Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802818971> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2802818971 endingPage "AB110" @default.
- W2802818971 startingPage "AB110" @default.
- W2802818971 abstract ": Oxoglutarate dehydrogenase like (OGDHL) is involved in tricarboxylic acid cycle and was reported as a candidate tumor suppressor in some other tumors. We first explored the mechanisms of OGDHL in human pancreatic ductal adenocarcinoma (PDAC) progression. OGDHL is frequently down-regulated in human PDAC and predicted poor prognosis. OGDHL suppresses PDAC growth though G1 cell cycle arrest both in vivo and in vitro and OGDHL also inhibits migration and invasion ability of PDAC both in vivo and in vitro. Compared with non-tumor tissues, PDAC tissues showed down-regulation of OGDHL and up-regulation of miR-214 and TWIST1. The results showed that OGDHL is a target gene of miR-214 and always negatively regulated by miR-214 and the decrease expression level of OGDHL was on account of the increased expression level of miR-214 in PDAC. In addition, TWIST1 is frequently up-regulated in PDAC and induces miR-214 expression. However OGDHL could inhibit TWIST1 expression via both promoting ubiquitin-mediated proteasomal degradation of HIF1a and regulating AKT pathways. The effect of OGDHL/HIF1a/TWIST1/miR-214 signaling pathway in pancreatic carcinogenesis and metastasis were also determined both in vivo and in vitro. A combination of down-regulation OGDHL and over-expression miR-214 and TWIST1 predicts a poorer overall survival in PDAC patients. Finally, we demonstrated that the relationship of expression among OGDHL, miR-214 and TWIST1 may be a significant predictor of prognosis in PDAC patients. It is a novel pathway in OGDHL-regulated inhibition of PDAC tumorigenesis and metastasis. It may be a brand new targeted therapy in PDAC through OGDHL, TWIST1, miR-214, and HIF1a for prevention, treatment and prognosis." @default.
- W2802818971 created "2018-05-17" @default.
- W2802818971 creator A5019223769 @default.
- W2802818971 creator A5091908162 @default.
- W2802818971 date "2018-04-01" @default.
- W2802818971 modified "2023-10-18" @default.
- W2802818971 title "AB110. P084. OGDHL inhibits human pancreatic ductal adenocarcinoma progression and is regulated by microRNA-214/TWIST1 negative feedback pathway" @default.
- W2802818971 doi "https://doi.org/10.21037/apc.2018.ab110" @default.
- W2802818971 hasPublicationYear "2018" @default.
- W2802818971 type Work @default.
- W2802818971 sameAs 2802818971 @default.
- W2802818971 citedByCount "0" @default.
- W2802818971 crossrefType "journal-article" @default.
- W2802818971 hasAuthorship W2802818971A5019223769 @default.
- W2802818971 hasAuthorship W2802818971A5091908162 @default.
- W2802818971 hasConcept C104317684 @default.
- W2802818971 hasConcept C121608353 @default.
- W2802818971 hasConcept C126322002 @default.
- W2802818971 hasConcept C127561419 @default.
- W2802818971 hasConcept C145059251 @default.
- W2802818971 hasConcept C150903083 @default.
- W2802818971 hasConcept C190283241 @default.
- W2802818971 hasConcept C207001950 @default.
- W2802818971 hasConcept C2779013556 @default.
- W2802818971 hasConcept C2780394083 @default.
- W2802818971 hasConcept C29537977 @default.
- W2802818971 hasConcept C31194975 @default.
- W2802818971 hasConcept C502942594 @default.
- W2802818971 hasConcept C55493867 @default.
- W2802818971 hasConcept C555283112 @default.
- W2802818971 hasConcept C62478195 @default.
- W2802818971 hasConcept C71924100 @default.
- W2802818971 hasConcept C75217442 @default.
- W2802818971 hasConcept C86554907 @default.
- W2802818971 hasConcept C86803240 @default.
- W2802818971 hasConcept C95444343 @default.
- W2802818971 hasConceptScore W2802818971C104317684 @default.
- W2802818971 hasConceptScore W2802818971C121608353 @default.
- W2802818971 hasConceptScore W2802818971C126322002 @default.
- W2802818971 hasConceptScore W2802818971C127561419 @default.
- W2802818971 hasConceptScore W2802818971C145059251 @default.
- W2802818971 hasConceptScore W2802818971C150903083 @default.
- W2802818971 hasConceptScore W2802818971C190283241 @default.
- W2802818971 hasConceptScore W2802818971C207001950 @default.
- W2802818971 hasConceptScore W2802818971C2779013556 @default.
- W2802818971 hasConceptScore W2802818971C2780394083 @default.
- W2802818971 hasConceptScore W2802818971C29537977 @default.
- W2802818971 hasConceptScore W2802818971C31194975 @default.
- W2802818971 hasConceptScore W2802818971C502942594 @default.
- W2802818971 hasConceptScore W2802818971C55493867 @default.
- W2802818971 hasConceptScore W2802818971C555283112 @default.
- W2802818971 hasConceptScore W2802818971C62478195 @default.
- W2802818971 hasConceptScore W2802818971C71924100 @default.
- W2802818971 hasConceptScore W2802818971C75217442 @default.
- W2802818971 hasConceptScore W2802818971C86554907 @default.
- W2802818971 hasConceptScore W2802818971C86803240 @default.
- W2802818971 hasConceptScore W2802818971C95444343 @default.
- W2802818971 hasIssue "1" @default.
- W2802818971 hasLocation W28028189711 @default.
- W2802818971 hasOpenAccess W2802818971 @default.
- W2802818971 hasPrimaryLocation W28028189711 @default.
- W2802818971 hasRelatedWork W1557020267 @default.
- W2802818971 hasRelatedWork W1988747615 @default.
- W2802818971 hasRelatedWork W2044529491 @default.
- W2802818971 hasRelatedWork W2170163263 @default.
- W2802818971 hasRelatedWork W2901382528 @default.
- W2802818971 hasRelatedWork W2944880966 @default.
- W2802818971 hasRelatedWork W2981184832 @default.
- W2802818971 hasRelatedWork W3032012141 @default.
- W2802818971 hasRelatedWork W3086552618 @default.
- W2802818971 hasRelatedWork W4281708914 @default.
- W2802818971 hasVolume "1" @default.
- W2802818971 isParatext "false" @default.
- W2802818971 isRetracted "false" @default.
- W2802818971 magId "2802818971" @default.
- W2802818971 workType "article" @default.