Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802240813> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2802240813 endingPage "317" @default.
- W2802240813 startingPage "291" @default.
- W2802240813 abstract "The manufacturing synthesis of omarigliptin used an improved convergent scheme. The original convergent synthesis of omarigliptin involved the coupling of methylsulfonylpyrrolopyrazole 14 and tetrahydropyranone 22. The omarigliptin used for clinical trials was a white crystalline material (confirmed by optical microscopy and X-ray powder diffraction (XRPD)). This chapter presents key physicochemical properties of omarigliptin. In clinical studies omarigliptin was shown to have a biphasic pharmacokinetic (PK) profile with a terminal half-life of 120 h that is adequate for once-weekly dosing. In the corresponding pharmacodynamic (PD) assay, omarigliptin-mediated plasma dipeptidylpeptidase-4 (DPP-4) inhibition and plasma compound concentrations were dose dependent. A counter screen evaluation in 168radio ligand binding and enzymatic assays at MDS Pharma confirmed the compound's selectivity as a DPP-4 inhibitor. Exposure to omarigliptin shows linear PK with respect to time and dose proportional at dose range between 10 and100 mg." @default.
- W2802240813 created "2018-05-17" @default.
- W2802240813 creator A5075374840 @default.
- W2802240813 date "2018-04-16" @default.
- W2802240813 modified "2023-09-24" @default.
- W2802240813 title "Omarigliptin (MARIZEV™, MK-3102)" @default.
- W2802240813 cites W1769745813 @default.
- W2802240813 cites W1851350808 @default.
- W2802240813 cites W1968524774 @default.
- W2802240813 cites W1971265720 @default.
- W2802240813 cites W1974411409 @default.
- W2802240813 cites W1995743501 @default.
- W2802240813 cites W2031195667 @default.
- W2802240813 cites W2031848004 @default.
- W2802240813 cites W2041897619 @default.
- W2802240813 cites W2047353001 @default.
- W2802240813 cites W2058206834 @default.
- W2802240813 cites W2080677146 @default.
- W2802240813 cites W2083473802 @default.
- W2802240813 cites W2085095809 @default.
- W2802240813 cites W2085490648 @default.
- W2802240813 cites W2091122818 @default.
- W2802240813 cites W2107931279 @default.
- W2802240813 cites W2118609667 @default.
- W2802240813 cites W2129563718 @default.
- W2802240813 cites W2149832640 @default.
- W2802240813 cites W2150359377 @default.
- W2802240813 cites W2151185776 @default.
- W2802240813 cites W2159205789 @default.
- W2802240813 cites W2159390850 @default.
- W2802240813 cites W2270722881 @default.
- W2802240813 cites W2769264260 @default.
- W2802240813 cites W610939424 @default.
- W2802240813 doi "https://doi.org/10.1002/9783527808694.ch10" @default.
- W2802240813 hasPublicationYear "2018" @default.
- W2802240813 type Work @default.
- W2802240813 sameAs 2802240813 @default.
- W2802240813 citedByCount "1" @default.
- W2802240813 countsByYear W28022408132020 @default.
- W2802240813 crossrefType "other" @default.
- W2802240813 hasAuthorship W2802240813A5075374840 @default.
- W2802240813 hasConcept C111113717 @default.
- W2802240813 hasConcept C112705442 @default.
- W2802240813 hasConcept C13965031 @default.
- W2802240813 hasConcept C185039092 @default.
- W2802240813 hasConcept C185592680 @default.
- W2802240813 hasConcept C192562407 @default.
- W2802240813 hasConcept C21951064 @default.
- W2802240813 hasConcept C2777288759 @default.
- W2802240813 hasConcept C71240020 @default.
- W2802240813 hasConcept C71924100 @default.
- W2802240813 hasConcept C8010536 @default.
- W2802240813 hasConcept C98274493 @default.
- W2802240813 hasConceptScore W2802240813C111113717 @default.
- W2802240813 hasConceptScore W2802240813C112705442 @default.
- W2802240813 hasConceptScore W2802240813C13965031 @default.
- W2802240813 hasConceptScore W2802240813C185039092 @default.
- W2802240813 hasConceptScore W2802240813C185592680 @default.
- W2802240813 hasConceptScore W2802240813C192562407 @default.
- W2802240813 hasConceptScore W2802240813C21951064 @default.
- W2802240813 hasConceptScore W2802240813C2777288759 @default.
- W2802240813 hasConceptScore W2802240813C71240020 @default.
- W2802240813 hasConceptScore W2802240813C71924100 @default.
- W2802240813 hasConceptScore W2802240813C8010536 @default.
- W2802240813 hasConceptScore W2802240813C98274493 @default.
- W2802240813 hasLocation W28022408131 @default.
- W2802240813 hasOpenAccess W2802240813 @default.
- W2802240813 hasPrimaryLocation W28022408131 @default.
- W2802240813 hasRelatedWork W2004325424 @default.
- W2802240813 hasRelatedWork W2021319218 @default.
- W2802240813 hasRelatedWork W2227061539 @default.
- W2802240813 hasRelatedWork W2245370565 @default.
- W2802240813 hasRelatedWork W2254638634 @default.
- W2802240813 hasRelatedWork W2400384365 @default.
- W2802240813 hasRelatedWork W2594910449 @default.
- W2802240813 hasRelatedWork W2992709639 @default.
- W2802240813 hasRelatedWork W3021369409 @default.
- W2802240813 hasRelatedWork W3174177415 @default.
- W2802240813 isParatext "false" @default.
- W2802240813 isRetracted "false" @default.
- W2802240813 magId "2802240813" @default.
- W2802240813 workType "other" @default.