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• W2802797575 abstract "The antileishmanial activity of the essential oil (EO) from Chenopodium ambrosioides L. has been demonstrated in vitro and in animal models, attributed to the major components of the EO. This study focused on the effects of the three major EO compounds carvacrol, caryophyllene oxide (Caryo), and the antileishmanial endoperoxide ascaridole (Asc) on mitochondrial functions in Leishmania tarentolae promastigotes (LtP). EO and Caryo were able to partially inhibit the leishmanial electron transport chain, whereas other components failed to demonstrate a direct immediate effect. Caryo demonstrated inhibition of complex III activity in LtP and in isolated complex III from other species. The formation of superoxide radicals was studied in Leishmania by electron spin resonance spectroscopy in the presence of iron chelators wherein selected compounds failed to trigger a significant immediate additional superoxide production in LtP. However, upon prolonged incubation of Leishmania with Asc and especially in the absence of iron chelators (allowing the activation of Asc), an increased superoxide radical production and significant impairment of mitochondrial coupling in Leishmania was observed. Prolonged incubation with all EO components resulted in thiol depletion. Taken together, the major components of EO mediate their leishmanicidal activity via different mitochondrial targets and time profiles. Further studies are required to elucidate possible synergistic effects of carvacrol and Asc and the influence of minor compounds." @default.
• W2802797575 created "2018-05-17" @default.
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• W2802797575 date "2018-04-19" @default.
• W2802797575 modified "2023-10-15" @default.
• W2802797575 title "Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of<i>Chenopodium ambrosioides</i>L. with mitochondria in<i>Leishmania</i>and other eukaryotes" @default.
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• W2802797575 doi "https://doi.org/10.1002/ptr.6097" @default.
• W2802797575 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6208284" @default.
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