Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802393746> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2802393746 abstract "Morphogenesis - the generation of biological shape and form - is fascinating, and its study promises to shed light on a wide range of developmental defects and inform strategies for the artificial growth of organs. Recently, the experimental study of morphogenesis has thrived due to a rise in quantitative methods.The resulting avalanche of quantitative data requires us to rethink the scientific method. We need to design quantitative hypotheses through mathematical models, make quantitative experimental predictions, devise methods for quantitative data analysis, and design methods for quantitative inference using models and data. This thesis aims to enable this transition for the integrative analysis of morphogenesis in epithelia, one of the major tissue types in animals. We begin by conducting the first systematic numerical analysis of a widely used cell-based model of epithelia, the vertex model, and estimate to what extent quantitative model predictions may be influenced by parameter values and implementation details. We then apply this model to a key question in developmental biology by constructing a quantitative theory for tissue size control in the embryonic epidermis of the fruit fly Drosophila, using the model to predict the outcomes of future experiments. Subsequently, we devise a method for estimating mechanical parameters of vertex models from imaging data and quantifying the uncertainty associated with such estimates. Finally, we propose a novel algorithm for robust cell tracking in live-imaging microscopy videos of epithelial tissues that illustrates how graph theoretic concepts may be used to overcome challenges in quantitative data analysis. Together, the contributions in this thesis will enable the quantitative study of epithelia for a wide range of applications." @default.
- W2802393746 created "2018-05-17" @default.
- W2802393746 creator A5026379620 @default.
- W2802393746 date "2018-01-01" @default.
- W2802393746 modified "2023-09-26" @default.
- W2802393746 title "Quantitative approaches to investigating epithelial morphogenesis" @default.
- W2802393746 hasPublicationYear "2018" @default.
- W2802393746 type Work @default.
- W2802393746 sameAs 2802393746 @default.
- W2802393746 citedByCount "0" @default.
- W2802393746 crossrefType "dissertation" @default.
- W2802393746 hasAuthorship W2802393746A5026379620 @default.
- W2802393746 hasConcept C104317684 @default.
- W2802393746 hasConcept C105795698 @default.
- W2802393746 hasConcept C144024400 @default.
- W2802393746 hasConcept C154945302 @default.
- W2802393746 hasConcept C185592680 @default.
- W2802393746 hasConcept C186060115 @default.
- W2802393746 hasConcept C19165224 @default.
- W2802393746 hasConcept C2776214188 @default.
- W2802393746 hasConcept C2984588014 @default.
- W2802393746 hasConcept C33923547 @default.
- W2802393746 hasConcept C40692019 @default.
- W2802393746 hasConcept C41008148 @default.
- W2802393746 hasConcept C43617362 @default.
- W2802393746 hasConcept C55037315 @default.
- W2802393746 hasConcept C55493867 @default.
- W2802393746 hasConcept C86803240 @default.
- W2802393746 hasConcept C87858587 @default.
- W2802393746 hasConcept C95986675 @default.
- W2802393746 hasConceptScore W2802393746C104317684 @default.
- W2802393746 hasConceptScore W2802393746C105795698 @default.
- W2802393746 hasConceptScore W2802393746C144024400 @default.
- W2802393746 hasConceptScore W2802393746C154945302 @default.
- W2802393746 hasConceptScore W2802393746C185592680 @default.
- W2802393746 hasConceptScore W2802393746C186060115 @default.
- W2802393746 hasConceptScore W2802393746C19165224 @default.
- W2802393746 hasConceptScore W2802393746C2776214188 @default.
- W2802393746 hasConceptScore W2802393746C2984588014 @default.
- W2802393746 hasConceptScore W2802393746C33923547 @default.
- W2802393746 hasConceptScore W2802393746C40692019 @default.
- W2802393746 hasConceptScore W2802393746C41008148 @default.
- W2802393746 hasConceptScore W2802393746C43617362 @default.
- W2802393746 hasConceptScore W2802393746C55037315 @default.
- W2802393746 hasConceptScore W2802393746C55493867 @default.
- W2802393746 hasConceptScore W2802393746C86803240 @default.
- W2802393746 hasConceptScore W2802393746C87858587 @default.
- W2802393746 hasConceptScore W2802393746C95986675 @default.
- W2802393746 hasLocation W28023937461 @default.
- W2802393746 hasOpenAccess W2802393746 @default.
- W2802393746 hasPrimaryLocation W28023937461 @default.
- W2802393746 hasRelatedWork W2021997543 @default.
- W2802393746 hasRelatedWork W2102434872 @default.
- W2802393746 hasRelatedWork W2165285607 @default.
- W2802393746 hasRelatedWork W2224362007 @default.
- W2802393746 hasRelatedWork W2503839997 @default.
- W2802393746 hasRelatedWork W2739144044 @default.
- W2802393746 hasRelatedWork W2741442888 @default.
- W2802393746 hasRelatedWork W2792924400 @default.
- W2802393746 hasRelatedWork W2793570956 @default.
- W2802393746 hasRelatedWork W2890311405 @default.
- W2802393746 hasRelatedWork W2949890765 @default.
- W2802393746 hasRelatedWork W2950122445 @default.
- W2802393746 hasRelatedWork W2950220557 @default.
- W2802393746 hasRelatedWork W2963502018 @default.
- W2802393746 hasRelatedWork W2990230625 @default.
- W2802393746 hasRelatedWork W3080214766 @default.
- W2802393746 hasRelatedWork W3082002174 @default.
- W2802393746 hasRelatedWork W3101798503 @default.
- W2802393746 hasRelatedWork W2185820881 @default.
- W2802393746 hasRelatedWork W3024379478 @default.
- W2802393746 isParatext "false" @default.
- W2802393746 isRetracted "false" @default.
- W2802393746 magId "2802393746" @default.
- W2802393746 workType "dissertation" @default.