FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802396543> ?p ?o ?g. }

• W2802396543 endingPage "841" @default.
• W2802396543 startingPage "831" @default.
• W2802396543 abstract "Docetaxel chemotherapy is a standard of care for metastatic castrate-resistant prostate cancer (mCRPC): 40-50% of patients achieve a biochemical response. However, there is a lack of response predictive biomarkers.To assess lactate dehydrogenase (LDH) as a docetaxel response biomarker in mCRPC and to examine the association of LDH with genomic alterations in primary diagnostic biopsies.Clinical and associated primary tumour-targeted next-generation sequencing data from matched training (n=150) and test (n=120) cohorts of progressive mCRPC patients receiving docetaxel therapy were analysed. Data were correlated with large-scale prostate cancer genomic datasets.Prostate-specific antigen (PSA) response, radiographic response, biochemical progression-free survival (PFS), overall survival (OS), genomic analysis of primary biopsies, and genomic datasets (Memorial Sloan Kettering Cancer Center [MSKCC] and SU2C/PCF).Serum LDH ≥450U/l is a reliable prognostic biomarker (area under the curve: 0.757 [standard deviation 0.054, 95% confidence interval [CI] 0.650-0.864, p<0.001]) in progressive mCRPC, predicting PFS at 3 mo. Patients with LDH ≥450U/l were poorer PSA responders, with shorter PFS (213 vs 372 d, hazard ratio [HR] 1.876, 95% CI 1.289-2.7300) and OS (362 vs 563 d, HR 1.630, 95% CI 1.127-2.357). High LDH is an independent surrogate marker for survival following docetaxel and predicts a poor radiological response (p=0.043). Of the 14 patients with LDH ≥450U/l available for next-generation sequencing, nine (64.3%) were more likely to have DNA repair gene mutation(s) (BRCA1/2, ATM, CHEK2, Fanconi anaemia gene) in their primary biopsy. Cross correlation with MSKCC and SU2C/PCF databases revealed a positive correlation between LDHA, PARP1 (r=0.667, p<0.01), and other DNA repair genes.Genomic abnormalities of LDHA and DNA repair in primary biopsies link to high pretreatment LDH and poor response to docetaxel in mCRPC.The presence of mutations of the lactate dehydrogenase and DNA repair pathways are associated with aggressive prostate cancer and poor response to chemotherapy later in the disease." @default.
• W2802396543 created "2018-05-17" @default.
• W2802396543 creator A5007895871 @default.
• W2802396543 creator A5029127354 @default.
• W2802396543 creator A5035160400 @default.
• W2802396543 creator A5043115964 @default.
• W2802396543 creator A5043741473 @default.
• W2802396543 creator A5058318196 @default.
• W2802396543 creator A5065195021 @default.
• W2802396543 creator A5076098983 @default.
• W2802396543 creator A5089777135 @default.
• W2802396543 creator A5091666679 @default.
• W2802396543 date "2019-09-01" @default.
• W2802396543 modified "2023-10-03" @default.
• W2802396543 title "Primary Mutational Landscape Linked with Pre-Docetaxel Lactate Dehydrogenase Levels Predicts Docetaxel Response in Metastatic Castrate-Resistant Prostate Cancer" @default.
• W2802396543 cites W1578291413 @default.
• W2802396543 cites W1990949011 @default.
• W2802396543 cites W2023098134 @default.
• W2802396543 cites W2046001919 @default.
• W2802396543 cites W2051025382 @default.
• W2802396543 cites W2055229817 @default.
• W2802396543 cites W2060364342 @default.
• W2802396543 cites W2080439368 @default.
• W2802396543 cites W2083144753 @default.
• W2802396543 cites W2102322990 @default.
• W2802396543 cites W2103090668 @default.
• W2802396543 cites W2107633226 @default.
• W2802396543 cites W2120292596 @default.
• W2802396543 cites W2129128353 @default.
• W2802396543 cites W2130875528 @default.
• W2802396543 cites W2132166432 @default.
• W2802396543 cites W2135925159 @default.
