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- W2802441120 abstract "This work aims to study the roles and mechanisms of metformin in glioma cells stemness and epithelial-mesenchymal transition. Here, we found that metformin suppressed glioma cells spheroid formation and size, inhibited the expression of glioma stemness-related marker, CD133. Additionally, Metformin attenuated TGF-β-induced epithelial-mesenchymal transition in glioma cells. Mechanistically, metformin inhibited the nuclear abundance of YAP, a key effector of Hippo pathway, subsequently leading to its cytoplasmic retention, and thus reduced YAP transcriptional modulating activity. Importantly, overexpression of a mutant form of YAP (YAP-5SA) attenuated the inhibition of metformin on glioma cells stemness and epithelial-mesenchymal transition. Thus, metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity." @default.
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- W2802441120 date "2018-06-01" @default.
- W2802441120 modified "2023-09-27" @default.
- W2802441120 title "Metformin inhibits glioma cells stemness and epithelial-mesenchymal transition via regulating YAP activity" @default.
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- W2802441120 doi "https://doi.org/10.1016/j.biopha.2018.03.031" @default.
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