W2802170010 hasAuthorship W2802170010A5018080543 @default.
• W2802170010 hasAuthorship W2802170010A5021506689 @default.
• W2802170010 hasAuthorship W2802170010A5043542554 @default.
• W2802170010 hasAuthorship W2802170010A5047153226 @default.
• W2802170010 hasAuthorship W2802170010A5082816879 @default.
• W2802170010 hasBestOaLocation W28021700102 @default.
• W2802170010 hasConcept C104317684 @default.
• W2802170010 hasConcept C121608353 @default.
• W2802170010 hasConcept C147447768 @default.
• W2802170010 hasConcept C153911025 @default.
• W2802170010 hasConcept C190283241 @default.
• W2802170010 hasConcept C203014093 @default.
• W2802170010 hasConcept C204232928 @default.
• W2802170010 hasConcept C2779013556 @default.
• W2802170010 hasConcept C2780427987 @default.
• W2802170010 hasConcept C2780783641 @default.
• W2802170010 hasConcept C502942594 @default.
• W2802170010 hasConcept C53227056 @default.
• W2802170010 hasConcept C54355233 @default.
• W2802170010 hasConcept C553184892 @default.
• W2802170010 hasConcept C55493867 @default.
• W2802170010 hasConcept C58207958 @default.
• W2802170010 hasConcept C76419328 @default.
• W2802170010 hasConcept C85265743 @default.
• W2802170010 hasConcept C86803240 @default.
• W2802170010 hasConcept C95444343 @default.
• W2802170010 hasConceptScore W2802170010C104317684 @default.
• W2802170010 hasConceptScore W2802170010C121608353 @default.
• W2802170010 hasConceptScore W2802170010C147447768 @default.
• W2802170010 hasConceptScore W2802170010C153911025 @default.
• W2802170010 hasConceptScore W2802170010C190283241 @default.
• W2802170010 hasConceptScore W2802170010C203014093 @default.
• W2802170010 hasConceptScore W2802170010C204232928 @default.
• W2802170010 hasConceptScore W2802170010C2779013556 @default.
• W2802170010 hasConceptScore W2802170010C2780427987 @default.
• W2802170010 hasConceptScore W2802170010C2780783641 @default.
• W2802170010 hasConceptScore W2802170010C502942594 @default.
• W2802170010 hasConceptScore W2802170010C53227056 @default.
• W2802170010 hasConceptScore W2802170010C54355233 @default.
• W2802170010 hasConceptScore W2802170010C553184892 @default.
• W2802170010 hasConceptScore W2802170010C55493867 @default.
• W2802170010 hasConceptScore W2802170010C58207958 @default.
• W2802170010 hasConceptScore W2802170010C76419328 @default.
• W2802170010 hasConceptScore W2802170010C85265743 @default.

• next