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- W2802260464 abstract "INTRODUCTION: Inductions of labor (IOL) vary in their duration and the effects of that variation are largely unknown. This study assesses the impact of IOL duration on neonatal morbidity. METHODS: This retrospective cohort study included all nulliparous women with non-anomalous, singleton, vertex pregnancies who underwent IOL at a tertiary-care academic hospital in 2015. IOL duration was calculated as time from administration of first induction agent to delivery. The primary outcome was neonatal composite morbidity: fetal acidemia, neonatal seizures, hyperbilirubinemia, meconium aspiration with pulmonary hypertension, respiratory distress syndrome, hypoxic ischemic encephalopathy, hypothermic therapy, and/or neonatal readmission. Secondary outcomes were individual components of the composite and neonatal intensive care unit (NICU) admission. We determined the risk of adverse neonatal outcome with increasing length of IOL by logistic regression. RESULTS: Four hundred twenty patients were included. Of these, 59 (14.0%) suffered neonatal morbidity. IOL duration exceeding 36 hours was associated with a statistically significant increased risk of neonatal morbidity (odds ratio [OR] 2.14, 95% confidence interval [CI] 1.2–3.8), which was more prominent after 60 hours (OR 3.2, 95% CI 1.4–7.6). Hyperbilirubinemia was the most common complication (37 cases, 62.7%). Fifty-one neonates (12.1%) were admitted to the NICU. IOL duration exceeding 36 hours was associated with increased risk of NICU admission (OR 2.9, 95% CI 1.6–5.3). CONCLUSION: In nulliparous women undergoing IOL at term, there is an increased risk of adverse neonatal outcome and NICU admission when IOL duration exceeds 36 hours. Further research is needed to determine additional predictors of adverse neonatal outcome in term inductions." @default.
- W2802260464 created "2018-05-17" @default.
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- W2802260464 date "2018-05-01" @default.
- W2802260464 modified "2023-09-25" @default.
- W2802260464 title "Neonatal Morbidity Associated With Duration of Labor Induction [14L]" @default.
- W2802260464 doi "https://doi.org/10.1097/01.aog.0000533553.91562.54" @default.
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