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• W2802334013 abstract "To meet the long-standing challenge of a one-step, last-stage aqueous radiofluorination method for labeling large, water-soluble molecules such as peptides, we sought a mild aqueous fluorination reaction that uses organoboron compositions, which are readily fluorinated in mild aqueous acid to give 18F-labeled organotrifluoroborates. This robust reaction now provides new 18F-labeled radioprosthetic groups that can be pre-conjugated to peptides and other polar molecules, and then labeled with aqueous no-carrier-added (NCA) [18F]fluoride ion in a single step. A key application facilitated by this method is the production of 18F-labeled fluorescent-PET tracers. The development of these radioprosthetics, their elaboration onto peptides, and their extension to fluorescent bioconjugates is the focus of this review." @default.
• W2802334013 created "2018-05-17" @default.
• W2802334013 creator A5004769994 @default.
• W2802334013 date "2018-08-01" @default.
• W2802334013 modified "2023-10-09" @default.
• W2802334013 title "Organotrifluoroborates as prosthetic groups for Single-Step F18-Labeling of Complex Molecules" @default.
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• W2802334013 doi "https://doi.org/10.1016/j.cbpa.2018.03.001" @default.
• W2802334013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29684871" @default.
• W2802334013 hasPublicationYear "2018" @default.
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