FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802530189> ?p ?o ?g. }

• W2802530189 endingPage "269" @default.
• W2802530189 startingPage "253" @default.
• W2802530189 abstract "Extended-spectrum β-lactamases (ESBLs) and/or AmpC enzymes combined with deficiency of porins OmpK35 and OmpK36 are important for the development of carbapenem-resistant Klebsiella pneumoniae. We characterized the clinical K. pneumoniae human isolates and investigated the effect of meropenem induction on the ompK35 and ompK36 mutation to develop carbapenem resistance from six carbapenem-susceptible ESBL-producing K. pneumoniae strains. 163 clinical K. pneumoniae isolates were grouped mostly into the ESBL + AmpC (44.2%) and ESBL (42.9%) phenotypes. The resistance rate differed between cephalosporins (52.1% for cefepime - 97.5% for cefotaxime) and carbapenems (16% for meropenem - 28.2% for imipenem) (P blaTEM, blaSHV, blaCTX-M-3-like, and blaCTX-M-14-like of AmpA β-lactamase genes and blaDHA and blaCMY of AmpC β-lactamase genes. Compared to all 163 clinical isolates, the 56 carbapenem-resistant isolates carried less frequently of blaTEM, blaCTXM-14-like, and blaCTXM-3-like and more frequently of blaDHA-1 and blaCMY-2. The carbapenem-resistant isolates differed in prevalence against imipenem, ertapenem, and meropenem and lacked OmpK35 more frequently than OmpK36, but abnormal PCR amplicons were detected fewer in the Omp K35-deficient group than in the OmpK36-deficient group (32.5% vs. 68.4%, respectively). The carbapenem-resistant isolate mostly carried blaDHA (91.1%) and three isolates carried blaKPC-2. Following induction with meropenem insertion sequences in ompK36, not ompK36, were identified as IS5 for KP08, IS1 for KP15, and IS903 for KP16 isolates. OmpK36 deficiency increased resistance to ertapenem, but not imipenem and meropenem. Clinical isolates belonged mainly to ESBL + AmpC group and ESBL group with difference in resistance to cephalosporins and carbapenems, the bla genes. Carbapenem resistant isolates lacked OmpK35 expression, than the OmpK36 expression, Meropenem induction developed the carbapenem resistant isolates with insertion of different insertion sequences in ompK36, not ompK35." @default.
• W2802530189 created "2018-05-17" @default.
• W2802530189 creator A5043812095 @default.
• W2802530189 creator A5049086826 @default.
• W2802530189 creator A5070917399 @default.
• W2802530189 creator A5080665981 @default.
• W2802530189 creator A5088352015 @default.
• W2802530189 creator A5090866474 @default.
• W2802530189 date "2018-01-01" @default.
• W2802530189 modified "2023-10-14" @default.
• W2802530189 title "Insertion Sequence-Dependent &lt;i&gt;OmpK&lt;/i&gt;36 Mutation Associated Ertapenem Resistance in Clinical &lt;i&gt;Klebsiella pneumoniae&lt;/i&gt;" @default.
• W2802530189 cites W1965334254 @default.
• W2802530189 cites W1972175795 @default.
• W2802530189 cites W1973757539 @default.
• W2802530189 cites W1996487927 @default.
• W2802530189 cites W2006425696 @default.
• W2802530189 cites W2007225459 @default.
• W2802530189 cites W2008881965 @default.
• W2802530189 cites W2009004269 @default.
• W2802530189 cites W2030963088 @default.
• W2802530189 cites W2058796042 @default.
• W2802530189 cites W2061042718 @default.
• W2802530189 cites W2061729558 @default.
• W2802530189 cites W2067002340 @default.
• W2802530189 cites W2072511609 @default.
• W2802530189 cites W2089885661 @default.
• W2802530189 cites W2091038487 @default.
• W2802530189 cites W2095782411 @default.
• W2802530189 cites W2099001508 @default.
