FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802803307> ?p ?o ?g. }

• W2802803307 endingPage "7021" @default.
• W2802803307 startingPage "7009" @default.
• W2802803307 abstract "Abstract Non‐synonymous single nucleotide polymorphisms (nsSNPs) are genetic variations at single base resulting in an amino acid change which have been associated with various complex human diseases. The human Lipoprotein‐associated phospholipase A 2 (Lp‐PLA 2 ) gene harbours a rare Q281R polymorphism which was previously reported to cause loss of enzymatic function. Lp‐PLA 2 is an important enzyme which catalyzes the hydrolysis of polar phospholipids releasing pro‐atherogenic and pro‐inflammatory mediators involved in the pathogenesis of atherosclerosis. Our current study is aimed at elucidating the structural and functional consequences of Q281R polymorphism on Lp‐PLA 2 . The Q281R mutation is classified as deleterious and causes protein instability as deduced from evolutionary, folding free energy changes and Support vector machine (SVM)‐based methods. A Q281R mutant structure was deciphered using homology modelling approach and was validated using phi and psi dihedral angles distribution, ERRAT, Verify_3D scores, Protein Structure Analysis (ProSA) energ,y and Z ‐score. A decreased hydrophobic interactions and weaker substrate binding affinity was observed in the mutant compared to the wild‐ type (WT) using molecular docking. Further, the mutant displayed enhanced structural flexibility particularly in the low density lipoprotein (LDL) binding domain, decreased solvent accessibility of catalytic residues‐Phe274 and Ser273 and increased Cɑ distance between Phe274 and Leu153 and large conformational entropy change as inferred from all‐atom molecular dynamics (MD) simulation and essential dynamics (ED) studies. Our results corroborate well with previous experimental studies and thus these aberrations in the Q281R mutant structure may help explain the molecular basis of loss of enzyme activity." @default.
• W2802803307 created "2018-05-17" @default.
• W2802803307 creator A5016283313 @default.
• W2802803307 creator A5053817882 @default.
• W2802803307 date "2018-05-08" @default.
• W2802803307 modified "2023-09-25" @default.
• W2802803307 title "Impact of a non‐synonymous Q281R polymorphism on structure of human Lipoprotein‐Associated Phospholipase A ₂ (Lp‐PLA ₂ )" @default.
• W2802803307 cites W1563940013 @default.
• W2802803307 cites W1844335036 @default.
• W2802803307 cites W1917431621 @default.
• W2802803307 cites W1966078827 @default.
• W2802803307 cites W1966556984 @default.
• W2802803307 cites W1971938921 @default.
• W2802803307 cites W1986191025 @default.
• W2802803307 cites W1989213989 @default.
• W2802803307 cites W1997079434 @default.
• W2802803307 cites W2001139474 @default.
• W2802803307 cites W2010648593 @default.
• W2802803307 cites W2014095962 @default.
• W2802803307 cites W2015642465 @default.
• W2802803307 cites W2023490488 @default.
• W2802803307 cites W2026460267 @default.
• W2802803307 cites W2029675194 @default.
• W2802803307 cites W2039464415 @default.
• W2802803307 cites W2041476324 @default.
• W2802803307 cites W2046247026 @default.
• W2802803307 cites W2046637512 @default.
• W2802803307 cites W2049007654 @default.
• W2802803307 cites W2049691670 @default.
• W2802803307 cites W2060884615 @default.
• W2802803307 cites W2061008984 @default.
• W2802803307 cites W2069061177 @default.
• W2802803307 cites W2071486470 @default.
• W2802803307 cites W2074473216 @default.
• W2802803307 cites W2080039356 @default.
• W2802803307 cites W2081333842 @default.
• W2802803307 cites W2085771150 @default.
• W2802803307 cites W2100310433 @default.
• W2802803307 cites W2101207877 @default.
• W2802803307 cites W2102284172 @default.
• W2802803307 cites W2105668062 @default.
• W2802803307 cites W2106154817 @default.
• W2802803307 cites W2106882534 @default.
• W2802803307 cites W2107889007 @default.
• W2802803307 cites W2107916366 @default.
• W2802803307 cites W2119217476 @default.
• W2802803307 cites W2119889870 @default.
• W2802803307 cites W2121121770 @default.
• W2802803307 cites W2127981150 @default.
• W2802803307 cites W2132589721 @default.
• W2802803307 cites W2132629607 @default.
• W2802803307 cites W2136513422 @default.
• W2802803307 cites W2144362290 @default.
• W2802803307 cites W2146770020 @default.
• W2802803307 cites W2147421370 @default.
• W2802803307 cites W2148183051 @default.
• W2802803307 cites W2158476854 @default.
• W2802803307 cites W2170549593 @default.
• W2802803307 cites W2551000159 @default.
• W2802803307 cites W2564804443 @default.
• W2802803307 cites W2736063065 @default.
• W2802803307 cites W2737998151 @default.
• W2802803307 cites W2765121078 @default.
• W2802803307 cites W4246356731 @default.
• W2802803307 doi "https://doi.org/10.1002/jcb.26909" @default.
• W2802803307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29737567" @default.
• W2802803307 hasPublicationYear "2018" @default.
• W2802803307 type Work @default.
• W2802803307 sameAs 2802803307 @default.
• W2802803307 citedByCount "3" @default.
• W2802803307 countsByYear W28028033072019 @default.
• W2802803307 countsByYear W28028033072020 @default.
• W2802803307 countsByYear W28028033072022 @default.
• W2802803307 crossrefType "journal-article" @default.
• W2802803307 hasAuthorship W2802803307A5016283313 @default.
• W2802803307 hasAuthorship W2802803307A5053817882 @default.
• W2802803307 hasConcept C104317684 @default.
• W2802803307 hasConcept C143065580 @default.
• W2802803307 hasConcept C147597530 @default.
• W2802803307 hasConcept C159110408 @default.
• W2802803307 hasConcept C169627665 @default.
• W2802803307 hasConcept C181199279 @default.
• W2802803307 hasConcept C185592680 @default.
• W2802803307 hasConcept C195491092 @default.
• W2802803307 hasConcept C2775905019 @default.
• W2802803307 hasConcept C41685203 @default.
• W2802803307 hasConcept C501734568 @default.
• W2802803307 hasConcept C54355233 @default.
• W2802803307 hasConcept C55493867 @default.
• W2802803307 hasConcept C59593255 @default.
• W2802803307 hasConcept C71924100 @default.
• W2802803307 hasConcept C75563809 @default.
• W2802803307 hasConcept C86803240 @default.
• W2802803307 hasConceptScore W2802803307C104317684 @default.
• W2802803307 hasConceptScore W2802803307C143065580 @default.
• W2802803307 hasConceptScore W2802803307C147597530 @default.
• W2802803307 hasConceptScore W2802803307C159110408 @default.
• W2802803307 hasConceptScore W2802803307C169627665 @default.

• next