Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802208785> ?p ?o ?g. }
- W2802208785 endingPage "83" @default.
- W2802208785 startingPage "79" @default.
- W2802208785 abstract "It has been shown in both human and mouse placentas that follicle stimulating hormone receptor (FSHR) is expressed in fetal vascular endothelium. There are conflicting reports, however, on the role of FSH to stimulate angiogenesis in vitro in cultured endothelial cells from umbilical veins. Therefore, in this study we undertook an in vivo approach utilizing Fshr null mice to definitively address this question. In the context where all pregnant dams have identical Fshr genotypes, we generated fetuses and associated fetal portions of placenta that were Fshr wt or Fshr null and analyzed angiogenesis within the placental labyrinths. Quantitative morphometric analyses of placentas obtained at mid-gestation revealed that the percentage of the placenta composed of labyrinth is significantly decreased in Fshr null placentas relative to wt placentas. Furthermore, data presented demonstrate that within the Fshr null labyrinths, fetal vessel angiogenesis was significantly reduced relative to wt labyrinths. The results obtained with this combination of in vivo and genetic approaches conclusively demonstrate that signaling through endothelial FSHR does indeed stimulate angiogenesis and that placental Fshr is essential for normal angiogenesis of the fetal placental vasculature." @default.
- W2802208785 created "2018-05-17" @default.
- W2802208785 creator A5001556393 @default.
- W2802208785 creator A5035015014 @default.
- W2802208785 date "2018-11-01" @default.
- W2802208785 modified "2023-10-02" @default.
- W2802208785 title "Deletion of fetoplacental Fshr inhibits fetal vessel angiogenesis in the mouse placenta" @default.
- W2802208785 cites W1529306536 @default.
- W2802208785 cites W176140244 @default.
- W2802208785 cites W1774553629 @default.
- W2802208785 cites W1943376726 @default.
- W2802208785 cites W1965463560 @default.
- W2802208785 cites W1978695171 @default.
- W2802208785 cites W1984970610 @default.
- W2802208785 cites W1990583906 @default.
- W2802208785 cites W1990795536 @default.
- W2802208785 cites W1999554798 @default.
- W2802208785 cites W2000679047 @default.
- W2802208785 cites W2018690108 @default.
- W2802208785 cites W2026726238 @default.
- W2802208785 cites W2027813788 @default.
- W2802208785 cites W2029992524 @default.
- W2802208785 cites W2044487543 @default.
- W2802208785 cites W2044752015 @default.
- W2802208785 cites W2045752787 @default.
- W2802208785 cites W2047837749 @default.
- W2802208785 cites W2052036741 @default.
- W2802208785 cites W2064543792 @default.
- W2802208785 cites W2066322705 @default.
- W2802208785 cites W2074400318 @default.
- W2802208785 cites W2075616541 @default.
- W2802208785 cites W2076480166 @default.
- W2802208785 cites W2077596106 @default.
- W2802208785 cites W2084990460 @default.
- W2802208785 cites W2085466965 @default.
- W2802208785 cites W2092948999 @default.
- W2802208785 cites W2096204842 @default.
- W2802208785 cites W2105544539 @default.
- W2802208785 cites W2109204766 @default.
- W2802208785 cites W2112201740 @default.
- W2802208785 cites W2114741486 @default.
- W2802208785 cites W2127222493 @default.
- W2802208785 cites W2127597540 @default.
- W2802208785 cites W2140322167 @default.
- W2802208785 cites W2143609597 @default.
- W2802208785 cites W2146181521 @default.
- W2802208785 cites W2153533622 @default.
- W2802208785 cites W2157999278 @default.
- W2802208785 cites W2160151670 @default.
- W2802208785 cites W2161158639 @default.
- W2802208785 cites W2164002837 @default.
- W2802208785 cites W2164683872 @default.
- W2802208785 cites W2171740008 @default.
- W2802208785 cites W2218760605 @default.
- W2802208785 cites W2234556095 @default.
- W2802208785 cites W2407743148 @default.
- W2802208785 cites W2473840809 @default.
- W2802208785 cites W2554725152 @default.
- W2802208785 cites W2775421362 @default.
- W2802208785 doi "https://doi.org/10.1016/j.mce.2018.04.011" @default.
- W2802208785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6120782" @default.
- W2802208785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29715497" @default.
- W2802208785 hasPublicationYear "2018" @default.
- W2802208785 type Work @default.
- W2802208785 sameAs 2802208785 @default.
- W2802208785 citedByCount "8" @default.
- W2802208785 countsByYear W28022087852018 @default.
- W2802208785 countsByYear W28022087852019 @default.
- W2802208785 countsByYear W28022087852020 @default.
- W2802208785 countsByYear W28022087852023 @default.
- W2802208785 crossrefType "journal-article" @default.
- W2802208785 hasAuthorship W2802208785A5001556393 @default.
- W2802208785 hasAuthorship W2802208785A5035015014 @default.
- W2802208785 hasBestOaLocation W28022087851 @default.
- W2802208785 hasConcept C126322002 @default.
- W2802208785 hasConcept C134018914 @default.
- W2802208785 hasConcept C151730666 @default.
- W2802208785 hasConcept C16685009 @default.
- W2802208785 hasConcept C172680121 @default.
- W2802208785 hasConcept C2776953305 @default.
- W2802208785 hasConcept C2778575703 @default.
- W2802208785 hasConcept C2779234561 @default.
- W2802208785 hasConcept C2779279165 @default.
- W2802208785 hasConcept C2779343474 @default.
- W2802208785 hasConcept C2780394083 @default.
- W2802208785 hasConcept C2780899479 @default.
- W2802208785 hasConcept C29390026 @default.
- W2802208785 hasConcept C502942594 @default.
- W2802208785 hasConcept C54355233 @default.
- W2802208785 hasConcept C71315377 @default.
- W2802208785 hasConcept C71924100 @default.
- W2802208785 hasConcept C86803240 @default.
- W2802208785 hasConceptScore W2802208785C126322002 @default.
- W2802208785 hasConceptScore W2802208785C134018914 @default.
- W2802208785 hasConceptScore W2802208785C151730666 @default.
- W2802208785 hasConceptScore W2802208785C16685009 @default.
- W2802208785 hasConceptScore W2802208785C172680121 @default.
- W2802208785 hasConceptScore W2802208785C2776953305 @default.