Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802207675> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2802207675 abstract "Therapeutic drug monitoring may be crucial in selected clinical conditions for the management of HIV infection. In recent years, new antiretrovirals have been introduced and in particular elvitegravir (EVG) is now recommended for first-line and simplification treatment as well as dolutegravir (DTG) and rilpivirine (RPV). The aim of this study was to develop and validate a high-performance liquid chromatography-ultraviolet (HPLC-UV) method for determining EVG and new antiretrovirals DTG and RPV in human plasma. Solid-phase extraction was applied to a 600 μL plasma sample. Chromatographic separation of the three drugs and internal standard was achieved with a gradient of acetonitrile and phosphate buffer on a C18 reverse-phase analytical column with a 20 min analytical run time. EVG and DTG were detected at 265 nm and RPV at 290 nm. Mean intra- and inter-day precisions were < 10%; the mean accuracy was <15%. Extraction recovery ranged between 105 and 82% for the drugs analyzed. Calibration curves were optimized according to the expected ranges of drug concentrations in patients; the coefficient of determination was >0.997 for all drugs. This method allows for monitoring EVG, DTG and RPV in the plasma of HIV-positive patients using HPLC-UV." @default.
- W2802207675 created "2018-05-17" @default.
- W2802207675 creator A5032359240 @default.
- W2802207675 creator A5046391214 @default.
- W2802207675 creator A5050125028 @default.
- W2802207675 creator A5063748250 @default.
- W2802207675 creator A5075357953 @default.
- W2802207675 creator A5076836884 @default.
- W2802207675 creator A5083437175 @default.
- W2802207675 creator A5087221790 @default.
- W2802207675 date "2018-05-31" @default.
- W2802207675 modified "2023-10-17" @default.
- W2802207675 title "Development and validation of an HPLC-UV method for quantification of elvitegravir and two other new antiretrovirals, dolutegravir and rilpivirine, in the plasma of HIV-positive patients" @default.
- W2802207675 cites W1509307283 @default.
- W2802207675 cites W1521837913 @default.
- W2802207675 cites W1983608029 @default.
- W2802207675 cites W2003473457 @default.
- W2802207675 cites W2042664299 @default.
- W2802207675 cites W2316546164 @default.
- W2802207675 cites W2319787546 @default.
- W2802207675 cites W2369824948 @default.
- W2802207675 cites W2406931452 @default.
- W2802207675 cites W2583744239 @default.
- W2802207675 cites W2741865307 @default.
- W2802207675 doi "https://doi.org/10.1002/bmc.4274" @default.
- W2802207675 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29726595" @default.
- W2802207675 hasPublicationYear "2018" @default.
- W2802207675 type Work @default.
- W2802207675 sameAs 2802207675 @default.
- W2802207675 citedByCount "8" @default.
- W2802207675 countsByYear W28022076752020 @default.
- W2802207675 countsByYear W28022076752021 @default.
- W2802207675 countsByYear W28022076752022 @default.
- W2802207675 countsByYear W28022076752023 @default.
- W2802207675 crossrefType "journal-article" @default.
- W2802207675 hasAuthorship W2802207675A5032359240 @default.
- W2802207675 hasAuthorship W2802207675A5046391214 @default.
- W2802207675 hasAuthorship W2802207675A5050125028 @default.
- W2802207675 hasAuthorship W2802207675A5063748250 @default.
- W2802207675 hasAuthorship W2802207675A5075357953 @default.
- W2802207675 hasAuthorship W2802207675A5076836884 @default.
- W2802207675 hasAuthorship W2802207675A5083437175 @default.
- W2802207675 hasAuthorship W2802207675A5087221790 @default.
- W2802207675 hasConcept C112705442 @default.
- W2802207675 hasConcept C142462285 @default.
- W2802207675 hasConcept C159047783 @default.
- W2802207675 hasConcept C179998833 @default.
- W2802207675 hasConcept C185592680 @default.
- W2802207675 hasConcept C2777068322 @default.
- W2802207675 hasConcept C2778723075 @default.
- W2802207675 hasConcept C2779502633 @default.
- W2802207675 hasConcept C2779778239 @default.
- W2802207675 hasConcept C2780272996 @default.
- W2802207675 hasConcept C2780404665 @default.
- W2802207675 hasConcept C2993143319 @default.
- W2802207675 hasConcept C3013748606 @default.
- W2802207675 hasConcept C43617362 @default.
- W2802207675 hasConcept C71924100 @default.
- W2802207675 hasConcept C81426234 @default.
- W2802207675 hasConcept C98274493 @default.
- W2802207675 hasConceptScore W2802207675C112705442 @default.
- W2802207675 hasConceptScore W2802207675C142462285 @default.
- W2802207675 hasConceptScore W2802207675C159047783 @default.
- W2802207675 hasConceptScore W2802207675C179998833 @default.
- W2802207675 hasConceptScore W2802207675C185592680 @default.
- W2802207675 hasConceptScore W2802207675C2777068322 @default.
- W2802207675 hasConceptScore W2802207675C2778723075 @default.
- W2802207675 hasConceptScore W2802207675C2779502633 @default.
- W2802207675 hasConceptScore W2802207675C2779778239 @default.
- W2802207675 hasConceptScore W2802207675C2780272996 @default.
- W2802207675 hasConceptScore W2802207675C2780404665 @default.
- W2802207675 hasConceptScore W2802207675C2993143319 @default.
- W2802207675 hasConceptScore W2802207675C3013748606 @default.
- W2802207675 hasConceptScore W2802207675C43617362 @default.
- W2802207675 hasConceptScore W2802207675C71924100 @default.
- W2802207675 hasConceptScore W2802207675C81426234 @default.
- W2802207675 hasConceptScore W2802207675C98274493 @default.
- W2802207675 hasIssue "9" @default.
- W2802207675 hasLocation W28022076751 @default.
- W2802207675 hasLocation W28022076752 @default.
- W2802207675 hasOpenAccess W2802207675 @default.
- W2802207675 hasPrimaryLocation W28022076751 @default.
- W2802207675 hasRelatedWork W2133594819 @default.
- W2802207675 hasRelatedWork W2325222779 @default.
- W2802207675 hasRelatedWork W2766387703 @default.
- W2802207675 hasRelatedWork W2770961921 @default.
- W2802207675 hasRelatedWork W2906129695 @default.
- W2802207675 hasRelatedWork W2940215033 @default.
- W2802207675 hasRelatedWork W3000281717 @default.
- W2802207675 hasRelatedWork W3016565612 @default.
- W2802207675 hasRelatedWork W3183734642 @default.
- W2802207675 hasRelatedWork W4214955136 @default.
- W2802207675 hasVolume "32" @default.
- W2802207675 isParatext "false" @default.
- W2802207675 isRetracted "false" @default.
- W2802207675 magId "2802207675" @default.
- W2802207675 workType "article" @default.