Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802745995> ?p ?o ?g. }
- W2802745995 endingPage "122" @default.
- W2802745995 startingPage "107" @default.
- W2802745995 abstract "Interpolyelectrolyte complexes (IPEC) formulated as multiparticulate drug delivery systems (MDDS) are interesting carriers to improve drug’ performance. Benznidazole (BZ) is the first–line drug for Chagas treatment; however, it presents side effects and toxicity, conditioning its efficacy and safety. The goal of this work was to obtain novel MDDS composed by IPEC based on different polymethacrylate carriers loaded with BZ and to investigate in vitro drug delivery performance for oral administration. Physicochemical characterizations were studied and preclinical studies in a murine model of acute Chagas disease were also performed. The MDDS composed by BZ-loaded IPEC based on polymethacrylates were obtained by casting solvent followed by wet granulation methods with yields >83%. FT-IR demonstrated ionic interaction between the polyelectrolytes. Confocal microscopy, DSC and PXRD revealed a fraction uniformly distributed of free BZ on the multiparticles. The rheological evaluation of the MDDS showed adequate flow features for their formulation in hard gelatin-capsules. The type and composition of IPEC conditioned the modulation of BZ release and fluid uptake results. MDDS based on more hydrophylic Eudragit® showed very fast dissolution (Q15min > 85%), while an extended release (Q120min ≤ 40%) for the hydrophobic ones was observed. Capsules containing a combination of two MDDS with different release profile of BZ showed promising properties to improve Chagas disease pharmacotherapy in the preliminary in vivo assay performed, in which the BZ-loaded MDDS exhibited efficacy to reduce parasitemia, while decreasing the levels of liver injury markers in comparison to BZ conventional treatment. Multi-kinetic BZ delivery systems developed are interesting pharmaceutical alternatives to improve the treatment of Chagas disease." @default.
- W2802745995 created "2018-05-17" @default.
- W2802745995 creator A5015076935 @default.
- W2802745995 creator A5033069942 @default.
- W2802745995 creator A5040489744 @default.
- W2802745995 creator A5041071777 @default.
- W2802745995 creator A5058636905 @default.
- W2802745995 creator A5070505409 @default.
- W2802745995 creator A5077549120 @default.
- W2802745995 date "2018-07-01" @default.
- W2802745995 modified "2023-10-06" @default.
- W2802745995 title "Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes" @default.
- W2802745995 cites W1964307731 @default.
- W2802745995 cites W1964625338 @default.
- W2802745995 cites W1975350613 @default.
- W2802745995 cites W1975615618 @default.
- W2802745995 cites W1976281532 @default.
- W2802745995 cites W1977701255 @default.
- W2802745995 cites W1990729428 @default.
- W2802745995 cites W1992378181 @default.
- W2802745995 cites W1993688446 @default.
- W2802745995 cites W2002633566 @default.
- W2802745995 cites W2004782972 @default.
- W2802745995 cites W2007608479 @default.
- W2802745995 cites W2009738978 @default.
- W2802745995 cites W2015203678 @default.
- W2802745995 cites W2021919058 @default.
- W2802745995 cites W2023391814 @default.
- W2802745995 cites W2024385261 @default.
- W2802745995 cites W2028923684 @default.
- W2802745995 cites W2035808099 @default.
- W2802745995 cites W2036827755 @default.
- W2802745995 cites W2037166940 @default.
- W2802745995 cites W2060320802 @default.
- W2802745995 cites W2060906552 @default.
- W2802745995 cites W2061152402 @default.
- W2802745995 cites W2061977564 @default.
- W2802745995 cites W2065963002 @default.
- W2802745995 cites W2069203749 @default.
- W2802745995 cites W2069470150 @default.
- W2802745995 cites W2074063793 @default.
- W2802745995 cites W2075139947 @default.
- W2802745995 cites W2090639509 @default.
- W2802745995 cites W2091343875 @default.
- W2802745995 cites W2108885771 @default.
- W2802745995 cites W2108951704 @default.
- W2802745995 cites W2115439624 @default.
- W2802745995 cites W2119310721 @default.
- W2802745995 cites W2124679306 @default.
- W2802745995 cites W2128407714 @default.
- W2802745995 cites W2130594273 @default.
- W2802745995 cites W2131397980 @default.
- W2802745995 cites W2132857890 @default.
- W2802745995 cites W2139838474 @default.
- W2802745995 cites W2143489384 @default.
- W2802745995 cites W2153882192 @default.
- W2802745995 cites W2157471870 @default.
- W2802745995 cites W2161234981 @default.
- W2802745995 cites W2165291424 @default.
- W2802745995 cites W2165568633 @default.
- W2802745995 cites W2171492289 @default.
- W2802745995 cites W2202939743 @default.
- W2802745995 cites W2330586706 @default.
- W2802745995 cites W2516478254 @default.
- W2802745995 cites W2588997868 @default.
- W2802745995 cites W2593460139 @default.
- W2802745995 cites W2609323089 @default.
- W2802745995 cites W2737712814 @default.
- W2802745995 cites W4210980497 @default.
- W2802745995 cites W4211070775 @default.
- W2802745995 doi "https://doi.org/10.1016/j.ejps.2018.04.034" @default.
- W2802745995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29705213" @default.
- W2802745995 hasPublicationYear "2018" @default.
- W2802745995 type Work @default.
- W2802745995 sameAs 2802745995 @default.
- W2802745995 citedByCount "17" @default.
- W2802745995 countsByYear W28027459952018 @default.
- W2802745995 countsByYear W28027459952019 @default.
- W2802745995 countsByYear W28027459952020 @default.
- W2802745995 countsByYear W28027459952021 @default.
- W2802745995 countsByYear W28027459952022 @default.
- W2802745995 countsByYear W28027459952023 @default.
- W2802745995 crossrefType "journal-article" @default.
- W2802745995 hasAuthorship W2802745995A5015076935 @default.
- W2802745995 hasAuthorship W2802745995A5033069942 @default.
- W2802745995 hasAuthorship W2802745995A5040489744 @default.
- W2802745995 hasAuthorship W2802745995A5041071777 @default.
- W2802745995 hasAuthorship W2802745995A5058636905 @default.
- W2802745995 hasAuthorship W2802745995A5070505409 @default.
- W2802745995 hasAuthorship W2802745995A5077549120 @default.
- W2802745995 hasBestOaLocation W28027459952 @default.
- W2802745995 hasConcept C136229726 @default.
- W2802745995 hasConcept C136764020 @default.
- W2802745995 hasConcept C14029885 @default.
- W2802745995 hasConcept C150903083 @default.
- W2802745995 hasConcept C159985019 @default.
- W2802745995 hasConcept C171250308 @default.
- W2802745995 hasConcept C185592680 @default.