Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802693162> ?p ?o ?g. }
- W2802693162 endingPage "910" @default.
- W2802693162 startingPage "899" @default.
- W2802693162 abstract "Alzheimer‘s disease (AD) is the most frequent type of dementia in the elderly, severely affecting functional and executive skills of subjects suffering from this disease. Moreover, the distress of caregivers as well as the social implications constitute a critical issue for families. Furthermore, c ognitive impairment, along with behavioral disorders and neuropsychiatric symptoms are characteristics of AD. Although these are present with variations in prevalence, intensity, and progression, an important core of them is visible before cognitive impairment, especially depression and apathy, which affect at least 50% of patients. The most updated literature shows that depression and/or behavioral and neuropsychiatric symptoms (BNS) are part of the initial phase of the disease rather than just a risk factor. Thus, mood disorders are associated with anomalies in specific brain regions that disturb the normal balance of neurotransmission. This in turn is linked with an inflammatory pathway that leads to microglial activation and aggregated neurofibrillary tangle formation, finally triggering neuronal loss, according to our neuroimmunomodulation theory. Altogether, inflammation and tau aggregation are observed in preclinical stages, preceding the BNS of patients, which in turn are exhibited earlier than cognitive and functional impairment detected in AD. This review is focused on the latest insights of cellular and molecular processes associated with BNS in asymptomatic early-onset stages of AD. An important medical research focus is to improve quality of life of patients, through prevention and treatments of AD, and the study of behavioral disorders and early event in AD pathogenesis has a major impact." @default.
- W2802693162 created "2018-05-17" @default.
- W2802693162 creator A5019832644 @default.
- W2802693162 creator A5024747816 @default.
- W2802693162 creator A5030111650 @default.
- W2802693162 date "2018-05-08" @default.
- W2802693162 modified "2023-09-27" @default.
- W2802693162 title "Behavioral and Neuropsychiatric Disorders in Alzheimer’s Disease" @default.
- W2802693162 cites W1487348428 @default.
- W2802693162 cites W1513815321 @default.
- W2802693162 cites W1542791772 @default.
- W2802693162 cites W159861368 @default.
- W2802693162 cites W1688235741 @default.
- W2802693162 cites W1688672597 @default.
- W2802693162 cites W1785160854 @default.
- W2802693162 cites W1862417723 @default.
- W2802693162 cites W1933444002 @default.
- W2802693162 cites W1964505086 @default.
- W2802693162 cites W1971200109 @default.
- W2802693162 cites W1972276769 @default.
- W2802693162 cites W1972343395 @default.
- W2802693162 cites W1979214750 @default.
- W2802693162 cites W1982694350 @default.
- W2802693162 cites W1983818615 @default.
- W2802693162 cites W1984891266 @default.
- W2802693162 cites W1985582613 @default.
- W2802693162 cites W1985747467 @default.
- W2802693162 cites W1992109356 @default.
- W2802693162 cites W1992720458 @default.
- W2802693162 cites W1994117111 @default.
- W2802693162 cites W1995237297 @default.
- W2802693162 cites W1997031251 @default.
- W2802693162 cites W1998764391 @default.
- W2802693162 cites W2003061822 @default.
- W2802693162 cites W2004385393 @default.
- W2802693162 cites W2004700495 @default.
- W2802693162 cites W2006141992 @default.
- W2802693162 cites W2006777504 @default.
- W2802693162 cites W2013146608 @default.
- W2802693162 cites W2013992160 @default.
- W2802693162 cites W2014196617 @default.
- W2802693162 cites W2021534882 @default.
- W2802693162 cites W2028937444 @default.
- W2802693162 cites W2029821777 @default.
- W2802693162 cites W2033673027 @default.
- W2802693162 cites W2034006349 @default.
- W2802693162 cites W2035121795 @default.
- W2802693162 cites W2036173741 @default.
- W2802693162 cites W2038463584 @default.
- W2802693162 cites W2043297459 @default.
- W2802693162 cites W2046572145 @default.
- W2802693162 cites W2047052426 @default.
- W2802693162 cites W2050265895 @default.
- W2802693162 cites W2051141648 @default.
- W2802693162 cites W2055637478 @default.
- W2802693162 cites W2056341379 @default.
- W2802693162 cites W2058517472 @default.
- W2802693162 cites W2059681878 @default.
- W2802693162 cites W2060446879 @default.
- W2802693162 cites W2071679295 @default.
- W2802693162 cites W2071815275 @default.
- W2802693162 cites W2073023506 @default.
- W2802693162 cites W2078242829 @default.
- W2802693162 cites W2079861976 @default.
- W2802693162 cites W2080844086 @default.
- W2802693162 cites W2082977898 @default.
- W2802693162 cites W2084017889 @default.
- W2802693162 cites W2085558085 @default.
- W2802693162 cites W2085757509 @default.
- W2802693162 cites W2087243986 @default.
- W2802693162 cites W2087557453 @default.
- W2802693162 cites W2088685810 @default.
- W2802693162 cites W2092767820 @default.
- W2802693162 cites W2096890121 @default.
- W2802693162 cites W2105175392 @default.
- W2802693162 cites W2107376426 @default.
- W2802693162 cites W2107962914 @default.
- W2802693162 cites W2108335346 @default.
- W2802693162 cites W2108581121 @default.
- W2802693162 cites W2109984042 @default.
- W2802693162 cites W2110971533 @default.
- W2802693162 cites W2113839148 @default.
- W2802693162 cites W2115017507 @default.
- W2802693162 cites W2115855931 @default.
- W2802693162 cites W2117898751 @default.
- W2802693162 cites W2120296399 @default.
- W2802693162 cites W2120911948 @default.
- W2802693162 cites W2121007598 @default.
- W2802693162 cites W2121365327 @default.
- W2802693162 cites W2121506107 @default.
- W2802693162 cites W2124214624 @default.
- W2802693162 cites W2125018449 @default.
- W2802693162 cites W2125805216 @default.
- W2802693162 cites W2126149232 @default.
- W2802693162 cites W2126269644 @default.
- W2802693162 cites W2126676163 @default.
- W2802693162 cites W2126795224 @default.
- W2802693162 cites W2129497119 @default.