FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802227235> ?p ?o ?g. }

• W2802227235 endingPage "1422" @default.
• W2802227235 startingPage "1413" @default.
• W2802227235 abstract "Background: The success of increasing access to antiretroviral therapy (ART) in paediatric HIV infection prompts the question of the potential for eradication of HIV infection in this age group. ‘Shock-and-kill’ HIV cure approaches, currently in development, may depend upon an effective antiviral T-cell response to eradicate virus-infected cells. Method: We here investigate the ability of HIV-infected children receiving ART from early childhood (median 24 months’ age) to generate effective HIV-specific CD4+ and CD8+ T-cell immune responses that would facilitate future immune-based cure therapies. Results: Initial analysis of ART-naive HIV-infected children demonstrated that maintenance of normal-for-age absolute CD4+ T-cell counts was strongly linked to high IL-2 production and polyfunctional HIV-specific CD4+ T-cell responses (P < 0.0001 in each case). Low viral load was, similarly, strongly associated with markedly low IFN-γ and high IL-2 HIV-specific CD4+ T-cell responses (P < 0.0001). In children receiving ART, establishment of this immune profile (high IL-2 and low IFN-γ HIV-specific T-cell production) was strongly related to the duration of viraemic suppression. Failure to suppress viraemia on ART, and even the successful suppression of viraemia interrupted by the occurrence of transient viraemia of more than 1000 HIV copies/ml, was associated with an immune profile of high IFN-γ and low IL-2 HIV-specific T-cell responses and low polyfunctionality. Conclusion: These data are consistent with recovery of functional CD4+ T-cell responses in ART-treated children, in contrast to relative lack of CD4+ T-cell function recovery described in ART-treated adults. However, the challenges of achieving long-term suppression of viraemia in ART-treated children through adolescence remain daunting." @default.
• W2802227235 created "2018-05-17" @default.
• W2802227235 creator A5004709847 @default.
• W2802227235 creator A5008361747 @default.
• W2802227235 creator A5012277518 @default.
• W2802227235 creator A5018523831 @default.
• W2802227235 creator A5023339596 @default.
• W2802227235 creator A5042081819 @default.
• W2802227235 creator A5043346206 @default.
• W2802227235 creator A5054812318 @default.
• W2802227235 creator A5066040108 @default.
• W2802227235 creator A5074085845 @default.
• W2802227235 creator A5082537383 @default.
• W2802227235 date "2018-07-17" @default.
• W2802227235 modified "2023-09-28" @default.
• W2802227235 title "Recovery of effective HIV-specific CD4+ T-cell activity following antiretroviral therapy in paediatric infection requires sustained suppression of viraemia" @default.
• W2802227235 cites W109731274 @default.
• W2802227235 cites W1489568724 @default.
• W2802227235 cites W1494122660 @default.
• W2802227235 cites W1527202588 @default.
• W2802227235 cites W1597248718 @default.
• W2802227235 cites W1612382123 @default.
• W2802227235 cites W1910012553 @default.
• W2802227235 cites W1943288924 @default.
• W2802227235 cites W1965983343 @default.
• W2802227235 cites W1969501741 @default.
• W2802227235 cites W1974355146 @default.
• W2802227235 cites W1978436252 @default.
• W2802227235 cites W1980004115 @default.
• W2802227235 cites W1981480494 @default.
• W2802227235 cites W1983042663 @default.
• W2802227235 cites W2016987589 @default.
• W2802227235 cites W2029722878 @default.
• W2802227235 cites W2037343680 @default.
• W2802227235 cites W2037524921 @default.
• W2802227235 cites W2045796964 @default.
• W2802227235 cites W2047298095 @default.
• W2802227235 cites W2054480633 @default.
• W2802227235 cites W2064554628 @default.
• W2802227235 cites W2068200417 @default.
• W2802227235 cites W2071474112 @default.
• W2802227235 cites W2075919610 @default.
• W2802227235 cites W2089034023 @default.
• W2802227235 cites W2093979189 @default.
• W2802227235 cites W2105035124 @default.
• W2802227235 cites W2110155246 @default.
• W2802227235 cites W2110278919 @default.
• W2802227235 cites W2111839809 @default.
• W2802227235 cites W2112475246 @default.
• W2802227235 cites W2123061620 @default.
• W2802227235 cites W2126397165 @default.
• W2802227235 cites W2126952925 @default.
• W2802227235 cites W2129257965 @default.
• W2802227235 cites W2129457251 @default.
• W2802227235 cites W2130415530 @default.
• W2802227235 cites W2130560337 @default.
• W2802227235 cites W2160925670 @default.
• W2802227235 cites W2194273732 @default.
• W2802227235 cites W2298006045 @default.
• W2802227235 cites W2527222363 @default.
• W2802227235 cites W2614796239 @default.
• W2802227235 doi "https://doi.org/10.1097/qad.0000000000001844" @default.
• W2802227235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6039399" @default.
• W2802227235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29734220" @default.
• W2802227235 hasPublicationYear "2018" @default.
• W2802227235 type Work @default.
• W2802227235 sameAs 2802227235 @default.
• W2802227235 citedByCount "8" @default.
• W2802227235 countsByYear W28022272352019 @default.
• W2802227235 countsByYear W28022272352020 @default.
• W2802227235 countsByYear W28022272352021 @default.
• W2802227235 countsByYear W28022272352022 @default.
• W2802227235 crossrefType "journal-article" @default.
• W2802227235 hasAuthorship W2802227235A5004709847 @default.
• W2802227235 hasAuthorship W2802227235A5008361747 @default.
• W2802227235 hasAuthorship W2802227235A5012277518 @default.
• W2802227235 hasAuthorship W2802227235A5018523831 @default.
• W2802227235 hasAuthorship W2802227235A5023339596 @default.
• W2802227235 hasAuthorship W2802227235A5042081819 @default.
• W2802227235 hasAuthorship W2802227235A5043346206 @default.
• W2802227235 hasAuthorship W2802227235A5054812318 @default.
• W2802227235 hasAuthorship W2802227235A5066040108 @default.
• W2802227235 hasAuthorship W2802227235A5074085845 @default.
• W2802227235 hasAuthorship W2802227235A5082537383 @default.
• W2802227235 hasBestOaLocation W28022272352 @default.
• W2802227235 hasConcept C142462285 @default.
• W2802227235 hasConcept C159047783 @default.
• W2802227235 hasConcept C167672396 @default.
• W2802227235 hasConcept C203014093 @default.
• W2802227235 hasConcept C2522874641 @default.
• W2802227235 hasConcept C2776090121 @default.
• W2802227235 hasConcept C2780648854 @default.
• W2802227235 hasConcept C2993143319 @default.
• W2802227235 hasConcept C3013748606 @default.
• W2802227235 hasConcept C71924100 @default.
• W2802227235 hasConcept C86803240 @default.
• W2802227235 hasConcept C8891405 @default.
• W2802227235 hasConceptScore W2802227235C142462285 @default.

• next