• W2802530189 cites W2099303284 @default.
• W2802530189 cites W2101652574 @default.
• W2802530189 cites W2103162870 @default.
• W2802530189 cites W2104531279 @default.
• W2802530189 cites W2106982371 @default.
• W2802530189 cites W2107500510 @default.
• W2802530189 cites W2112337702 @default.
• W2802530189 cites W2118051571 @default.
• W2802530189 cites W2120014539 @default.
• W2802530189 cites W2123677996 @default.
• W2802530189 cites W2125893214 @default.
• W2802530189 cites W2126773629 @default.
• W2802530189 cites W2131653943 @default.
• W2802530189 cites W2132457720 @default.
• W2802530189 cites W2140604551 @default.
• W2802530189 cites W2141771577 @default.
• W2802530189 cites W2143882330 @default.
• W2802530189 cites W2147117435 @default.
• W2802530189 cites W2154981049 @default.
• W2802530189 cites W2154994569 @default.
• W2802530189 cites W2163232478 @default.
• W2802530189 cites W2163832044 @default.
• W2802530189 cites W2167963429 @default.
• W2802530189 cites W2169680194 @default.
• W2802530189 cites W2196782563 @default.
• W2802530189 cites W2281634804 @default.
• W2802530189 cites W2402886951 @default.
• W2802530189 cites W2522275690 @default.
• W2802530189 cites W2544283876 @default.
• W2802530189 doi "https://doi.org/10.4236/aim.2018.84017" @default.
• W2802530189 hasPublicationYear "2018" @default.
• W2802530189 type Work @default.
• W2802530189 sameAs 2802530189 @default.
• W2802530189 citedByCount "2" @default.
• W2802530189 countsByYear W28025301892022 @default.
• W2802530189 countsByYear W28025301892023 @default.
• W2802530189 crossrefType "journal-article" @default.
• W2802530189 hasAuthorship W2802530189A5043812095 @default.
• W2802530189 hasAuthorship W2802530189A5049086826 @default.
• W2802530189 hasAuthorship W2802530189A5070917399 @default.
• W2802530189 hasAuthorship W2802530189A5080665981 @default.
• W2802530189 hasAuthorship W2802530189A5088352015 @default.
• W2802530189 hasAuthorship W2802530189A5090866474 @default.
• W2802530189 hasBestOaLocation W28025301891 @default.
• W2802530189 hasConcept C104317684 @default.
• W2802530189 hasConcept C2776685102 @default.
• W2802530189 hasConcept C2777050379 @default.
• W2802530189 hasConcept C2777058267 @default.
• W2802530189 hasConcept C2778368673 @default.
• W2802530189 hasConcept C2778719061 @default.
• W2802530189 hasConcept C2779375183 @default.
• W2802530189 hasConcept C2779631663 @default.
• W2802530189 hasConcept C501593827 @default.
• W2802530189 hasConcept C54355233 @default.
• W2802530189 hasConcept C547475151 @default.
• W2802530189 hasConcept C64778159 @default.
• W2802530189 hasConcept C86803240 @default.
• W2802530189 hasConcept C89423630 @default.
• W2802530189 hasConcept C94665300 @default.
• W2802530189 hasConceptScore W2802530189C104317684 @default.
• W2802530189 hasConceptScore W2802530189C2776685102 @default.
• W2802530189 hasConceptScore W2802530189C2777050379 @default.
• W2802530189 hasConceptScore W2802530189C2777058267 @default.
• W2802530189 hasConceptScore W2802530189C2778368673 @default.
• W2802530189 hasConceptScore W2802530189C2778719061 @default.
• W2802530189 hasConceptScore W2802530189C2779375183 @default.
• W2802530189 hasConceptScore W2802530189C2779631663 @default.
• W2802530189 hasConceptScore W2802530189C501593827 @default.
• W2802530189 hasConceptScore W2802530189C54355233 @default.

• next