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• W2802398839 abstract "Butyrate (BT) is a ubiquitous short-chain fatty acid (SCFA) principally derived from the enteric microbiome. BT positively modulates mitochondrial function, including enhancing oxidative phosphorylation and beta-oxidation and has been proposed as a neuroprotectant. BT and other SCFAs have also been associated with autism spectrum disorders (ASD), a condition associated with mitochondrial dysfunction. We have developed a lymphoblastoid cell line (LCL) model of ASD, with a subset of LCLs demonstrating mitochondrial dysfunction (AD-A) and another subset of LCLs demonstrating normal mitochondrial function (AD-N). Given the positive modulation of BT on mitochondrial function, we hypothesized that BT would have a preferential positive effect on AD-A LCLs. To this end, we measured mitochondrial function in ASD and age-matched control (CNT) LCLs, all derived from boys, following 24 and 48 h exposure to BT (0, 0.1, 0.5, and 1 mM) both with and without an in vitro increase in reactive oxygen species (ROS). We also examined the expression of key genes involved in cellular and mitochondrial response to stress. In CNT LCLs, respiratory parameters linked to adenosine triphosphate (ATP) production were attenuated by 1 mM BT. In contrast, BT significantly increased respiratory parameters linked to ATP production in AD-A LCLs but not in AD-N LCLs. In the context of ROS exposure, BT increased respiratory parameters linked to ATP production for all groups. BT was found to modulate individual LCL mitochondrial respiration to a common set-point, with this set-point slightly higher for the AD-A LCLs as compared to the other groups. The highest concentration of BT (1 mM) increased the expression of genes involved in mitochondrial fission (PINK1, DRP1, FIS1) and physiological stress (UCP2, mTOR, HIF1α, PGC1α) as well as genes thought to be linked to cognition and behavior (CREB1, CamKinase II). These data show that the enteric microbiome-derived SCFA BT modulates mitochondrial activity, with this modulation dependent on concentration, microenvironment redox state, and the underlying mitochondrial function of the cell. In general, these data suggest that BT can enhance mitochondrial function in the context of physiological stress and/or mitochondrial dysfunction, and may be an important metabolite that can help rescue energy metabolism during disease states. Thus, insight into this metabolic modulator may have wide applications for both health and disease since BT has been implicated in a wide variety of conditions including ASD. However, future clinical studies in humans are needed to help define the practical implications of these physiological findings." @default.
• W2802398839 created "2018-05-17" @default.
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• W2802398839 date "2018-02-02" @default.
• W2802398839 modified "2023-10-15" @default.
• W2802398839 title "Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism" @default.
• W2802398839 cites W1009897166 @default.
• W2802398839 cites W1524070096 @default.
• W2802398839 cites W1524273338 @default.
• W2802398839 cites W171134882 @default.
• W2802398839 cites W1821012368 @default.
• W2802398839 cites W1829185341 @default.
• W2802398839 cites W1869544959 @default.
• W2802398839 cites W1883566698 @default.
• W2802398839 cites W1901435509 @default.
• W2802398839 cites W1928496153 @default.
• W2802398839 cites W1959518630 @default.
• W2802398839 cites W1963588613 @default.
• W2802398839 cites W1967917438 @default.
• W2802398839 cites W1970972871 @default.
• W2802398839 cites W1974465665 @default.
• W2802398839 cites W1975638885 @default.
• W2802398839 cites W1976100625 @default.
• W2802398839 cites W1979959607 @default.
• W2802398839 cites W1980050771 @default.
• W2802398839 cites W1980704224 @default.
• W2802398839 cites W1985839994 @default.
• W2802398839 cites W1986644762 @default.
• W2802398839 cites W1988410628 @default.
• W2802398839 cites W1988783094 @default.
• W2802398839 cites W2000755834 @default.
• W2802398839 cites W2002664615 @default.
• W2802398839 cites W2005365566 @default.
• W2802398839 cites W2007115125 @default.
• W2802398839 cites W2012047680 @default.
• W2802398839 cites W2012490955 @default.
• W2802398839 cites W2013700693 @default.
• W2802398839 cites W2013906908 @default.
• W2802398839 cites W2014444288 @default.
• W2802398839 cites W2017280433 @default.
• W2802398839 cites W2018856494 @default.
• W2802398839 cites W2020523926 @default.
• W2802398839 cites W2021281320 @default.
• W2802398839 cites W2028901643 @default.
• W2802398839 cites W2030500910 @default.
• W2802398839 cites W2031102596 @default.
• W2802398839 cites W2037217363 @default.
• W2802398839 cites W2043941700 @default.
• W2802398839 cites W2047668501 @default.
• W2802398839 cites W2048169382 @default.
• W2802398839 cites W2053695875 @default.
• W2802398839 cites W2055091062 @default.
• W2802398839 cites W2060785552 @default.
• W2802398839 cites W2060915038 @default.
• W2802398839 cites W2061239292 @default.
• W2802398839 cites W2068197112 @default.
• W2802398839 cites W2074256369 @default.
• W2802398839 cites W2079072904 @default.
• W2802398839 cites W2082548421 @default.
• W2802398839 cites W2082578477 @default.
• W2802398839 cites W2083659928 @default.
• W2802398839 cites W2092569407 @default.
• W2802398839 cites W2099856240 @default.
• W2802398839 cites W2101209169 @default.
• W2802398839 cites W2101481997 @default.
• W2802398839 cites W2103294794 @default.
• W2802398839 cites W2104164296 @default.
• W2802398839 cites W2105180380 @default.
• W2802398839 cites W2106798170 @default.
• W2802398839 cites W2108734701 @default.
• W2802398839 cites W2109664460 @default.
• W2802398839 cites W2110936821 @default.
• W2802398839 cites W2113675370 @default.
• W2802398839 cites W2122937307 @default.
• W2802398839 cites W2125042686 @default.
• W2802398839 cites W2126570610 @default.
• W2802398839 cites W2127318070 @default.
• W2802398839 cites W2135232490 @default.
• W2802398839 cites W2135802167 @default.
• W2802398839 cites W2144133378 @default.
• W2802398839 cites W2145519613 @default.
• W2802398839 cites W2147163130 @default.
• W2802398839 cites W2147678069 @default.
• W2802398839 cites W2149973964 @default.
• W2802398839 cites W2155900825 @default.
• W2802398839 cites W2156464405 @default.
• W2802398839 cites W2161140251 @default.
• W2802398839 cites W2162704444 @default.
• W2802398839 cites W2163485668 @default.
• W2802398839 cites W2166701473 @default.

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