Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802770655> ?p ?o ?g. }
- W2802770655 endingPage "1667" @default.
- W2802770655 startingPage "1661" @default.
- W2802770655 abstract "Objective: Despite viral suppression, HIV-associated cognitive impairment persists and may be partially due to persistent immune signalling by cells of the myeloid-lineage. Here, we aimed to understand the contribution of activated microglia located in vulnerable brain regions (e.g. frontal, subcortical) of HIV-infected, virally suppressed (HIV+VS) individuals in relation to cognitive and motor function. Design: Twenty-one HIV+VS individuals underwent PET with [11C]DPA-713 to image the translocator protein 18 kDa (TSPO), a marker of microglial activation, and completed a comprehensive neuropsychological test battery. Methods: Multivariable linear regressions were used to examine the contribution of [11C]DPA-713 binding to cognitive performance. Results: Higher [11C]DPA-713 binding was associated with lower cognition among HIV+VS individuals. [11C]DPA-713 binding in middle frontal gyrus/frontal cortex, hippocampus/temporal cortex and occipital cortex was inversely associated with performance on a number of cognitive domains, including verbal memory, processing speed/attention/concentration, executive function, working memory and motor function. [11C]DPA-713 binding in parietal cortex, cerebellum and thalamus was associated with only specific cognitive domains including visual construction and verbal memory. Binding was not associated with global cognitive performance. Conclusion: The findings add to the growing body of evidence that immune-mediated brain injury may contribute to domain specific, HIV-associated, cognitive vulnerabilities despite viral suppression." @default.
- W2802770655 created "2018-05-17" @default.
- W2802770655 creator A5049374899 @default.
- W2802770655 creator A5049568817 @default.
- W2802770655 creator A5068397446 @default.
- W2802770655 creator A5070643861 @default.
- W2802770655 creator A5072809416 @default.
- W2802770655 creator A5081278059 @default.
- W2802770655 creator A5081875954 @default.
- W2802770655 date "2018-07-31" @default.
- W2802770655 modified "2023-10-16" @default.
- W2802770655 title "Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy" @default.
- W2802770655 cites W1774189963 @default.
- W2802770655 cites W1964526292 @default.
- W2802770655 cites W1965597399 @default.
- W2802770655 cites W1974747011 @default.
- W2802770655 cites W1975305176 @default.
- W2802770655 cites W1977530003 @default.
- W2802770655 cites W1981473511 @default.
- W2802770655 cites W1984347355 @default.
- W2802770655 cites W1998332829 @default.
- W2802770655 cites W1999362064 @default.
- W2802770655 cites W2000868000 @default.
- W2802770655 cites W2002199390 @default.
- W2802770655 cites W2007070091 @default.
- W2802770655 cites W2007837046 @default.
- W2802770655 cites W2009833394 @default.
- W2802770655 cites W2014552053 @default.
- W2802770655 cites W2025341113 @default.
- W2802770655 cites W2031648971 @default.
- W2802770655 cites W2031868699 @default.
- W2802770655 cites W2034630499 @default.
- W2802770655 cites W2035112280 @default.
- W2802770655 cites W2039905470 @default.
- W2802770655 cites W2043876312 @default.
- W2802770655 cites W2046371940 @default.
- W2802770655 cites W2047437374 @default.
- W2802770655 cites W2052955118 @default.
- W2802770655 cites W2054735547 @default.
- W2802770655 cites W2069475725 @default.
- W2802770655 cites W2070036973 @default.
- W2802770655 cites W2077541192 @default.
- W2802770655 cites W2079279420 @default.
- W2802770655 cites W2080117718 @default.
- W2802770655 cites W2087423729 @default.
- W2802770655 cites W2091388219 @default.
- W2802770655 cites W2091744820 @default.
- W2802770655 cites W2092013624 @default.
- W2802770655 cites W2099154054 @default.
- W2802770655 cites W2112278807 @default.
- W2802770655 cites W2115118763 @default.
- W2802770655 cites W2122483069 @default.
- W2802770655 cites W2124114936 @default.
- W2802770655 cites W2127267426 @default.
- W2802770655 cites W2138902434 @default.
- W2802770655 cites W2144239158 @default.
- W2802770655 cites W2159936922 @default.
- W2802770655 cites W2161491363 @default.
- W2802770655 cites W2166646981 @default.
- W2802770655 cites W2323859250 @default.
- W2802770655 cites W2325686537 @default.
- W2802770655 cites W2340182575 @default.
- W2802770655 cites W2341083729 @default.
- W2802770655 cites W2351778937 @default.
- W2802770655 cites W2541269035 @default.
- W2802770655 cites W2577286614 @default.
- W2802770655 cites W2581686476 @default.
- W2802770655 cites W2755684038 @default.
- W2802770655 cites W2771127268 @default.
- W2802770655 doi "https://doi.org/10.1097/qad.0000000000001858" @default.
- W2802770655 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6314298" @default.
- W2802770655 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29746297" @default.
- W2802770655 hasPublicationYear "2018" @default.
- W2802770655 type Work @default.
- W2802770655 sameAs 2802770655 @default.
- W2802770655 citedByCount "54" @default.
- W2802770655 countsByYear W28027706552018 @default.
- W2802770655 countsByYear W28027706552019 @default.
- W2802770655 countsByYear W28027706552020 @default.
- W2802770655 countsByYear W28027706552021 @default.
- W2802770655 countsByYear W28027706552022 @default.
- W2802770655 countsByYear W28027706552023 @default.
- W2802770655 crossrefType "journal-article" @default.
- W2802770655 hasAuthorship W2802770655A5049374899 @default.
- W2802770655 hasAuthorship W2802770655A5049568817 @default.
- W2802770655 hasAuthorship W2802770655A5068397446 @default.
- W2802770655 hasAuthorship W2802770655A5070643861 @default.
- W2802770655 hasAuthorship W2802770655A5072809416 @default.
- W2802770655 hasAuthorship W2802770655A5081278059 @default.
- W2802770655 hasAuthorship W2802770655A5081875954 @default.
- W2802770655 hasBestOaLocation W28027706551 @default.
- W2802770655 hasConcept C105641010 @default.
- W2802770655 hasConcept C14216870 @default.
- W2802770655 hasConcept C15744967 @default.
- W2802770655 hasConcept C169760540 @default.
- W2802770655 hasConcept C169900460 @default.
- W2802770655 hasConcept C203014093 @default.
- W2802770655 hasConcept C21963081 @default.