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- W2802549971 abstract "Chronic kidney disease-associated pruritus (CKD-aP) is a debilitating chronic itching condition frequently reported in end stage renal disease patients, with no approved treatments in the United States (US). As the sensation of itching can only be assessed by patient report, reliable, valid and sensitive patient-reported outcomes (PROs) are required to demonstrate treatment benefits in studies of therapies under development for treatment of pruritus in hemodialysis (HD) patients. The purpose of this study was to conduct qualitative interviews in HD patients to evaluate the content validity of two existing PRO instruments, the Worst Itching Intensity Numerical Rating Scale (NRS) to measure itch intensity and the Skindex-10 scale to assess itch-related quality of life (QoL) measures including mood and social functioning. One-on-one interviews were conducted in 23 HD patients in the US suffering from mild to severe chronic itch to assess the important concepts related to CKD-aP and the appropriateness of the PRO instruments. HD patients [25 to 82 years old, mostly males (61%)] reported daily itching (52%) on the back (65%), arms (57%), head (48%), and legs (43%) with worst itching at night (61%), and during or after dialysis (30%). All participants reported feeling bothered by their itching with difficulties carrying out daily activities (e.g., bathing, running errands, housework) (87%), sleep disturbance (83%), and emotional/psychological (39%) impacts. Patients reported that the content of the NRS and Skindex-10 was clear, comprehensive, and relevant to their itch, including instructions, item wording, recall period and response options. This study emphasizes the impact of pruritus on health-related QoL in HD patients and supports the use of the NRS and Skindex-10 PRO instruments to evaluate the symptoms of CKD-aP and treatment benefits in trial and treatment settings." @default.
- W2802549971 created "2018-05-17" @default.
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- W2802549971 date "2018-05-01" @default.
- W2802549971 modified "2023-09-26" @default.
- W2802549971 title "582 Measurement of pruritus associated with chronic kidney disease: A qualitative study of two patient-reported outcome instruments" @default.
- W2802549971 doi "https://doi.org/10.1016/j.jid.2018.03.590" @default.
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