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- W2802509574 abstract "Tenofovir disoproxil fumarate tablets and the combination tablets that contain that agent plus emtricitabine may be administered enterally in crushed form and maintain suppression of viral load in patients with HIV infection.1 It is generally recommended to crush these tablets and mix with 60 mL of warm water if they must be given via feeding tube.1,2 Tenofovir alafenamide, a novel tenofovir salt that produces plasma tenofovir concentrations that are 91% lower than tenofovir disoproxil fumarate, is available in tablets for the treatment of hepatitis B and in a combination tablet with emtricitabine for HIV-positive patients.3,4 Compared with tenofovir disoproxil fumarate, the use of tenofovir alafenamide with emtricitabine results in a lower degree of urinary protein elimination and less reduction of bone mineral density.5 A regimen consisting of tenofovir alafenamide with emtricitabine plus integrase strand transfer inhibitors is recommended for use in most patients with HIV as an alternative to tenofovir disoproxil fumarate with emtricitabine.6 No data exist on the effectiveness of crushed combination tablets containing tenofovir alafenamide and emtricitabine. We describe the successful administration of these crushed tablets, combined with dolutegravir, in a patient with a gastrostomy tube." @default.
- W2802509574 created "2018-05-17" @default.
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- W2802509574 date "2018-05-15" @default.
- W2802509574 modified "2023-10-01" @default.
- W2802509574 title "Enhanced HIV viral load suppression with crushed combination tablets containing tenofovir alafenamide and emtricitabine" @default.
- W2802509574 cites W2077535491 @default.
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- W2802509574 doi "https://doi.org/10.2146/180090" @default.
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