FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802666386> ?p ?o ?g. }

• W2802666386 endingPage "1105" @default.
• W2802666386 startingPage "1096" @default.
• W2802666386 abstract "The ATP-binding cassette (ABC) transporter multidrug resistance protein 1 (MRP1/<i>ABCC1</i>) protects cells from arsenic (a proven human carcinogen) through the cellular efflux of arsenic triglutathione [As(GS)₃] and the diglutathione conjugate of monomethylarsonous acid [MMA(GS)₂]. Previously, differences in MRP1 phosphorylation (at Y920/S921) and <i>N</i>-glycosylation (at N19/N23) were associated with marked differences in As(GS)₃ transport kinetics between HEK293 and HeLa cell lines. In the current study, cell line differences in MRP1-mediated cellular protection and transport of other arsenic metabolites were explored. MRP1 expressed in HEK293 cells reduced the toxicity of the major urinary arsenic metabolite dimethylarsinic acid (DMA^V), and HEK-WT-MRP1-enriched vesicles transported DMA^V with high apparent affinity and capacity (<i>K</i>_m 0.19 <i>µ</i>M, <i>V</i>_max 342 pmol⋅mg⁻¹protein⋅min⁻¹). This is the first report that MRP1 is capable of exporting DMA^V, critical for preventing highly toxic dimethylarsinous acid formation. In contrast, DMA^V transport was not detected using HeLa-WT-MRP1 membrane vesicles. MMA(GS)₂ transport by HeLa-WT-MRP1 vesicles had a greater than threefold higher <i>V</i>_max compared with HEK-WT-MRP1 vesicles. Cell line differences in DMA^V and MMA(GS)₂ transport were not explained by differences in phosphorylation at Y920/S921. DMA^V did not inhibit, whereas MMA(GS)₂ was an uncompetitive inhibitor of As(GS)₃ transport, suggesting that DMA^V and MMA(GS)₂ have nonidentical binding sites to As(GS)₃ on MRP1. Efflux of different arsenic metabolites by MRP1 is likely influenced by multiple factors, including cell and tissue type. This could have implications for the impact of MRP1 on both tissue-specific susceptibility to arsenic-induced disease and tumor sensitivity to arsenic-based therapeutics." @default.
• W2802666386 created "2018-05-17" @default.
• W2802666386 creator A5005207927 @default.
• W2802666386 creator A5007283082 @default.
• W2802666386 creator A5021621511 @default.
• W2802666386 creator A5042714572 @default.
• W2802666386 creator A5066932251 @default.
• W2802666386 creator A5090996417 @default.
• W2802666386 date "2018-05-11" @default.
• W2802666386 modified "2023-10-14" @default.
• W2802666386 title "Multidrug Resistance Protein 1 (MRP1/<i>ABCC1</i>)-Mediated Cellular Protection and Transport of Methylated Arsenic Metabolites Differs between Human Cell Lines" @default.
• W2802666386 cites W117048748 @default.
• W2802666386 cites W1570865673 @default.
• W2802666386 cites W1890023926 @default.
• W2802666386 cites W1964924007 @default.
• W2802666386 cites W1965799368 @default.
• W2802666386 cites W1966452132 @default.
• W2802666386 cites W1966623977 @default.
• W2802666386 cites W1970031380 @default.
• W2802666386 cites W1974802916 @default.
• W2802666386 cites W1980974420 @default.
• W2802666386 cites W1982330330 @default.
• W2802666386 cites W1984580491 @default.
• W2802666386 cites W1992823317 @default.
• W2802666386 cites W1994924349 @default.
• W2802666386 cites W1995564684 @default.
• W2802666386 cites W1997316542 @default.
• W2802666386 cites W1998312178 @default.
• W2802666386 cites W2002523084 @default.
• W2802666386 cites W2009217617 @default.
• W2802666386 cites W2010419238 @default.
• W2802666386 cites W2013131528 @default.
• W2802666386 cites W2013550469 @default.
• W2802666386 cites W2014771666 @default.
• W2802666386 cites W2016524695 @default.
• W2802666386 cites W2019834500 @default.
• W2802666386 cites W2028098070 @default.
• W2802666386 cites W2031009195 @default.
• W2802666386 cites W2031153505 @default.
• W2802666386 cites W2031170601 @default.
• W2802666386 cites W2032306637 @default.
• W2802666386 cites W2035866481 @default.
• W2802666386 cites W2045574831 @default.
• W2802666386 cites W2045978319 @default.
• W2802666386 cites W2053299183 @default.
• W2802666386 cites W2070423872 @default.
• W2802666386 cites W2078572304 @default.
• W2802666386 cites W2079639390 @default.
• W2802666386 cites W2081213990 @default.
• W2802666386 cites W2085332855 @default.
• W2802666386 cites W2086201153 @default.
• W2802666386 cites W2087456641 @default.
• W2802666386 cites W2089037794 @default.
• W2802666386 cites W2097957264 @default.
• W2802666386 cites W2114577256 @default.
• W2802666386 cites W2117349535 @default.
• W2802666386 cites W2120327160 @default.
• W2802666386 cites W2122838293 @default.
• W2802666386 cites W2125529432 @default.
• W2802666386 cites W2135699074 @default.
• W2802666386 cites W2144020356 @default.
• W2802666386 cites W2145835097 @default.
• W2802666386 cites W2169578716 @default.
• W2802666386 cites W2207991208 @default.
• W2802666386 cites W2238774085 @default.
• W2802666386 cites W2321506668 @default.
• W2802666386 cites W2337147024 @default.
• W2802666386 cites W2436697353 @default.
• W2802666386 cites W2470008948 @default.
• W2802666386 cites W2521133475 @default.
• W2802666386 cites W2532179689 @default.
• W2802666386 cites W2543712352 @default.
• W2802666386 cites W2558915591 @default.
• W2802666386 cites W2559589198 @default.
• W2802666386 cites W2573398098 @default.
• W2802666386 doi "https://doi.org/10.1124/dmd.117.079640" @default.
• W2802666386 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29752257" @default.
• W2802666386 hasPublicationYear "2018" @default.
• W2802666386 type Work @default.
• W2802666386 sameAs 2802666386 @default.
• W2802666386 citedByCount "10" @default.
• W2802666386 countsByYear W28026663862019 @default.
• W2802666386 countsByYear W28026663862020 @default.
• W2802666386 countsByYear W28026663862021 @default.
• W2802666386 countsByYear W28026663862022 @default.
• W2802666386 countsByYear W28026663862023 @default.
• W2802666386 crossrefType "journal-article" @default.
• W2802666386 hasAuthorship W2802666386A5005207927 @default.
• W2802666386 hasAuthorship W2802666386A5007283082 @default.
• W2802666386 hasAuthorship W2802666386A5021621511 @default.
• W2802666386 hasAuthorship W2802666386A5042714572 @default.
• W2802666386 hasAuthorship W2802666386A5066932251 @default.
• W2802666386 hasAuthorship W2802666386A5090996417 @default.
• W2802666386 hasBestOaLocation W28026663861 @default.
• W2802666386 hasConcept C104317684 @default.
• W2802666386 hasConcept C130316041 @default.
• W2802666386 hasConcept C1491633281 @default.
• W2802666386 hasConcept C174510640 @default.

• next