FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802203710> ?p ?o ?g. }

• W2802203710 endingPage "1159" @default.
• W2802203710 startingPage "1146" @default.
• W2802203710 abstract "Substrate stiffness is known to alter cell behavior and drive stem cell differentiation, though most research in this area has been restricted to traditional, two-dimensional culture systems rather than more physiologically relevant, three-dimensional (3D) platforms. In this study, we utilized polymer-based, cell mimicking microparticles (CMMPs) to deliver distinct, stable mechanical cues to human adipose derived stem cells in 3D spheroid culture to examine changes in adipogenic differentiation response and mechanophenotype. After 21 days of adipogenic induction, spheroids containing CMMPs (composite spheroids) stiffened in accordance with CMMP elasticity such that spheroids containing the stiffest, ~ 10 kPa, CMMPs were over 27% stiffer than those incorporating the most compliant, ~ 0.25 kPa CMMPs. Adipogenically induced, cell-only spheroids were over 180% larger and 50% more compliant than matched controls. Interestingly, composite spheroids cultured without chemical induction factors dissociated when presented with CMMPs stiffer than ~ 1 kPa, while adipogenic induction factors mitigated this behavior. Gene expression for PPARG and FABP4 were upregulated more than 45-fold in adipogenically induced samples compared to controls but were unaffected by CMMP elasticity, attributed to insufficient cell-CMMP contacts throughout the composite spheroid. In summary, mechanically tuned CMMPs influenced whole-spheroid mechanophenotype and stability but minimally affected differentiation response." @default.
• W2802203710 created "2018-05-17" @default.
• W2802203710 creator A5025567115 @default.
• W2802203710 creator A5035637008 @default.
• W2802203710 creator A5053646968 @default.
• W2802203710 creator A5054959711 @default.
• W2802203710 creator A5066899145 @default.
• W2802203710 date "2018-04-18" @default.
• W2802203710 modified "2023-10-11" @default.
• W2802203710 title "Cell Mimicking Microparticles Influence the Organization, Growth, and Mechanophenotype of Stem Cell Spheroids" @default.
• W2802203710 cites W1587510658 @default.
• W2802203710 cites W1964681850 @default.
• W2802203710 cites W1972006944 @default.
• W2802203710 cites W1977894565 @default.
• W2802203710 cites W1983227327 @default.
• W2802203710 cites W1984685797 @default.
• W2802203710 cites W1987400820 @default.
• W2802203710 cites W1990677265 @default.
• W2802203710 cites W2007944348 @default.
• W2802203710 cites W2008260566 @default.
• W2802203710 cites W2018028722 @default.
• W2802203710 cites W2021972578 @default.
• W2802203710 cites W2032128101 @default.
• W2802203710 cites W2043585992 @default.
• W2802203710 cites W2043634767 @default.
• W2802203710 cites W2052612687 @default.
• W2802203710 cites W2067981767 @default.
• W2802203710 cites W2068294198 @default.
• W2802203710 cites W2068467751 @default.
• W2802203710 cites W2071375023 @default.
• W2802203710 cites W2091140665 @default.
• W2802203710 cites W2100454719 @default.
• W2802203710 cites W2111427334 @default.
• W2802203710 cites W2113547540 @default.
• W2802203710 cites W2121752173 @default.
• W2802203710 cites W2124817079 @default.
• W2802203710 cites W2134208433 @default.
• W2802203710 cites W2144023435 @default.
• W2802203710 cites W2148328620 @default.
• W2802203710 cites W2154555172 @default.
• W2802203710 cites W2159778842 @default.
• W2802203710 cites W2165134887 @default.
• W2802203710 cites W2224935128 @default.
• W2802203710 cites W2270498673 @default.
• W2802203710 cites W2560662407 @default.
• W2802203710 cites W2582805839 @default.
• W2802203710 cites W2608262603 @default.
• W2802203710 cites W2783867808 @default.
• W2802203710 doi "https://doi.org/10.1007/s10439-018-2028-4" @default.
• W2802203710 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6039261" @default.
• W2802203710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29671154" @default.
• W2802203710 hasPublicationYear "2018" @default.
• W2802203710 type Work @default.
• W2802203710 sameAs 2802203710 @default.
• W2802203710 citedByCount "12" @default.
• W2802203710 countsByYear W28022037102019 @default.
• W2802203710 countsByYear W28022037102020 @default.
• W2802203710 countsByYear W28022037102021 @default.
• W2802203710 countsByYear W28022037102022 @default.
• W2802203710 countsByYear W28022037102023 @default.
• W2802203710 crossrefType "journal-article" @default.
• W2802203710 hasAuthorship W2802203710A5025567115 @default.
• W2802203710 hasAuthorship W2802203710A5035637008 @default.
• W2802203710 hasAuthorship W2802203710A5053646968 @default.
• W2802203710 hasAuthorship W2802203710A5054959711 @default.
• W2802203710 hasAuthorship W2802203710A5066899145 @default.
• W2802203710 hasBestOaLocation W28022037102 @default.
• W2802203710 hasConcept C104317684 @default.
• W2802203710 hasConcept C121854251 @default.
• W2802203710 hasConcept C122927707 @default.
• W2802203710 hasConcept C12554922 @default.
• W2802203710 hasConcept C136229726 @default.
• W2802203710 hasConcept C148738053 @default.
• W2802203710 hasConcept C1491633281 @default.
• W2802203710 hasConcept C159985019 @default.
• W2802203710 hasConcept C175369904 @default.
• W2802203710 hasConcept C185592680 @default.
• W2802203710 hasConcept C192562407 @default.
• W2802203710 hasConcept C198826908 @default.
• W2802203710 hasConcept C28328180 @default.
• W2802203710 hasConcept C54355233 @default.
• W2802203710 hasConcept C55493867 @default.
• W2802203710 hasConcept C62112901 @default.
• W2802203710 hasConcept C71924100 @default.
• W2802203710 hasConcept C81885089 @default.
• W2802203710 hasConcept C86803240 @default.
• W2802203710 hasConcept C95444343 @default.
• W2802203710 hasConceptScore W2802203710C104317684 @default.
• W2802203710 hasConceptScore W2802203710C121854251 @default.
• W2802203710 hasConceptScore W2802203710C122927707 @default.
• W2802203710 hasConceptScore W2802203710C12554922 @default.
• W2802203710 hasConceptScore W2802203710C136229726 @default.
• W2802203710 hasConceptScore W2802203710C148738053 @default.
• W2802203710 hasConceptScore W2802203710C1491633281 @default.
• W2802203710 hasConceptScore W2802203710C159985019 @default.
• W2802203710 hasConceptScore W2802203710C175369904 @default.
• W2802203710 hasConceptScore W2802203710C185592680 @default.
• W2802203710 hasConceptScore W2802203710C192562407 @default.

• next