• W2802396543 cites W2149441684 @default.
• W2802396543 cites W2160981405 @default.
• W2802396543 cites W2161112598 @default.
• W2802396543 cites W2235405584 @default.
• W2802396543 cites W2552908002 @default.
• W2802396543 cites W2606495925 @default.
• W2802396543 doi "https://doi.org/10.1016/j.euf.2018.04.006" @default.
• W2802396543 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29699892" @default.
• W2802396543 hasPublicationYear "2019" @default.
• W2802396543 type Work @default.
• W2802396543 sameAs 2802396543 @default.
• W2802396543 citedByCount "9" @default.
• W2802396543 countsByYear W28023965432019 @default.
• W2802396543 countsByYear W28023965432020 @default.
• W2802396543 countsByYear W28023965432021 @default.
• W2802396543 crossrefType "journal-article" @default.
• W2802396543 hasAuthorship W2802396543A5007895871 @default.
• W2802396543 hasAuthorship W2802396543A5029127354 @default.
• W2802396543 hasAuthorship W2802396543A5035160400 @default.
• W2802396543 hasAuthorship W2802396543A5043115964 @default.
• W2802396543 hasAuthorship W2802396543A5043741473 @default.
• W2802396543 hasAuthorship W2802396543A5058318196 @default.
• W2802396543 hasAuthorship W2802396543A5065195021 @default.
• W2802396543 hasAuthorship W2802396543A5076098983 @default.
• W2802396543 hasAuthorship W2802396543A5089777135 @default.
• W2802396543 hasAuthorship W2802396543A5091666679 @default.
• W2802396543 hasBestOaLocation W28023965431 @default.
• W2802396543 hasConcept C121608353 @default.
• W2802396543 hasConcept C126322002 @default.
• W2802396543 hasConcept C143998085 @default.
• W2802396543 hasConcept C181199279 @default.
• W2802396543 hasConcept C207103383 @default.
• W2802396543 hasConcept C2777318727 @default.
• W2802396543 hasConcept C2780192828 @default.
• W2802396543 hasConcept C2781190966 @default.
• W2802396543 hasConcept C2781197716 @default.
• W2802396543 hasConcept C44249647 @default.
• W2802396543 hasConcept C55493867 @default.
• W2802396543 hasConcept C71924100 @default.
• W2802396543 hasConcept C86803240 @default.
• W2802396543 hasConceptScore W2802396543C121608353 @default.
• W2802396543 hasConceptScore W2802396543C126322002 @default.
• W2802396543 hasConceptScore W2802396543C143998085 @default.
• W2802396543 hasConceptScore W2802396543C181199279 @default.
• W2802396543 hasConceptScore W2802396543C207103383 @default.
• W2802396543 hasConceptScore W2802396543C2777318727 @default.
• W2802396543 hasConceptScore W2802396543C2780192828 @default.
• W2802396543 hasConceptScore W2802396543C2781190966 @default.
• W2802396543 hasConceptScore W2802396543C2781197716 @default.
• W2802396543 hasConceptScore W2802396543C44249647 @default.
• W2802396543 hasConceptScore W2802396543C55493867 @default.
• W2802396543 hasConceptScore W2802396543C71924100 @default.
• W2802396543 hasConceptScore W2802396543C86803240 @default.
• W2802396543 hasIssue "5" @default.
• W2802396543 hasLocation W28023965431 @default.
• W2802396543 hasLocation W28023965432 @default.
• W2802396543 hasLocation W28023965433 @default.
• W2802396543 hasOpenAccess W2802396543 @default.
• W2802396543 hasPrimaryLocation W28023965431 @default.
• W2802396543 hasRelatedWork W1898921923 @default.
• W2802396543 hasRelatedWork W2010765098 @default.
• W2802396543 hasRelatedWork W2060708716 @default.
• W2802396543 hasRelatedWork W2094570582 @default.
• W2802396543 hasRelatedWork W2588988563 @default.
• W2802396543 hasRelatedWork W2735900144 @default.
• W2802396543 hasRelatedWork W2770702948 @default.

• next