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• W2802823318 abstract "Background Clinical trials have shown very modest short-term improvements in glycemic control among participants with diabetes after periodontitis treatment. Few longitudinal studies suggest that periodontitis may be related to prediabetes/diabetes risk. Methods We evaluated 1206 diabetes free participants in the San Juan Overweight Adults Longitudinal Study (SOALS) and 941 with complete 3-year follow-up data were included. The National Health and Nutrition Examination Survey (NHANES) methods were used to assess periodontitis. Diabetes and prediabetes were classified using American Diabetes Association cutoffs for fasting and 2-hour post-load glucose and HbA1c. We used Poisson regression adjusting for baseline age, gender, smoking, education, family history of diabetes, physical activity, waist circumference, and alcohol intake. Results Over the 3-year follow-up, 69 (7.3%) of the 941 individuals developed type 2 diabetes, and 142 (34.9%) of the 407 with normal glycemia at baseline developed prediabetes. In multivariable models, greater mean pocket depth and mean attachment loss at baseline were associated with lower risk of developing prediabetes/diabetes over the follow-up (IRR = 0.81; 95% CI: 0.67–0.99, and IRR = 0.86; 95% CI: 0.74–0.99, respectively). Increase in periodontal attachment loss from baseline to follow-up was associated with higher prediabetes/diabetes risk (multivariate IRR = 1.25; 95% CI: 1.09–1.42), and increase in pocket depth was associated with >20% fasting glucose increase (multivariate IRR = 1.43; 95% CI: 1.14–1.79). The inverse associations persisted after additionally adjusting for baseline income, sugar-sweetened beverages, number of teeth, oral hygiene, glycemia, or previous periodontal therapy. Conclusions There is no association between periodontitis and risk of prediabetes/diabetes in this longitudinal study." @default.
• W2802823318 created "2018-05-17" @default.
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• W2802823318 date "2018-07-01" @default.
• W2802823318 modified "2023-10-17" @default.
• W2802823318 title "Longitudinal association between periodontitis and development of diabetes" @default.
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• W2802823318 doi "https://doi.org/10.1016/j.diabres.2018.04.028" @default.
• W2802823318 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6016543" @default.
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