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- W2802547370 abstract "Our objective was to determine whether, compared with control interventions, pharmacologic interventions reduce the severity of fatigue in patients with cancer or recipients of hematopoietic stem-cell transplantation (hsct).For a systematic review, we searched medline, embase, the Cochrane Central Register of Controlled Trials, cinahl, and Psychinfo for randomized trials of systemic pharmacologic interventions for the management of fatigue in patients with cancer or recipients of hsct. Two authors independently identified studies and abstracted data. Methodologic quality was assessed using the Cochrane Risk of Bias tool. The primary outcome was fatigue severity measured using various fatigue scales. Data were synthesized using random-effects models.In the 117 included trials (19,819 patients), the pharmacologic agents used were erythropoietins (n = 31), stimulants (n = 19), l-carnitine (n = 6), corticosteroids (n = 5), antidepressants (n = 5), appetite stimulants (n = 3), and other agents (n = 48). Fatigue was significantly reduced with erythropoietin [standardized mean difference (smd): -0.52; 95% confidence interval (ci): -0.89 to -0.14] and with methylphenidate (smd: -0.36; 95% ci: -0.56 to -0.15); modafinil (or armodafinil) and corticosteroids were not effective.Erythropoietin and methylphenidate significantly reduced fatigue severity in patients with cancer and in recipients of hsct. Concerns about the safety of those agents might limit their usefulness. Future research should identify effective interventions for fatigue that have minimal adverse effects." @default.
- W2802547370 created "2018-05-17" @default.
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- W2802547370 date "2018-04-01" @default.
- W2802547370 modified "2023-10-12" @default.
- W2802547370 title "Pharmacologic Interventions for Fatigue in Cancer and Transplantation: A Meta-Analysis" @default.
- W2802547370 cites W1499455897 @default.
- W2802547370 cites W1509242347 @default.
- W2802547370 cites W1518728900 @default.
- W2802547370 cites W1687081113 @default.
- W2802547370 cites W1835001492 @default.
- W2802547370 cites W188424385 @default.
- W2802547370 cites W1885881044 @default.
- W2802547370 cites W1916116557 @default.
- W2802547370 cites W1952315861 @default.
- W2802547370 cites W1963612467 @default.
- W2802547370 cites W1964151928 @default.
- W2802547370 cites W1964441052 @default.
- W2802547370 cites W1966614057 @default.
- W2802547370 cites W1967603453 @default.
- W2802547370 cites W1969065116 @default.
- W2802547370 cites W1969222077 @default.
- W2802547370 cites W1969913701 @default.
- W2802547370 cites W1972479281 @default.
- W2802547370 cites W1978267073 @default.
- W2802547370 cites W1979666460 @default.
- W2802547370 cites W1980023043 @default.
- W2802547370 cites W1983769010 @default.
- W2802547370 cites W1984143791 @default.
- W2802547370 cites W1988542699 @default.
- W2802547370 cites W1988929378 @default.
- W2802547370 cites W1989139859 @default.
- W2802547370 cites W1992903256 @default.
- W2802547370 cites W1992982100 @default.
- W2802547370 cites W1993262172 @default.
- W2802547370 cites W1993445508 @default.
- W2802547370 cites W1994548350 @default.
- W2802547370 cites W1996698172 @default.
- W2802547370 cites W1997788473 @default.
- W2802547370 cites W1998987756 @default.
- W2802547370 cites W2002395765 @default.
- W2802547370 cites W2003978548 @default.
- W2802547370 cites W2003982930 @default.
- W2802547370 cites W2007957803 @default.
- W2802547370 cites W2008588675 @default.
- W2802547370 cites W2009635471 @default.
- W2802547370 cites W2009789178 @default.
- W2802547370 cites W2011932878 @default.
- W2802547370 cites W2017578928 @default.
- W2802547370 cites W2023686483 @default.
- W2802547370 cites W2026616886 @default.
- W2802547370 cites W2028242201 @default.
- W2802547370 cites W2029321962 @default.
- W2802547370 cites W2029950111 @default.
- W2802547370 cites W2030211882 @default.
- W2802547370 cites W2031792644 @default.
- W2802547370 cites W2033523320 @default.
- W2802547370 cites W2033585778 @default.
- W2802547370 cites W2037288900 @default.
- W2802547370 cites W2040920281 @default.
- W2802547370 cites W2042662251 @default.
- W2802547370 cites W2042933187 @default.
- W2802547370 cites W2044782312 @default.
- W2802547370 cites W2046122149 @default.
- W2802547370 cites W2047978423 @default.
- W2802547370 cites W2050763541 @default.
- W2802547370 cites W2060861099 @default.
- W2802547370 cites W2060869681 @default.
- W2802547370 cites W2061029651 @default.
- W2802547370 cites W2061923351 @default.
- W2802547370 cites W2064039263 @default.
- W2802547370 cites W2067322982 @default.
- W2802547370 cites W2067623167 @default.
- W2802547370 cites W2071952903 @default.
- W2802547370 cites W2074014039 @default.
- W2802547370 cites W2078008101 @default.
- W2802547370 cites W2078854267 @default.
- W2802547370 cites W2081203495 @default.
- W2802547370 cites W2083606633 @default.
- W2802547370 cites W2085752184 @default.
- W2802547370 cites W2087778234 @default.
- W2802547370 cites W2088041869 @default.
- W2802547370 cites W2089524549 @default.
- W2802547370 cites W2091580529 @default.