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• W2802494512 abstract "Background Recent studies have found circular RNA s (circ RNA s) involved in the biological process of cancers. However, little is known about their functional roles in glioblastoma. Methods Human circ RNA microarray analysis was performed to screen the expression profile of circ RNA s in IDH 1 wild‐type glioblastoma tissue. The expression of hsa_circ_0008344 in glioblastoma and normal brain samples was quantified by qRT ‐ PCR . Functional experiments were performed to investigate the biological functions of hsa_circ_0008344, including MTT assay, colony formation assay, transwell assay, and cell apoptosis assay. Results Circ RNA microarray revealed a total of 417 abnormally expressed circ RNA s (>1.5‐fold, P < .05) in glioblastoma tissue compared with the adjacent normal brain. Hsa_circ_0008344, among the top differentially expressed circ RNA s, was significantly upregulated in IDH 1 wild‐type glioblastoma. Further in vitro studies showed that knockdown of hsa_circ_0008344 suppressed glioblastoma cell proliferation, colony formation, migration, and invasion, but increased cell apoptotic rate. Conclusions Hsa_circ_0008344 is upregulated in glioblastoma and may contribute to the progression of this malignancy." @default.
• W2802494512 created "2018-05-17" @default.
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• W2802494512 date "2018-04-24" @default.
• W2802494512 modified "2023-10-17" @default.
• W2802494512 title "Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis" @default.
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• W2802494512 doi "https://doi.org/10.1002/jcla.22454" @default.
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