Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802397669> ?p ?o ?g. }
- W2802397669 endingPage "285101" @default.
- W2802397669 startingPage "285101" @default.
- W2802397669 abstract "The topical treatment for oral mucosal diseases is often based on products optimized for dermatologic applications; consequently, a lower therapeutic effect may be present. 18-β-glycyrrhetic acid (GA) is extracted from Glycirrhiza glabra. The first aim of this study was to test the cytotoxicity of GA on PE/CA-PJ15 cells. The second aim was to propose and test two different delivery systems, i.e. nanoparticles and fibers, to guarantee a controlled release of GA in vitro. We used chitosan and poly(lactic-co-glycolic) acid based nanoparticles and polylactic acid fibers. We tested both delivery systems in vitro on PE/CA-PJ15 cells and on normal human gingival fibroblasts (HGFs). The morphology of GA-loaded nanoparticles (GA-NPs) and fibers (GA-FBs) was investigated by electron microscopy and dynamic light scattering; GA release kinetics was studied spectrophotometrically. MTT test was used to assess GA cytotoxicity on both cancer and normal cells. Cells were exposed to different concentrations of GA (20-500 μmol l-1) administered as free GA (GA-f), and to GA-NPs or GA-FBs. ROS production was evaluated using dichlorodihydrofluorescein as a fluorescent probe. Regarding the cytotoxic effect of GA on PE/CA-PJ15 cells, the lowest TC50 value was 200 μmol l-1 when GA was added as GA-NPs. No cytotoxic effects were observed when GA was administered to HGFs. N-acetyl Cysteine reduced mortality induced by GA-f in PE/CA-PJ15 cells. The specific effect of GA on PE/CA-PJ15 cells is mainly due to the different sensitivity of cancer cells to ROS over-production; GA-NPs and GA-FBs formulations increase, in vitro, this toxic effect on oral cancer cells." @default.
- W2802397669 created "2018-05-17" @default.
- W2802397669 creator A5003607573 @default.
- W2802397669 creator A5009763206 @default.
- W2802397669 creator A5012108322 @default.
- W2802397669 creator A5019271461 @default.
- W2802397669 creator A5021318728 @default.
- W2802397669 creator A5022904462 @default.
- W2802397669 creator A5028742530 @default.
- W2802397669 creator A5043661076 @default.
- W2802397669 creator A5054010218 @default.
- W2802397669 creator A5057831201 @default.
- W2802397669 creator A5070921491 @default.
- W2802397669 creator A5085091120 @default.
- W2802397669 creator A5087600197 @default.
- W2802397669 creator A5091047299 @default.
- W2802397669 date "2018-05-11" @default.
- W2802397669 modified "2023-10-03" @default.
- W2802397669 title "Controlled release of 18-<i>β</i>-glycyrrhetic acid by nanodelivery systems increases cytotoxicity on oral carcinoma cell line" @default.
- W2802397669 cites W142608720 @default.
- W2802397669 cites W1486369761 @default.
- W2802397669 cites W1498619883 @default.
- W2802397669 cites W1571301936 @default.
- W2802397669 cites W1630865570 @default.
- W2802397669 cites W1830623697 @default.
- W2802397669 cites W1870111729 @default.
- W2802397669 cites W1971187465 @default.
- W2802397669 cites W1982088633 @default.
- W2802397669 cites W1984156263 @default.
- W2802397669 cites W1996863779 @default.
- W2802397669 cites W1996933787 @default.
- W2802397669 cites W2000718634 @default.
- W2802397669 cites W2001584318 @default.
- W2802397669 cites W2004848067 @default.
- W2802397669 cites W2005375909 @default.
- W2802397669 cites W2005645906 @default.
- W2802397669 cites W2007158142 @default.
- W2802397669 cites W2010722285 @default.
- W2802397669 cites W2012184744 @default.
- W2802397669 cites W2019156998 @default.
- W2802397669 cites W2019473659 @default.
- W2802397669 cites W2022758456 @default.
- W2802397669 cites W2023790872 @default.
- W2802397669 cites W2024011356 @default.
- W2802397669 cites W2031554637 @default.
- W2802397669 cites W2034225403 @default.
- W2802397669 cites W2037376387 @default.
- W2802397669 cites W2039142173 @default.
- W2802397669 cites W2043121769 @default.
- W2802397669 cites W2044083635 @default.
- W2802397669 cites W2045721400 @default.
- W2802397669 cites W2048420511 @default.
- W2802397669 cites W2051623135 @default.
- W2802397669 cites W2052196877 @default.
- W2802397669 cites W2055520654 @default.
- W2802397669 cites W2060385134 @default.
- W2802397669 cites W2063445457 @default.
- W2802397669 cites W2064357763 @default.
- W2802397669 cites W2064821104 @default.
- W2802397669 cites W2066078622 @default.
- W2802397669 cites W2068053528 @default.
- W2802397669 cites W2070849710 @default.
- W2802397669 cites W2084146115 @default.
- W2802397669 cites W2087032263 @default.
- W2802397669 cites W2088301727 @default.
- W2802397669 cites W2089347741 @default.
- W2802397669 cites W2092308579 @default.
- W2802397669 cites W2098092331 @default.
- W2802397669 cites W2104468790 @default.
- W2802397669 cites W2128271989 @default.
- W2802397669 cites W2143190453 @default.
- W2802397669 cites W2144144743 @default.
- W2802397669 cites W2153678988 @default.
- W2802397669 cites W2163088859 @default.
- W2802397669 cites W2169266471 @default.
- W2802397669 cites W2170958988 @default.
- W2802397669 cites W2175375867 @default.
- W2802397669 cites W2211664220 @default.
- W2802397669 cites W2238243157 @default.
- W2802397669 cites W2241227789 @default.
- W2802397669 cites W2305615658 @default.
- W2802397669 cites W2306855163 @default.
- W2802397669 cites W2508070837 @default.
- W2802397669 cites W2566245995 @default.
- W2802397669 cites W2594072584 @default.
- W2802397669 cites W2594205674 @default.
- W2802397669 cites W2623389918 @default.
- W2802397669 cites W2120417201 @default.
- W2802397669 doi "https://doi.org/10.1088/1361-6528/aabecc" @default.
- W2802397669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29664420" @default.
- W2802397669 hasPublicationYear "2018" @default.
- W2802397669 type Work @default.
- W2802397669 sameAs 2802397669 @default.
- W2802397669 citedByCount "35" @default.
- W2802397669 countsByYear W28023976692018 @default.
- W2802397669 countsByYear W28023976692019 @default.
- W2802397669 countsByYear W28023976692020 @default.
- W2802397669 countsByYear W28023976692021 @default.