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- W2802397310 endingPage "1166" @default.
- W2802397310 startingPage "1166" @default.
- W2802397310 abstract "Advances in technology have facilitated the molecular profiling (genomic and transcriptomic) of tumours, and has led to improved stratification of patients and the individualisation of treatment regimes. To fully realize the potential of truly personalised treatment options, we need targeted therapies that precisely disrupt the compensatory pathways identified by profiling which allow tumours to survive or gain resistance to treatments. Here, we discuss recent advances in novel therapies that impact the genome (chromosomes and chromatin), pathways targeted and the stage of the pathways targeted. The current state of research will be discussed, with a focus on compounds that have advanced into trials (clinical and pre-clinical). We will discuss inhibitors of specific DNA damage responses and other genome stability pathways, including those in development, which are likely to synergistically combine with current therapeutic options. Tumour profiling data, combined with the knowledge of new treatments that affect the regulation of essential tumour signalling pathways, is revealing fundamental insights into cancer progression and resistance mechanisms. This is the forefront of the next evolution of advanced oncology medicine that will ultimately lead to improved survival and may, one day, result in many cancers becoming chronic conditions, rather than fatal diseases." @default.
- W2802397310 created "2018-05-17" @default.
- W2802397310 creator A5019091122 @default.
- W2802397310 creator A5032001088 @default.
- W2802397310 creator A5043304411 @default.
- W2802397310 creator A5077299318 @default.
- W2802397310 date "2018-05-13" @default.
- W2802397310 modified "2023-10-03" @default.
- W2802397310 title "Clinically Applicable Inhibitors Impacting Genome Stability" @default.
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