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- W2802810292 endingPage "1148" @default.
- W2802810292 startingPage "1125" @default.
- W2802810292 abstract "Central nervous system (CNS) injuries, such as stroke, traumatic brain injury (TBI) and spinal cord injury (SCI), are important causes of death and long-term disability worldwide. MicroRNA (miRNA), small non-coding RNA molecules that negatively regulate gene expression, can serve as diagnostic biomarkers and are emerging as novel therapeutic targets for CNS injuries. MiRNA-based therapeutics include miRNA mimics and inhibitors (antagomiRs) to respectively decrease and increase the expression of target genes. In this review, we summarize current miRNA-based therapeutic applications in stroke, TBI and SCI. Administration methods, time windows and dosage for effective delivery of miRNA-based drugs into CNS are discussed. The underlying mechanisms of miRNA-based therapeutics are reviewed including oxidative stress, inflammation, apoptosis, blood–brain barrier protection, angiogenesis and neurogenesis. Pharmacological agents that protect against CNS injuries by targeting specific miRNAs are presented along with the challenges and therapeutic potential of miRNA-based therapies." @default.
- W2802810292 created "2018-05-17" @default.
- W2802810292 creator A5021502220 @default.
- W2802810292 creator A5040002054 @default.
- W2802810292 creator A5070652915 @default.
- W2802810292 creator A5071400420 @default.
- W2802810292 creator A5088465643 @default.
- W2802810292 date "2018-04-30" @default.
- W2802810292 modified "2023-10-03" @default.
- W2802810292 title "MicroRNA-based therapeutics in central nervous system injuries" @default.
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