Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802503852> ?p ?o ?g. }
- W2802503852 endingPage "e201800059" @default.
- W2802503852 startingPage "e201800059" @default.
- W2802503852 abstract "Microtubules are highly dynamic structures that play an integral role in fundamental cellular functions. Different α- and β-tubulin isotypes are thought to confer unique dynamic properties to microtubules. The tubulin isotypes have highly conserved structures, differing mainly in their carboxy-terminal (C-terminal) tail sequences. However, little is known about the importance of the C-terminal tail in regulating and coordinating microtubule dynamics. We developed syngeneic human cell models using gene editing to precisely modify the β-tubulin C-terminal tail region while preserving the endogenous microtubule network. Fluorescent microscopy of live cells, coupled with advanced image analysis, revealed that the β-tubulin C-terminal tails differentially coordinate the collective and individual dynamic behavior of microtubules by affecting microtubule growth rates and explorative microtubule assembly in an isotype-specific manner. Furthermore, βI- and βIII-tubulin C-terminal tails differentially regulate the sensitivity of microtubules to tubulin-binding agents and the microtubule depolymerizing protein mitotic centromere-associated kinesin. The sequence of the β-tubulin tail encodes regulatory information that instructs and coordinates microtubule dynamics, thereby fine-tuning microtubule dynamics to support cellular functions." @default.
- W2802503852 created "2018-05-17" @default.
- W2802503852 creator A5007943885 @default.
- W2802503852 creator A5017575360 @default.
- W2802503852 creator A5026784302 @default.
- W2802503852 creator A5051655023 @default.
- W2802503852 creator A5053848493 @default.
- W2802503852 creator A5084697894 @default.
- W2802503852 creator A5085362634 @default.
- W2802503852 date "2018-04-19" @default.
- W2802503852 modified "2023-10-18" @default.
- W2802503852 title "β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells" @default.
- W2802503852 cites W1513725475 @default.
- W2802503852 cites W1551578308 @default.
- W2802503852 cites W1552240777 @default.
- W2802503852 cites W1559172215 @default.
- W2802503852 cites W1568563634 @default.
- W2802503852 cites W1669628807 @default.
- W2802503852 cites W1965218509 @default.
- W2802503852 cites W1974025012 @default.
- W2802503852 cites W1979705699 @default.
- W2802503852 cites W1980257624 @default.
- W2802503852 cites W1983184181 @default.
- W2802503852 cites W1985501881 @default.
- W2802503852 cites W1988963409 @default.
- W2802503852 cites W1991863200 @default.
- W2802503852 cites W1996491270 @default.
- W2802503852 cites W2007917102 @default.
- W2802503852 cites W2026682681 @default.
- W2802503852 cites W2033546221 @default.
- W2802503852 cites W2037066635 @default.
- W2802503852 cites W2037962515 @default.
- W2802503852 cites W2041976798 @default.
- W2802503852 cites W2044820159 @default.
- W2802503852 cites W2046092556 @default.
- W2802503852 cites W2048454522 @default.
- W2802503852 cites W2049351325 @default.
- W2802503852 cites W2050285145 @default.
- W2802503852 cites W2054271542 @default.
- W2802503852 cites W2055851342 @default.
- W2802503852 cites W2059842692 @default.
- W2802503852 cites W2066810065 @default.
- W2802503852 cites W2068676622 @default.
- W2802503852 cites W2069107536 @default.
- W2802503852 cites W2069400786 @default.
- W2802503852 cites W2071817332 @default.
- W2802503852 cites W2075993250 @default.
- W2802503852 cites W2081455193 @default.
- W2802503852 cites W2081938650 @default.
- W2802503852 cites W2084223205 @default.
- W2802503852 cites W2084626189 @default.
- W2802503852 cites W2093088276 @default.
- W2802503852 cites W2096915140 @default.
- W2802503852 cites W2105615050 @default.
- W2802503852 cites W2107554012 @default.
- W2802503852 cites W2109129712 @default.
- W2802503852 cites W2115843648 @default.
- W2802503852 cites W2116494721 @default.
- W2802503852 cites W2117130243 @default.
- W2802503852 cites W2121302141 @default.
- W2802503852 cites W2123211763 @default.
- W2802503852 cites W2123542003 @default.
- W2802503852 cites W2134443458 @default.
- W2802503852 cites W2137262057 @default.
- W2802503852 cites W2140460884 @default.
- W2802503852 cites W2146412869 @default.
- W2802503852 cites W2156419662 @default.
- W2802503852 cites W2159712725 @default.
- W2802503852 cites W2167664436 @default.
- W2802503852 cites W2167739777 @default.
- W2802503852 cites W2169668454 @default.
- W2802503852 cites W2344733175 @default.
- W2802503852 cites W2346643966 @default.
- W2802503852 cites W2406661668 @default.
- W2802503852 cites W2513380695 @default.
- W2802503852 cites W2523269553 @default.
- W2802503852 cites W2529052661 @default.
- W2802503852 cites W2596122988 @default.
- W2802503852 cites W2596255045 @default.
- W2802503852 cites W2602849150 @default.
- W2802503852 cites W4210300859 @default.
- W2802503852 cites W4233933472 @default.
- W2802503852 cites W59603351 @default.
- W2802503852 doi "https://doi.org/10.26508/lsa.201800059" @default.
- W2802503852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6070155" @default.
- W2802503852 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30079401" @default.
- W2802503852 hasPublicationYear "2018" @default.
- W2802503852 type Work @default.
- W2802503852 sameAs 2802503852 @default.
- W2802503852 citedByCount "16" @default.
- W2802503852 countsByYear W28025038522019 @default.
- W2802503852 countsByYear W28025038522020 @default.
- W2802503852 countsByYear W28025038522021 @default.
- W2802503852 countsByYear W28025038522022 @default.
- W2802503852 countsByYear W28025038522023 @default.
- W2802503852 crossrefType "journal-article" @default.
- W2802503852 hasAuthorship W2802503852A5007943885 @default.
- W2802503852 hasAuthorship W2802503852A5017575360 @default.