FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802382956> ?p ?o ?g. }

• W2802382956 abstract "Endometriosis is a complex and heterogeneous pre‑malignant inflammatory disease harboring multiple gene mutations. Previous studies have suggested that caspase recruitment domain family member (CARD)10 and CARD11 mutations may exist in endometriosis. In the present study, a collection of endometriotic lesions and paired peripheral blood from 101 patients with ovarian endometriosis were obtained, and the entire coding sequences of the CARD10 and CARD11 genes were sequenced. Evolutionary conservation analysis and online prediction programs were applied to analyze the disease‑causing potential of the identified mutations. A total of 4 novel somatic mutations were identified in 4 out of the 101 (4.0%) samples: 2 in‑frame deletions in CARD10 (c.785_790delAGGAGA, p.K272_E273delKE; c.785_802delAGGAGAAGGAGAAGGAGA, p.K272_V277delKEPDNV) and 2 heterozygous missense mutations in CARD11 (c.49G>T, p.D17Y; c.160G>C, p.E54Q). The sample with CARD10 p.K272_E273delKE deletion was obtained from a 47‑year‑old patient who was also diagnosed with uterine leiomyoma, while the CARD10 p.K272_V277delKEPDNV‑mutated sample was from a 43‑year‑old patient exhibiting a decreased blood eosinophil granulocyte ratio (0.3%) and an elevated serum creatine kinase level (314 U/l). The patient with the CARD11 p.D17Y mutation was 38 years old and exhibited an increased level of cancer antigen 125 (45.4 U/ml), while the patient with the CARD11 p.E54Q mutation was 46 years old and exhibited no other gynecological conditions. Evolutionary conservation analysis and online prediction programs suggested that these mutations may be disease‑causing. In summary, 4 novel somatic mutations in the CARD10 and CARD11 genes were identified from amongst 101 cases of ovarian endometriosis for the first time, these mutations may serve active roles in the development of ovarian endometriosis." @default.
• W2802382956 created "2018-05-17" @default.
• W2802382956 creator A5003758757 @default.
• W2802382956 creator A5008010030 @default.
• W2802382956 creator A5020307714 @default.
• W2802382956 creator A5022770789 @default.
• W2802382956 creator A5025088956 @default.
• W2802382956 creator A5030495270 @default.
• W2802382956 creator A5047605259 @default.
• W2802382956 creator A5059412519 @default.
• W2802382956 creator A5065969815 @default.
• W2802382956 creator A5076587134 @default.
• W2802382956 date "2018-05-08" @default.
• W2802382956 modified "2023-10-14" @default.
• W2802382956 title "Analysis of CARD10 and CARD11 somatic mutations in patients with ovarian endometriosis" @default.
• W2802382956 cites W1520611110 @default.
• W2802382956 cites W1560626543 @default.
• W2802382956 cites W1845098007 @default.
• W2802382956 cites W1966049599 @default.
• W2802382956 cites W1970413157 @default.
• W2802382956 cites W1979816280 @default.
• W2802382956 cites W1980383179 @default.
• W2802382956 cites W1980740976 @default.
• W2802382956 cites W1980790363 @default.
• W2802382956 cites W1998296936 @default.
• W2802382956 cites W2014293477 @default.
• W2802382956 cites W2030686715 @default.
• W2802382956 cites W2031855605 @default.
• W2802382956 cites W2039733169 @default.
• W2802382956 cites W2059145105 @default.
• W2802382956 cites W2059685005 @default.
• W2802382956 cites W2079886421 @default.
• W2802382956 cites W2083418262 @default.
• W2802382956 cites W2090330334 @default.
• W2802382956 cites W2097198003 @default.
• W2802382956 cites W2097501793 @default.
• W2802382956 cites W2102586246 @default.
• W2802382956 cites W2110474031 @default.
• W2802382956 cites W2126817554 @default.
• W2802382956 cites W2129793603 @default.
• W2802382956 cites W2143430056 @default.
• W2802382956 cites W2154312575 @default.
• W2802382956 cites W2159228424 @default.
• W2802382956 cites W2161877815 @default.
• W2802382956 cites W2164241627 @default.
• W2802382956 cites W2169528901 @default.
• W2802382956 cites W2174515690 @default.
• W2802382956 cites W2176200814 @default.
• W2802382956 cites W2215928263 @default.
• W2802382956 cites W2263646411 @default.
• W2802382956 cites W2263993110 @default.
• W2802382956 cites W2286138571 @default.
• W2802382956 cites W2299761529 @default.
• W2802382956 cites W2311203695 @default.
• W2802382956 cites W2340936662 @default.
• W2802382956 cites W2508142804 @default.
• W2802382956 cites W2535072167 @default.
• W2802382956 cites W2612851374 @default.
• W2802382956 cites W4248793083 @default.
• W2802382956 doi "https://doi.org/10.3892/ol.2018.8659" @default.
• W2802382956 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6006461" @default.
• W2802382956 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29928437" @default.
• W2802382956 hasPublicationYear "2018" @default.
• W2802382956 type Work @default.
• W2802382956 sameAs 2802382956 @default.
• W2802382956 citedByCount "6" @default.
• W2802382956 countsByYear W28023829562019 @default.
• W2802382956 countsByYear W28023829562021 @default.
• W2802382956 countsByYear W28023829562022 @default.
• W2802382956 countsByYear W28023829562023 @default.
• W2802382956 crossrefType "journal-article" @default.
• W2802382956 hasAuthorship W2802382956A5003758757 @default.
• W2802382956 hasAuthorship W2802382956A5008010030 @default.
• W2802382956 hasAuthorship W2802382956A5020307714 @default.
• W2802382956 hasAuthorship W2802382956A5022770789 @default.
• W2802382956 hasAuthorship W2802382956A5025088956 @default.
• W2802382956 hasAuthorship W2802382956A5030495270 @default.
• W2802382956 hasAuthorship W2802382956A5047605259 @default.
• W2802382956 hasAuthorship W2802382956A5059412519 @default.
• W2802382956 hasAuthorship W2802382956A5065969815 @default.
• W2802382956 hasAuthorship W2802382956A5076587134 @default.
• W2802382956 hasBestOaLocation W28023829561 @default.
• W2802382956 hasConcept C104317684 @default.
• W2802382956 hasConcept C121608353 @default.
• W2802382956 hasConcept C134305767 @default.
• W2802382956 hasConcept C13514818 @default.
• W2802382956 hasConcept C142724271 @default.
• W2802382956 hasConcept C2777088508 @default.
• W2802382956 hasConcept C2779522080 @default.
• W2802382956 hasConcept C2780427987 @default.
• W2802382956 hasConcept C501734568 @default.
• W2802382956 hasConcept C502942594 @default.
• W2802382956 hasConcept C54355233 @default.
• W2802382956 hasConcept C71924100 @default.
• W2802382956 hasConcept C75563809 @default.
• W2802382956 hasConcept C86803240 @default.
• W2802382956 hasConceptScore W2802382956C104317684 @default.
• W2802382956 hasConceptScore W2802382956C121608353 @default.
• W2802382956 hasConceptScore W2802382956C134305767 @default.
• W2802382956 hasConceptScore W2802382956C13514818 @default.

• next