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- W2802247389 abstract "Diadenosine polyphosphates, Ap(2–7)A, which contain two adenosines in a 5′,5′ linkage through phosphodiester bonds involving 2–7 phosphates, regulate diverse cellular functions in all organisms, from bacteria to humans, under normal and stress conditions. We had earlier reported consistent occurrence of asymmetric constriction during division (ACD) in 20–30% of dividing mycobacterial cells in culture, irrespective of different growth media, implying exogenous action of some factor of mycobacterial origin. Consistent with this premise, concentrated culture supernatant (CCS), but not the equivalent volume-wise concentrated unused medium, dramatically enhanced the ACD proportion to 70–90%. Mass spectrometry and biochemical analyses of the bioactive fraction from CCS revealed the ACD-effecting factor to be Ap6A. Synthetic Ap6A showed a mass spectrometry profile, biochemical characteristics, and bioactivity identical to native Ap6A in the CCS. Thus, the present work reveals a novel role for Ap6A in generating cell-length asymmetry during mycobacterial cell-division and thereby cell-length heterogeneity in the population." @default.
- W2802247389 created "2018-05-17" @default.
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- W2802247389 date "2018-05-14" @default.
- W2802247389 modified "2023-09-24" @default.
- W2802247389 title "A Symmetric Molecule Produced by Mycobacteria Generates Cell-Length Asymmetry during Cell-Division and Thereby Cell-Length Heterogeneity" @default.
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- W2802247389 doi "https://doi.org/10.1021/acschembio.8b00080" @default.
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