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• W2802174468 abstract "No AccessJournal of UrologyAdult Urology1 Sep 2018Inflatable Penile Prosthesis Placement, Scratch Technique and Postoperative Vacuum Therapy as a Combined Approach to Definitive Treatment of Peyronie’s Disease Gabriele Antonini, Ettore De Berardinis, Francesco Del Giudice, Gian Maria Busetto, Stefano Lauretti, Ramiro Fragas, Benjamin I. Chung, Simon L. Conti, Diana Giannarelli, Isabella Sperduti, Martin S. Gross, and Paul E. Perito Gabriele AntoniniGabriele Antonini Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy More articles by this author , Ettore De BerardinisEttore De Berardinis Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy More articles by this author , Francesco Del GiudiceFrancesco Del Giudice Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy More articles by this author , Gian Maria BusettoGian Maria Busetto Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy More articles by this author , Stefano LaurettiStefano Lauretti Department of Urology, Santa Caterina della Rosa Clinic ASL RM-C, Rome, Italy More articles by this author , Ramiro FragasRamiro Fragas Clinica Central Cira Garcia, La Havana, Cuba More articles by this author , Benjamin I. ChungBenjamin I. Chung Department of Urology, Stanford University Medical Center, Stanford, California More articles by this author , Simon L. ContiSimon L. Conti Department of Urology, Stanford University Medical Center, Stanford, California More articles by this author , Diana GiannarelliDiana Giannarelli Biostatistical Unit, Regina Elena National Cancer Institute, Rome, Italy More articles by this author , Isabella SperdutiIsabella Sperduti Biostatistical Unit, Regina Elena National Cancer Institute, Rome, Italy More articles by this author , Martin S. GrossMartin S. Gross Section of Urology, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire Financial interest and/or other relationship with Coloplast. More articles by this author , and Paul E. PeritoPaul E. Perito Department of Urology, Coral Gables Hospital, Coral Gables, Florida More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2018.04.060AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Peyronie’s disease is a devastating condition resulting in penile malformation, erectile dysfunction, pain and emotional distress. In this prospective, 2 institution study we evaluated a multimodal surgical and mechanical combined approach to the definitive treatment of Peyronie’s disease and concomitant erectile dysfunction. Materials and Methods: A total of 145 select patients underwent endocavernous disruption of Peyronie’s disease plaques via the scratch technique, followed by inflatable penile prosthesis insertion. Postoperatively patients were assigned to vacuum device therapy for 3 minutes twice daily to continue penile curvature correction. Followup continued for 1 year after surgery. Anatomical and functional results were assessed. Results: Patients with plaques in the proximal third, middle third and subcoronal areas of the penis had a mean ± SD postoperative residual curvature of 21.5 ± 4.5, 17.3 ± 4.8 and 14.1 ± 3.1 degrees, respectively. After 24 weeks of vacuum therapy the mean penile curvature deviation decreased to 8.7 ± 2.5, 9.1 ± 2.9 and 7.7 ± 0.9 degrees, respectively. The mean IIEF-5 (International Index of Erectile Function) score was 9.8 ± 2.3 preoperatively, 18.9 ± 3.1 at 6 months (p <0.001) and 24.1 ± 3.6 at 1 year (p <0.001). The mean EDITS (Erectile Dysfunction Inventory of Treatment Satisfaction) score at the end of followup was 64.6 ± 11.8. Operative and postoperative complications were minimal. Conclusions: Our novel combination of intraoperative and postoperative therapies in the treatment of patients with Peyronie’s disease and an inflatable penile prosthesis was safe and efficacious with excellent functional outcomes. Penile curvature corrections were statistically significant and complications were negligible. © 2018 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails References 1 : An analysis of the natural history of Peyronie's disease. J Urol2006; 175: 2115. Link, Google Scholar 2 : The prevalence of Peyronie’s disease in the United States: a population-based study. PLoS One2016; 11: e0150157. Google Scholar 3 : The prevalence of Peyronie’s disease: results of a large survey. BJU Int2001; 88: 727. Google Scholar 4 : Prevalence of Peyronie’s disease in men over 50-y-old from southern Brazil. Int J Impot Res2001; 13: 291. Google Scholar 5 : Proposal: trauma as the cause of the Peyronie’s lesion. J Urol1997; 157: 285. 