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- W2802474812 startingPage "605" @default.
- W2802474812 abstract "The vine stem of Spatholobus suberectus Dunn (SS) is used as a traditional herbal medicine in China. Chinese herbal medicines are well known as natural bioactive compounds that can be used as new medicines, and their antioxidant and anticancer effects have also been reported. This study aimed to examine the anticancer effect of a high-pressure hot-water SS extract on rat C6 glioma cells. The SS extract effectively suppressed the viability and proliferation of C6 glioma cells through an antioxidant effect. Reactive oxygen species (ROS) levels in cancer cells are higher than that in normal cells. If the ROS level falls below that required for the growth of cancer cells, their rapid proliferation and growth can be suppressed. We also measured the induction of mitochondrial membrane depolarization and cell cycle arrest effect caused by the SS extract in C6 glioma cells through a FACS analysis. In addition, we observed an increase in STAT3, p53, E2F1, and p21 mRNA expression and a decrease in Bcl-2 mRNA expression by quantitative PCR. An increase in p21 protein expression of over 83% was observed through western blot analysis. All these data support the fact that the high-pressure hot-water SS extract has the potential to be used for glioma treatment." @default.
- W2802474812 created "2018-05-17" @default.
- W2802474812 creator A5030311881 @default.
- W2802474812 creator A5037681035 @default.
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- W2802474812 creator A5050694512 @default.
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- W2802474812 creator A5064879242 @default.
- W2802474812 creator A5074946587 @default.
- W2802474812 creator A5084283705 @default.
- W2802474812 date "2018-04-18" @default.
- W2802474812 modified "2023-10-01" @default.
- W2802474812 title "Antiproliferative Effect of Vine Stem Extract from<i>Spatholobus Suberectus</i>Dunn on Rat C6 Glioma Cells Through Regulation of ROS, Mitochondrial Depolarization, and P21 Protein Expression" @default.
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