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- W2802602346 endingPage "499" @default.
- W2802602346 startingPage "475" @default.
- W2802602346 abstract "Rhythmicity is a universal timing mechanism in the brain, and the rhythmogenic mechanisms are generally dynamic. This is illustrated for the neuronal control of breathing, a behavior that occurs as a one-, two-, or three-phase rhythm. Each breath is assembled stochastically, and increasing evidence suggests that each phase can be generated independently by a dedicated excitatory microcircuit. Within each microcircuit, rhythmicity emerges through three entangled mechanisms: ( a) glutamatergic transmission, which is amplified by ( b) intrinsic bursting and opposed by ( c) concurrent inhibition. This rhythmogenic triangle is dynamically tuned by neuromodulators and other network interactions. The ability of coupled oscillators to reconfigure and recombine may allow breathing to remain robust yet plastic enough to conform to nonventilatory behaviors such as vocalization, swallowing, and coughing. Lessons learned from the respiratory network may translate to other highly dynamic and integrated rhythmic systems, if approached one breath at a time." @default.
- W2802602346 created "2018-05-17" @default.
- W2802602346 creator A5010756785 @default.
- W2802602346 creator A5069915171 @default.
- W2802602346 date "2018-07-08" @default.
- W2802602346 modified "2023-10-04" @default.
- W2802602346 title "The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time" @default.
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