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- W2802675021 abstract "The inhibition of pathogenic bacteria at the replication stage is important to halt their further reproduction and spread. The replication enzymes include the DNA gyrase and topoisomerase IV that are recognized targets for the infection control. Novel antibiotic compounds are always in demand for targeting different active sites of these enzymes. Although quinolones are the current drug of choice for targeting these enzymes, emerging resistance is a global concern. Wide-scale efforts are needed to overcome the emerging resistance by designing more potent drugs. In this article, we have reviewed the last five years progress of various classes of non-quinolone-based chemical compounds that are tested for their antibacterial activities." @default.
- W2802675021 created "2018-05-17" @default.
- W2802675021 creator A5044451198 @default.
- W2802675021 creator A5052484053 @default.
- W2802675021 date "2018-05-01" @default.
- W2802675021 modified "2023-09-26" @default.
- W2802675021 title "New developments in non-quinolone-based antibiotics for the inhibiton of bacterial gyrase and topoisomerase IV" @default.
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- W2802675021 doi "https://doi.org/10.1016/j.ejmech.2018.04.059" @default.
- W2802675021 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29751233" @default.
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