Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802487994> ?p ?o ?g. }
- W2802487994 endingPage "5009" @default.
- W2802487994 startingPage "5004" @default.
- W2802487994 abstract "Significance Tonic inhibition plays critical roles in cognitive functions under physiological and pathological conditions by controlling neuronal excitability. Although we have previously reported that cerebellar tonic inhibition is critically dependent on both the synthesis of GABA through monoamine oxidase B (MAOB) enzyme and the release via the bestrophin 1 (Best1) channel, the role of astrocytic GABA in cerebellar function in vivo has remained elusive. Here, we report that a reduction of tonic GABA release by genetic or pharmacological removal of Best1 or MAOB caused enhanced neuronal excitability, synaptic transmission, and motor performance on the rotarod test, whereas an augmentation of tonic GABA release by astrocyte-specific overexpression of MAOB caused opposite results. Our findings suggest the actions of astrocytic GABA in excitation/inhibition balance and motor coordination." @default.
- W2802487994 created "2018-05-17" @default.
- W2802487994 creator A5006210358 @default.
- W2802487994 creator A5009423272 @default.
- W2802487994 creator A5009471632 @default.
- W2802487994 creator A5010769829 @default.
- W2802487994 creator A5011459124 @default.
- W2802487994 creator A5022282943 @default.
- W2802487994 creator A5025725909 @default.
- W2802487994 creator A5047012149 @default.
- W2802487994 creator A5055729234 @default.
- W2802487994 creator A5063520819 @default.
- W2802487994 creator A5076667899 @default.
- W2802487994 creator A5079023479 @default.
- W2802487994 creator A5088599508 @default.
- W2802487994 creator A5089185784 @default.
- W2802487994 date "2018-04-24" @default.
- W2802487994 modified "2023-10-10" @default.
- W2802487994 title "Control of motor coordination by astrocytic tonic GABA release through modulation of excitation/inhibition balance in cerebellum" @default.
- W2802487994 cites W1550227666 @default.
- W2802487994 cites W1597104932 @default.
- W2802487994 cites W1905103140 @default.
- W2802487994 cites W1970760008 @default.
- W2802487994 cites W1975356290 @default.
- W2802487994 cites W1975706895 @default.
- W2802487994 cites W1980138521 @default.
- W2802487994 cites W1983120762 @default.
- W2802487994 cites W1991128766 @default.
- W2802487994 cites W1994532676 @default.
- W2802487994 cites W1996353639 @default.
- W2802487994 cites W1998290119 @default.
- W2802487994 cites W1998383469 @default.
- W2802487994 cites W2000225222 @default.
- W2802487994 cites W2003593144 @default.
- W2802487994 cites W2006461738 @default.
- W2802487994 cites W2016321438 @default.
- W2802487994 cites W2021194790 @default.
- W2802487994 cites W2039424996 @default.
- W2802487994 cites W2040774933 @default.
- W2802487994 cites W2065031748 @default.
- W2802487994 cites W2072962057 @default.
- W2802487994 cites W2081322688 @default.
- W2802487994 cites W2086126018 @default.
- W2802487994 cites W2108916755 @default.
- W2802487994 cites W2116447221 @default.
- W2802487994 cites W2131584208 @default.
- W2802487994 cites W2132457456 @default.
- W2802487994 cites W2134172496 @default.
- W2802487994 cites W2135382901 @default.
- W2802487994 cites W2142169831 @default.
- W2802487994 cites W2147502381 @default.
- W2802487994 cites W2154490775 @default.
- W2802487994 cites W2164752954 @default.
- W2802487994 cites W2333165720 @default.
- W2802487994 cites W2403462825 @default.
- W2802487994 cites W2498568960 @default.
- W2802487994 cites W2514779583 @default.
- W2802487994 cites W3172905145 @default.
- W2802487994 doi "https://doi.org/10.1073/pnas.1721187115" @default.
- W2802487994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5948981" @default.
- W2802487994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29691318" @default.
- W2802487994 hasPublicationYear "2018" @default.
- W2802487994 type Work @default.
- W2802487994 sameAs 2802487994 @default.
- W2802487994 citedByCount "70" @default.
- W2802487994 countsByYear W28024879942018 @default.
- W2802487994 countsByYear W28024879942019 @default.
- W2802487994 countsByYear W28024879942020 @default.
- W2802487994 countsByYear W28024879942021 @default.
- W2802487994 countsByYear W28024879942022 @default.
- W2802487994 countsByYear W28024879942023 @default.
- W2802487994 crossrefType "journal-article" @default.
- W2802487994 hasAuthorship W2802487994A5006210358 @default.
- W2802487994 hasAuthorship W2802487994A5009423272 @default.
- W2802487994 hasAuthorship W2802487994A5009471632 @default.
- W2802487994 hasAuthorship W2802487994A5010769829 @default.
- W2802487994 hasAuthorship W2802487994A5011459124 @default.
- W2802487994 hasAuthorship W2802487994A5022282943 @default.
- W2802487994 hasAuthorship W2802487994A5025725909 @default.
- W2802487994 hasAuthorship W2802487994A5047012149 @default.
- W2802487994 hasAuthorship W2802487994A5055729234 @default.
- W2802487994 hasAuthorship W2802487994A5063520819 @default.
- W2802487994 hasAuthorship W2802487994A5076667899 @default.
- W2802487994 hasAuthorship W2802487994A5079023479 @default.
- W2802487994 hasAuthorship W2802487994A5088599508 @default.
- W2802487994 hasAuthorship W2802487994A5089185784 @default.
- W2802487994 hasBestOaLocation W28024879941 @default.
- W2802487994 hasConcept C113062710 @default.
- W2802487994 hasConcept C127573956 @default.
- W2802487994 hasConcept C169760540 @default.
- W2802487994 hasConcept C170493617 @default.
- W2802487994 hasConcept C185592680 @default.
- W2802487994 hasConcept C200170125 @default.
- W2802487994 hasConcept C2779652256 @default.
- W2802487994 hasConcept C55493867 @default.
- W2802487994 hasConcept C86803240 @default.
- W2802487994 hasConceptScore W2802487994C113062710 @default.
- W2802487994 hasConceptScore W2802487994C127573956 @default.