Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802309094> ?p ?o ?g. }
- W2802309094 endingPage "129" @default.
- W2802309094 startingPage "121" @default.
- W2802309094 abstract "Advanced-stage breast cancer patients comprise a smaller proportion of breast cancer patients than do early stage patients and are more likely to experience a poor outcome. Understanding the underlying molecular mechanisms and identifying new biomarkers for treatment in this subgroup of patients is paramount. With the aim of identifying microRNAs that are regulated in advanced-stage breast cancer, we found lower expression of miR-26b, a member of the miR-26 family, in inflammatory breast cancer and noninflammatory locally advanced breast cancer tissue than in normal breast tissue, by quantitative real-time polymerase chain reaction and in situ hybridization. Quantitative real-time polymerase chain reaction (but not in situ hybridization) also revealed lower miR-26b expression in inflammatory breast cancer than in noninflammatory locally advanced breast cancer. Furthermore, lower expression of miR-26b was correlated with shorter distant metastasis–free survival and overall survival in univariate analysis, and with shorter overall survival in multivariate analysis. The expression of miRNA-26b was inversely associated with EZH2 protein expression in several breast cancer cell lines, and overexpression and knockdown of miR-26b caused corresponding changes in EZH2 expression. Our study shows that miR-26b may regulate EZH2 expression in breast cancer and may be useful as a therapeutic target for inflammatory breast cancer and noninflammatory locally advanced breast cancer." @default.
- W2802309094 created "2018-05-17" @default.
- W2802309094 creator A5000514150 @default.
- W2802309094 creator A5001315712 @default.
- W2802309094 creator A5002278126 @default.
- W2802309094 creator A5003107322 @default.
- W2802309094 creator A5003799076 @default.
- W2802309094 creator A5013934813 @default.
- W2802309094 creator A5022495524 @default.
- W2802309094 creator A5027464426 @default.
- W2802309094 creator A5032987754 @default.
- W2802309094 creator A5035895874 @default.
- W2802309094 creator A5045166646 @default.
- W2802309094 creator A5051758545 @default.
- W2802309094 creator A5052297489 @default.
- W2802309094 creator A5065666529 @default.
- W2802309094 creator A5069309658 @default.
- W2802309094 creator A5070170359 @default.
- W2802309094 creator A5072661022 @default.
- W2802309094 creator A5077756892 @default.
- W2802309094 creator A5078676025 @default.
- W2802309094 creator A5084597185 @default.
- W2802309094 creator A5084940588 @default.
- W2802309094 creator A5088293773 @default.
- W2802309094 creator A5088814426 @default.
- W2802309094 creator A5089771018 @default.
- W2802309094 date "2018-07-01" @default.
- W2802309094 modified "2023-09-27" @default.
- W2802309094 title "Decreased expression of microRNA-26b in locally advanced and inflammatory breast cancer" @default.
- W2802309094 cites W144423133 @default.
- W2802309094 cites W1514059715 @default.
- W2802309094 cites W1965427258 @default.
- W2802309094 cites W1976585056 @default.
- W2802309094 cites W1996348049 @default.
- W2802309094 cites W1996963134 @default.
- W2802309094 cites W2004380688 @default.
- W2802309094 cites W2011670486 @default.
- W2802309094 cites W2032923154 @default.
- W2802309094 cites W2040349368 @default.
- W2802309094 cites W2042857642 @default.
- W2802309094 cites W2050850788 @default.
- W2802309094 cites W2052609775 @default.
- W2802309094 cites W2059058989 @default.
- W2802309094 cites W2070578980 @default.
- W2802309094 cites W2073599009 @default.
- W2802309094 cites W2081119041 @default.
- W2802309094 cites W2083255319 @default.
- W2802309094 cites W2087685591 @default.
- W2802309094 cites W2100543217 @default.
- W2802309094 cites W2105613536 @default.
- W2802309094 cites W2113334910 @default.
- W2802309094 cites W2131431946 @default.
- W2802309094 cites W2135836598 @default.
- W2802309094 cites W2136382192 @default.
- W2802309094 cites W2148276874 @default.
- W2802309094 cites W2150536104 @default.
- W2802309094 cites W2150728173 @default.
- W2802309094 cites W2153893502 @default.
- W2802309094 cites W2154729913 @default.
- W2802309094 cites W2159807040 @default.
- W2802309094 cites W2160102037 @default.
- W2802309094 cites W2161899462 @default.
- W2802309094 cites W2163229196 @default.
- W2802309094 cites W2165708610 @default.
- W2802309094 cites W2224767631 @default.
- W2802309094 cites W2235523093 @default.
- W2802309094 cites W2264682687 @default.
- W2802309094 cites W2265951579 @default.
- W2802309094 cites W2286126342 @default.
- W2802309094 cites W2288763477 @default.
- W2802309094 cites W2300543067 @default.
- W2802309094 cites W2320064657 @default.
- W2802309094 cites W2328788814 @default.
- W2802309094 cites W2428564903 @default.
- W2802309094 cites W2491251888 @default.
- W2802309094 cites W2509824916 @default.
- W2802309094 cites W2529260763 @default.
- W2802309094 cites W2564122157 @default.
- W2802309094 cites W2581461502 @default.
- W2802309094 cites W2587259936 @default.
- W2802309094 cites W2610210333 @default.
- W2802309094 cites W2675535495 @default.
- W2802309094 cites W2735024329 @default.
- W2802309094 cites W2739338088 @default.
- W2802309094 cites W4231018668 @default.
- W2802309094 doi "https://doi.org/10.1016/j.humpath.2018.04.002" @default.
- W2802309094 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29689244" @default.
- W2802309094 hasPublicationYear "2018" @default.
- W2802309094 type Work @default.
- W2802309094 sameAs 2802309094 @default.
- W2802309094 citedByCount "21" @default.
- W2802309094 countsByYear W28023090942018 @default.
- W2802309094 countsByYear W28023090942019 @default.
- W2802309094 countsByYear W28023090942020 @default.
- W2802309094 countsByYear W28023090942021 @default.
- W2802309094 countsByYear W28023090942022 @default.
- W2802309094 countsByYear W28023090942023 @default.
- W2802309094 crossrefType "journal-article" @default.