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- W2802568982 abstract "G2 and S‐phase expressed 1 ( GTSE 1) regulates cell cycle progression in human cancers. However, its significance and mechanism of action in acral melanoma ( AM ) remain unknown. In the present study, we found that GTSE 1 expression was upregulated in advanced stage/metastatic AM tissues and metastatic cell lines, and correlated with higher stage ( P = .028) and poor disease‐free survival ( DFS ) in patients with AM ( P = .003). Cox regression assays validated GTSE 1 expression to be an independent prognostic factor of DFS for patients with AM ( P = .004). Ectopic expression of GTSE 1 enhanced primary AM cell proliferation, invasion, and migration. Loss‐of‐function in GTSE 1 attenuated metastatic AM cell proliferation and metastatic ability in vitro and in vivo. We additionally observed that inhibition of migration and invasion occurred concomitantly with a GTSE 1 knockdown‐mediated increase in E‐cadherin and decreases in N‐cadherin and Slug. We further showed that integrin subunit alpha 2 ( ITGA 2) interacts with GTSE 1 and is a downstream effector of GTSE 1. Further, ITGA 2 levels were positively correlated with GTSE 1 expression in human AM tissues. Ectopic ITGA 2 expression rescued si GTSE 1‐mediated inhibition of migration and invasion, thereby restoring epithelial‐to‐mesenchymal transition ( EMT ). In conclusion, GTSE 1 expression promotes AM progression and correlates with clinical outcomes of patients with AM , and may represent a promising therapeutic target to suppress AM progression." @default.
- W2802568982 created "2018-05-17" @default.
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- W2802568982 date "2018-05-11" @default.
- W2802568982 modified "2023-10-16" @default.
- W2802568982 title "High G2 and S-phase expressed 1 expression promotes acral melanoma progression and correlates with poor clinical prognosis" @default.
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- W2802568982 doi "https://doi.org/10.1111/cas.13607" @default.
- W2802568982 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5989838" @default.
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