Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802240459> ?p ?o ?g. }
- W2802240459 endingPage "83" @default.
- W2802240459 startingPage "76" @default.
- W2802240459 abstract "Pathological fractures caused by osteolytic lesions seriously threaten the health of patients. Osteoclasts play important roles in bone resorption whose hyperfunction are closely related to osteolytic lesions. Studies on osteoclast differentiation and function assist in the prevention of excessive bone loss associated diseases. We screened a variety of natural compounds with anti-inflammatory effect and found that poria cocos polysaccharide (PCP) inhibited RANKL-induced osteoclast formation and bone resorption via TRAcP staining, immunofluorescence, RT-PCR and western blot. PCP down-regulated phosphorylation of STAT3, P38, ERK and JNK, and thus repressed the expression of NFAcT1 and c-Fos during RANKL-induced osteoclastogenesis. Besides, the expression of bone resorption related genes such as TRAcP and CTSK was suppressed by PCP. The results suggest that PCP can be invoked as a candidate for the treatment of osteolytic diseases by inhibiting osteoclastogenesis." @default.
- W2802240459 created "2018-05-17" @default.
- W2802240459 creator A5034626208 @default.
- W2802240459 creator A5038366505 @default.
- W2802240459 creator A5040755656 @default.
- W2802240459 creator A5044825462 @default.
- W2802240459 creator A5046788364 @default.
- W2802240459 creator A5048599738 @default.
- W2802240459 creator A5055838753 @default.
- W2802240459 creator A5056044419 @default.
- W2802240459 creator A5070570063 @default.
- W2802240459 creator A5076637933 @default.
- W2802240459 date "2018-06-01" @default.
- W2802240459 modified "2023-10-16" @default.
- W2802240459 title "Poria cocos polysaccharide attenuates RANKL-induced osteoclastogenesis by suppressing NFATc1 activity and phosphorylation of ERK and STAT3" @default.
- W2802240459 cites W10697216 @default.
- W2802240459 cites W1750213494 @default.
- W2802240459 cites W1958938070 @default.
- W2802240459 cites W1959904772 @default.
- W2802240459 cites W1967502057 @default.
- W2802240459 cites W1976922262 @default.
- W2802240459 cites W1984623413 @default.
- W2802240459 cites W1988434255 @default.
- W2802240459 cites W1990714462 @default.
- W2802240459 cites W1994665945 @default.
- W2802240459 cites W1999568000 @default.
- W2802240459 cites W2009227200 @default.
- W2802240459 cites W2017372504 @default.
- W2802240459 cites W2030462394 @default.
- W2802240459 cites W2042303782 @default.
- W2802240459 cites W2047169413 @default.
- W2802240459 cites W2047682018 @default.
- W2802240459 cites W2048299560 @default.
- W2802240459 cites W2054596895 @default.
- W2802240459 cites W2063746249 @default.
- W2802240459 cites W2071766773 @default.
- W2802240459 cites W2079669233 @default.
- W2802240459 cites W2089678050 @default.
- W2802240459 cites W2114003326 @default.
- W2802240459 cites W2131136431 @default.
- W2802240459 cites W2140473585 @default.
- W2802240459 cites W2152388024 @default.
- W2802240459 cites W2178797777 @default.
- W2802240459 cites W2215407483 @default.
- W2802240459 cites W2236756986 @default.
- W2802240459 cites W2327074443 @default.
- W2802240459 cites W2330722106 @default.
- W2802240459 cites W2385771750 @default.
- W2802240459 cites W2531070662 @default.
- W2802240459 cites W2565099834 @default.
- W2802240459 cites W2593190152 @default.
- W2802240459 cites W2605004374 @default.
- W2802240459 cites W2606113946 @default.
- W2802240459 cites W2632691655 @default.
- W2802240459 cites W2735525238 @default.
- W2802240459 cites W2743936030 @default.
- W2802240459 cites W2748075817 @default.
- W2802240459 cites W4237593632 @default.
- W2802240459 cites W4292820908 @default.
- W2802240459 cites W2067152386 @default.
- W2802240459 doi "https://doi.org/10.1016/j.abb.2018.04.011" @default.
- W2802240459 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29678628" @default.
- W2802240459 hasPublicationYear "2018" @default.
- W2802240459 type Work @default.
- W2802240459 sameAs 2802240459 @default.
- W2802240459 citedByCount "17" @default.
- W2802240459 countsByYear W28022404592018 @default.
- W2802240459 countsByYear W28022404592019 @default.
- W2802240459 countsByYear W28022404592020 @default.
- W2802240459 countsByYear W28022404592021 @default.
- W2802240459 countsByYear W28022404592022 @default.
- W2802240459 countsByYear W28022404592023 @default.
- W2802240459 crossrefType "journal-article" @default.
- W2802240459 hasAuthorship W2802240459A5034626208 @default.
- W2802240459 hasAuthorship W2802240459A5038366505 @default.
- W2802240459 hasAuthorship W2802240459A5040755656 @default.
- W2802240459 hasAuthorship W2802240459A5044825462 @default.
- W2802240459 hasAuthorship W2802240459A5046788364 @default.
- W2802240459 hasAuthorship W2802240459A5048599738 @default.
- W2802240459 hasAuthorship W2802240459A5055838753 @default.
- W2802240459 hasAuthorship W2802240459A5056044419 @default.
- W2802240459 hasAuthorship W2802240459A5070570063 @default.
- W2802240459 hasAuthorship W2802240459A5076637933 @default.
- W2802240459 hasBestOaLocation W28022404592 @default.
- W2802240459 hasConcept C104317684 @default.
- W2802240459 hasConcept C11960822 @default.
- W2802240459 hasConcept C134018914 @default.
- W2802240459 hasConcept C146562846 @default.
- W2802240459 hasConcept C159654299 @default.
- W2802240459 hasConcept C185592680 @default.
- W2802240459 hasConcept C199343813 @default.
- W2802240459 hasConcept C202751555 @default.
- W2802240459 hasConcept C203014093 @default.
- W2802240459 hasConcept C2776033226 @default.
- W2802240459 hasConcept C2776415932 @default.
- W2802240459 hasConcept C2778236600 @default.
- W2802240459 hasConcept C2779428903 @default.
- W2802240459 hasConcept C2781282405 @default.