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Google Scholar Cited bySeftel A (2019) Re: Prevalence of Penile Curvature: A Population-Based Cross-Sectional Study in Metropolitan and Rural Cities in AustraliaJournal of Urology, VOL. 202, NO. 1, (13-14), Online publication date: 1-Jul-2019.Seftel A (2019) Re: Combined Plaque Incision, Buccal Mucosa Grafting, and Additional Tunica Albuginea Plication for Peyronie’s DiseaseJournal of Urology, VOL. 201, NO. 6, (1038-1038), Online publication date: 1-Jun-2019.Seftel A (2019) Re: Penile Size Restoration with Nondegloving Approach for Peyronie's Disease: Initial ExperienceJournal of Urology, VOL. 201, NO. 4, (650-651), Online publication date: 1-Apr-2019.Seftel A (2019) Re: Penile Sensory Changes after Plaque Incision and Grafting Surgery for Peyronie's DiseaseJournal of Urology, VOL. 201, NO. 4, (650-650), Online publication date: 1-Apr-2019.Seftel A (2019) Re: Plication for Severe Peyronie's Deformities has Similar Long-Term Outcomes to Milder CasesJournal of Urology, VOL. 201, NO. 4, (649-650), Online publication date: 1-Apr-2019.Seftel A (2019) Re: Patient Perspectives on Peyronie's Disease: Results of Poststudy Interviews from a Phase 2 Trial of Collagenase Clostridium histolyticumJournal of Urology, VOL. 201, NO. 4, (649-649), Online publication date: 1-Apr-2019.Seftel A (2019) Re: Sildenafil 25 mg ODT + Collagenase Clostridium Hystoliticum vs Collagenase Clostridium Hystoliticum Alone for the Management of Peyronie's Disease: A Matched-Pair Comparison AnalysisJournal of Urology, VOL. 201, NO. 2, (211-211), Online publication date: 1-Feb-2019.Seftel A (2018) Re: Reduction in Peyronie’s-Like Plaque Size Using a Vacuum Erection Device in a Rat Model of Peyronie’s Disease via the TGF-β/SMAD Signalling PathwayJournal of Urology, VOL. 200, NO. 6, (1146-1148), Online publication date: 1-Dec-2018.Seftel A (2018) Re: Patient’s Choice of Health Information and Treatment Modality for Peyronie’s Disease: A Long-Term AssessmentJournal of Urology, VOL. 200, NO. 5, (929-929), Online publication date: 1-Nov-2018.Seftel A (2018) Re: Plaque Calcification: An Important Predictor of Collagenase Clostridium Histolyticum Treatment Outcomes for Men with Peyronie’s DiseaseJournal of Urology, VOL. 200, NO. 5, (928-928), Online publication date: 1-Nov-2018.Seftel A (2018) Re: Introducing the Ventral Sealing Technique Using Collagen Fleece for Surgical Therapy of Patients with Ventral Peyronie’s Curvature: Initial ExperienceJournal of Urology, VOL. 200, NO. 5, (928-928), Online publication date: 1-Nov-2018. Volume 200Issue 3September 2018Page: 642-647Supplementary Materials Advertisement Copyright & Permissions© 2018 by American Urological Association Education and Research, Inc.Keywordspatient reported outcome measurestissue expansion devicesmaleurologic surgical procedurespenile prosthesispenile indurationMetrics See more details Twitter (13) Facebook (1) Mendeley (20) Author Information Gabriele Antonini Department of Urology, Sapienza Rome University, Policlinico Umberto I, Rome, Italy More articles by this author … View all authors Expand All Advertisement PDF downloadLoading ..." @default.
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• W2802174468 title "Inflatable Penile Prosthesis Placement, Scratch Technique and Postoperative Vacuum Therapy as a Combined Approach to Definitive Treatment of Peyronie’s Disease" @default.
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