Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802833332> ?p ?o ?g. }
- W2802833332 endingPage "243" @default.
- W2802833332 startingPage "243" @default.
- W2802833332 abstract "Mitochondrial respiratory function is now recognized as a pivotal player in all the aspects of cancer biology, from tumorigenesis to aggressiveness and chemotherapy resistance. Among the enzymes that compose the respiratory chain, by contributing to energy production, redox equilibrium and oxidative stress, complex I assumes a central role. Complex I defects may arise from mutations in mitochondrial or nuclear DNA, in both structural genes or assembly factors, from alteration of the expression levels of its subunits, or from drug exposure. Since cancer cells have a high-energy demand and require macromolecules for proliferation, it is not surprising that severe complex I defects, caused either by mutations or treatment with specific inhibitors, prevent tumor progression, while contributing to resistance to certain chemotherapeutic agents. On the other hand, enhanced oxidative stress due to mild complex I dysfunction drives an opposite phenotype, as it stimulates cancer cell proliferation and invasiveness. We here review the current knowledge on the contribution of respiratory complex I to cancer biology, highlighting the double-edged role of this metabolic enzyme in tumor progression, metastasis formation, and response to chemotherapy." @default.
- W2802833332 created "2018-05-17" @default.
- W2802833332 creator A5009635225 @default.
- W2802833332 creator A5020752451 @default.
- W2802833332 creator A5030285343 @default.
- W2802833332 creator A5042045502 @default.
- W2802833332 creator A5056609149 @default.
- W2802833332 date "2018-05-07" @default.
- W2802833332 modified "2023-10-15" @default.
- W2802833332 title "The Oncojanus Paradigm of Respiratory Complex I" @default.
- W2802833332 cites W1018604741 @default.
- W2802833332 cites W1509720837 @default.
- W2802833332 cites W1802480460 @default.
- W2802833332 cites W1968408636 @default.
- W2802833332 cites W1968564300 @default.
- W2802833332 cites W1970421103 @default.
- W2802833332 cites W1975368902 @default.
- W2802833332 cites W1977090078 @default.
- W2802833332 cites W1977613875 @default.
- W2802833332 cites W1979246886 @default.
- W2802833332 cites W1979484027 @default.
- W2802833332 cites W1979575103 @default.
- W2802833332 cites W1980339513 @default.
- W2802833332 cites W1980783433 @default.
- W2802833332 cites W1988827270 @default.
- W2802833332 cites W1993095088 @default.
- W2802833332 cites W1993599898 @default.
- W2802833332 cites W1999059713 @default.
- W2802833332 cites W1999436768 @default.
- W2802833332 cites W1999532628 @default.
- W2802833332 cites W2002394990 @default.
- W2802833332 cites W2007891991 @default.
- W2802833332 cites W2012442151 @default.
- W2802833332 cites W2014692100 @default.
- W2802833332 cites W2026967508 @default.
- W2802833332 cites W2027184535 @default.
- W2802833332 cites W2028544780 @default.
- W2802833332 cites W2030637794 @default.
- W2802833332 cites W2037333488 @default.
- W2802833332 cites W2040845628 @default.
- W2802833332 cites W2046366602 @default.
- W2802833332 cites W2046566818 @default.
- W2802833332 cites W2048366336 @default.
- W2802833332 cites W2048965827 @default.
- W2802833332 cites W2049641602 @default.
- W2802833332 cites W2051213562 @default.
- W2802833332 cites W2053604149 @default.
- W2802833332 cites W2058525868 @default.
- W2802833332 cites W2067244501 @default.
- W2802833332 cites W2070002948 @default.
- W2802833332 cites W2070143299 @default.
- W2802833332 cites W2072573480 @default.
- W2802833332 cites W2074847845 @default.
- W2802833332 cites W2076908467 @default.
- W2802833332 cites W2076971346 @default.
- W2802833332 cites W2079096821 @default.
- W2802833332 cites W2084210172 @default.
- W2802833332 cites W2084272937 @default.
- W2802833332 cites W2084621494 @default.
- W2802833332 cites W2089461431 @default.
- W2802833332 cites W2098273451 @default.
- W2802833332 cites W2099068165 @default.
- W2802833332 cites W2106406160 @default.
- W2802833332 cites W2109993967 @default.
- W2802833332 cites W2116196939 @default.
- W2802833332 cites W2117393645 @default.
- W2802833332 cites W2117446661 @default.
- W2802833332 cites W2117650276 @default.
- W2802833332 cites W2119437574 @default.
- W2802833332 cites W2119978648 @default.
- W2802833332 cites W2124172718 @default.
- W2802833332 cites W2124276356 @default.
- W2802833332 cites W2129422215 @default.
- W2802833332 cites W2129900098 @default.
- W2802833332 cites W2133512940 @default.
- W2802833332 cites W2138004837 @default.
- W2802833332 cites W2138800150 @default.
- W2802833332 cites W2139732486 @default.
- W2802833332 cites W2140164776 @default.
- W2802833332 cites W2141778626 @default.
- W2802833332 cites W2141847223 @default.
- W2802833332 cites W2145795805 @default.
- W2802833332 cites W2146119807 @default.
- W2802833332 cites W2148332345 @default.
- W2802833332 cites W2151568543 @default.
- W2802833332 cites W2156370651 @default.
- W2802833332 cites W2156603613 @default.
- W2802833332 cites W2158666748 @default.
- W2802833332 cites W2161036732 @default.
- W2802833332 cites W2167284343 @default.
- W2802833332 cites W2167438676 @default.
- W2802833332 cites W2195022070 @default.
- W2802833332 cites W2198724960 @default.
- W2802833332 cites W2278896297 @default.
- W2802833332 cites W2313668997 @default.
- W2802833332 cites W2333034303 @default.
- W2802833332 cites W2356675978 @default.
- W2802833332 cites W2470619195 @default.