Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802663922> ?p ?o ?g. }
- W2802663922 endingPage "e000347" @default.
- W2802663922 startingPage "e000347" @default.
- W2802663922 abstract "BackgroundIn the RAISE trial, ramucirumab+leucovorin/fluorouracil/irinotecan (FOLFIRI) improved the median overall survival (mOS) of patients with previously treated metastatic colorectal cancer versus patients treated with placebo+FOLFIRI but had a higher incidence of neutropaenia, leading to more chemotherapy dose modifications and discontinuations. Thus, we conducted an exploratory post-hoc analysis of RAISE and a retrospective, observational analysis of electronic medical record (EMR) data to determine and verify the association of neutropaenia, baseline absolute neutrophil count (ANC) and survival.MethodsThe RAISE analysis used the study safety population (n=1057). IMS Health Oncology Database (IMS EMR) was the source for the real-world data set (n=617).ResultsRAISE patients with treatment-emergent neutropaenia had improved mOS compared with those without (ramucirumab arm: 16.1 vs 10.7 months, HR=0.57, p<0.0001; placebo arm: 12.7 vs 10.7 months, HR=0.76, p=0.0065). RAISE patients with low ANC versus high baseline ANC also had longer mOS (ramucirumab arm: 15.2 vs 8.9 months, HR=0.49, p<0.0001; placebo arm: 13.2 vs 7.3 months, HR=0.50, p<0.0001). The results were similar for IMS EMR low versus high baseline ANC (bevacizumab+FOLFIRI patients: 14.9 vs 7.7 months, HR=0.59, p<0.0001; FOLFIRI alone: 14.6 vs 5.4 months, HR=0.37, p<0.0001). Patients in the RAISE trial with low baseline ANC were more likely to develop neutropaenia (OR: ramucirumab arm=2.62, p<0.0001; placebo arm=2.16, p=0.0003).ConclusionNeutropaenia during treatment, and subsequent dose modifications or discontinuations, do not compromise treatment efficacy. Baseline ANC is a strong prognostic factor for survival and is associated with treatment-emergent neutropaenia in the analysed population.Trial registration numberNCT01183780, Results." @default.
- W2802663922 created "2018-05-17" @default.
- W2802663922 creator A5001591653 @default.
- W2802663922 creator A5007466199 @default.
- W2802663922 creator A5015190461 @default.
- W2802663922 creator A5019380216 @default.
- W2802663922 creator A5023811099 @default.
- W2802663922 creator A5027475930 @default.
- W2802663922 creator A5029670099 @default.
- W2802663922 creator A5031770911 @default.
- W2802663922 creator A5033985179 @default.
- W2802663922 creator A5035278067 @default.
- W2802663922 creator A5052290056 @default.
- W2802663922 creator A5057458005 @default.
- W2802663922 creator A5062748030 @default.
- W2802663922 creator A5073330859 @default.
- W2802663922 creator A5090464803 @default.
- W2802663922 creator A5090645179 @default.
- W2802663922 date "2018-01-01" @default.
- W2802663922 modified "2023-10-16" @default.
- W2802663922 title "Association of baseline absolute neutrophil counts and survival in patients with metastatic colorectal cancer treated with second-line antiangiogenic therapies: exploratory analyses of the RAISE trial and validation in an electronic medical record data set" @default.
- W2802663922 cites W1567249948 @default.
- W2802663922 cites W1982097971 @default.
- W2802663922 cites W1984050453 @default.
- W2802663922 cites W2019067973 @default.
- W2802663922 cites W2023940795 @default.
- W2802663922 cites W2032208962 @default.
- W2802663922 cites W2046881776 @default.
- W2802663922 cites W2091763552 @default.
- W2802663922 cites W2118278569 @default.
- W2802663922 cites W2121847974 @default.
- W2802663922 cites W2123105952 @default.
- W2802663922 cites W2123219164 @default.
- W2802663922 cites W2126252913 @default.
- W2802663922 cites W2157769714 @default.
- W2802663922 cites W2165083157 @default.
- W2802663922 cites W2193074466 @default.
- W2802663922 cites W2237361742 @default.
- W2802663922 cites W2339392565 @default.
- W2802663922 cites W2470477092 @default.
- W2802663922 cites W2490669401 @default.
- W2802663922 cites W2493415491 @default.
- W2802663922 cites W2520028087 @default.
- W2802663922 cites W2586568707 @default.
- W2802663922 cites W2586968316 @default.
- W2802663922 cites W2599676019 @default.
- W2802663922 cites W2915478882 @default.
- W2802663922 cites W49110796 @default.
- W2802663922 doi "https://doi.org/10.1136/esmoopen-2018-000347" @default.
- W2802663922 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5922565" @default.
- W2802663922 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29713498" @default.
- W2802663922 hasPublicationYear "2018" @default.
- W2802663922 type Work @default.
- W2802663922 sameAs 2802663922 @default.
- W2802663922 citedByCount "14" @default.
- W2802663922 countsByYear W28026639222019 @default.
- W2802663922 countsByYear W28026639222020 @default.
- W2802663922 countsByYear W28026639222021 @default.
- W2802663922 countsByYear W28026639222023 @default.
- W2802663922 crossrefType "journal-article" @default.
- W2802663922 hasAuthorship W2802663922A5001591653 @default.
- W2802663922 hasAuthorship W2802663922A5007466199 @default.
- W2802663922 hasAuthorship W2802663922A5015190461 @default.
- W2802663922 hasAuthorship W2802663922A5019380216 @default.
- W2802663922 hasAuthorship W2802663922A5023811099 @default.
- W2802663922 hasAuthorship W2802663922A5027475930 @default.
- W2802663922 hasAuthorship W2802663922A5029670099 @default.
- W2802663922 hasAuthorship W2802663922A5031770911 @default.
- W2802663922 hasAuthorship W2802663922A5033985179 @default.
- W2802663922 hasAuthorship W2802663922A5035278067 @default.
- W2802663922 hasAuthorship W2802663922A5052290056 @default.
- W2802663922 hasAuthorship W2802663922A5057458005 @default.
- W2802663922 hasAuthorship W2802663922A5062748030 @default.
- W2802663922 hasAuthorship W2802663922A5073330859 @default.
- W2802663922 hasAuthorship W2802663922A5090464803 @default.
- W2802663922 hasAuthorship W2802663922A5090645179 @default.
- W2802663922 hasBestOaLocation W28026639221 @default.
- W2802663922 hasConcept C121608353 @default.
- W2802663922 hasConcept C126322002 @default.
- W2802663922 hasConcept C141071460 @default.
- W2802663922 hasConcept C142724271 @default.
- W2802663922 hasConcept C143998085 @default.
- W2802663922 hasConcept C204787440 @default.
- W2802663922 hasConcept C27081682 @default.
- W2802663922 hasConcept C2776694085 @default.
- W2802663922 hasConcept C2776705615 @default.
- W2802663922 hasConcept C2777063308 @default.
- W2802663922 hasConcept C2777802072 @default.
- W2802663922 hasConcept C2779551604 @default.
- W2802663922 hasConcept C2780259306 @default.
- W2802663922 hasConcept C2780456651 @default.
- W2802663922 hasConcept C2780962732 @default.
- W2802663922 hasConcept C2908647359 @default.
- W2802663922 hasConcept C526805850 @default.
- W2802663922 hasConcept C71924100 @default.
- W2802663922 hasConcept C74133956 @default.
- W2802663922 hasConcept C90924648 @default.
- W2802663922 hasConcept C99454951 @default.