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- W2802557324 abstract "Lipid mediators play an important role as biological messengers involved in inflammatory processes. Deriving from different polyunsaturated fatty acids, endogenously built mediators featuring both pro- and anti-inflammatory properties as well as pro-resolving lipid mediators and their biological precursors have been investigated. A newly developed method using chiral chromatography-tandem mass spectrometry on human plasma has demonstrated its suitability for the simultaneous determination of prostaglandins, lipoxins, D-series derived resolvins as well as protectins, maresin 1, leukotriene B4 and several precursors of them in order to yield information about metabolic pathways. Due to the matrix complexity, a solid phase extraction method using an octadecyl-modified silica gel cartridge was carried out. The developed method allows the determination of 34 analytes in 25 min showing enough selectivity as well as precision and accuracy (≤15% relative standard deviation, ≤15% relative error) in the calibration range of 0.1–10 ng mL−1 or 0.2–20 ng mL−1 depending on the analytes. Stability of the analytes in plasma has been demonstrated for at least 3 h at room temperature, 72 h in the autosampler and 60 days in the freezer at −80 °C. This method has been validated and shown its suitability for the determination of all studied analytes in human plasma samples." @default.
- W2802557324 created "2018-05-17" @default.
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- W2802557324 date "2018-11-01" @default.
- W2802557324 modified "2023-10-16" @default.
- W2802557324 title "Simultaneous determination of PUFA-derived pro-resolving metabolites and pathway markers using chiral chromatography and tandem mass spectrometry" @default.
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- W2802557324 doi "https://doi.org/10.1016/j.aca.2018.05.020" @default.
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