Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802285107> ?p ?o ?g. }
- W2802285107 endingPage "52" @default.
- W2802285107 startingPage "42" @default.
- W2802285107 abstract "The genetic underpinnings that orchestrate the vertebrate heart rate are not fully understood yet, but of high clinical importance, since diseases of cardiac impulse formation and propagation are common and severe human arrhythmias. To identify novel regulators of the vertebrate heart rate, we deciphered the pathogenesis of the bradycardia in the homozygous zebrafish mutant hiphop (hip) and identified a missense-mutation (N851K) in Na+/K+-ATPase α1-subunit (atp1a1a.1). N851K affects zebrafish Na+/K+-ATPase ion transport capacity, as revealed by in vitro pump current measurements. Inhibition of the Na+/K+-ATPase in vivo indicates that hip rather acts as a hypomorph than being a null allele. Consequently, reduced Na+/K+-ATPase function leads to prolonged QT interval and refractoriness in the hip mutant heart, as shown by electrocardiogram and in vivo electrical stimulation experiments. We here demonstrate for the first time that Na+/K+-ATPase plays an essential role in heart rate regulation by prolonging myocardial repolarization." @default.
- W2802285107 created "2018-05-17" @default.
- W2802285107 creator A5001547682 @default.
- W2802285107 creator A5009272032 @default.
- W2802285107 creator A5040531259 @default.
- W2802285107 creator A5045810254 @default.
- W2802285107 creator A5048900524 @default.
- W2802285107 creator A5057642620 @default.
- W2802285107 creator A5062082403 @default.
- W2802285107 creator A5076002023 @default.
- W2802285107 creator A5087017698 @default.
- W2802285107 creator A5088843548 @default.
- W2802285107 date "2018-07-01" @default.
- W2802285107 modified "2023-10-16" @default.
- W2802285107 title "Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish" @default.
- W2802285107 cites W1499088236 @default.
- W2802285107 cites W1508695273 @default.
- W2802285107 cites W1512302512 @default.
- W2802285107 cites W1517941105 @default.
- W2802285107 cites W1939687923 @default.
- W2802285107 cites W1963890550 @default.
- W2802285107 cites W1969379564 @default.
- W2802285107 cites W1974305002 @default.
- W2802285107 cites W1982367466 @default.
- W2802285107 cites W1986671225 @default.
- W2802285107 cites W1992911777 @default.
- W2802285107 cites W1993012529 @default.
- W2802285107 cites W1994683039 @default.
- W2802285107 cites W1999102617 @default.
- W2802285107 cites W2002046677 @default.
- W2802285107 cites W2003131372 @default.
- W2802285107 cites W2008050996 @default.
- W2802285107 cites W2008821347 @default.
- W2802285107 cites W2010687975 @default.
- W2802285107 cites W2011958697 @default.
- W2802285107 cites W2012439821 @default.
- W2802285107 cites W2012665197 @default.
- W2802285107 cites W2013048291 @default.
- W2802285107 cites W2014380310 @default.
- W2802285107 cites W2022422805 @default.
- W2802285107 cites W2022617607 @default.
- W2802285107 cites W2027333162 @default.
- W2802285107 cites W2028638651 @default.
- W2802285107 cites W2032090085 @default.
- W2802285107 cites W2033251924 @default.
- W2802285107 cites W2035694717 @default.
- W2802285107 cites W2039677280 @default.
- W2802285107 cites W2051761500 @default.
- W2802285107 cites W2054527457 @default.
- W2802285107 cites W2058207889 @default.
- W2802285107 cites W2059496396 @default.
- W2802285107 cites W2062779861 @default.
- W2802285107 cites W2063497432 @default.
- W2802285107 cites W2067145688 @default.
- W2802285107 cites W2070857930 @default.
- W2802285107 cites W2074814223 @default.
- W2802285107 cites W2076410926 @default.
- W2802285107 cites W2089238497 @default.
- W2802285107 cites W2090114064 @default.
- W2802285107 cites W2093062385 @default.
- W2802285107 cites W2100965735 @default.
- W2802285107 cites W2101577478 @default.
- W2802285107 cites W2102775181 @default.
- W2802285107 cites W2105460532 @default.
- W2802285107 cites W2108892340 @default.
- W2802285107 cites W2109193104 @default.
- W2802285107 cites W2109625917 @default.
- W2802285107 cites W2110076427 @default.
- W2802285107 cites W2110638394 @default.
- W2802285107 cites W2115571172 @default.
- W2802285107 cites W2120548060 @default.
- W2802285107 cites W2125349610 @default.
- W2802285107 cites W2127216007 @default.
- W2802285107 cites W2128766971 @default.
- W2802285107 cites W2129906353 @default.
- W2802285107 cites W2132595000 @default.
- W2802285107 cites W2135946423 @default.
- W2802285107 cites W2145726938 @default.
- W2802285107 cites W2148335222 @default.
- W2802285107 cites W2153339441 @default.
- W2802285107 cites W2156847869 @default.
- W2802285107 cites W2157022905 @default.
- W2802285107 cites W2168155296 @default.
- W2802285107 cites W2200600461 @default.
- W2802285107 cites W2256802025 @default.
- W2802285107 cites W2296435100 @default.
- W2802285107 cites W2331156693 @default.
- W2802285107 cites W2534241748 @default.
- W2802285107 cites W2557772103 @default.
- W2802285107 cites W2728447508 @default.
- W2802285107 cites W3165208394 @default.
- W2802285107 doi "https://doi.org/10.1016/j.yjmcc.2018.05.005" @default.
- W2802285107 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29750993" @default.
- W2802285107 hasPublicationYear "2018" @default.
- W2802285107 type Work @default.
- W2802285107 sameAs 2802285107 @default.
- W2802285107 citedByCount "16" @default.
- W2802285107 countsByYear W28022851072019 @default.