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- W2802833806 abstract "Psoriasis is a Th17-mediated chronic inflammatory skin disease with aberrant keratinocyte proliferation and differentiation. Th17 cytokines like IL-17, IL-22 and IL-23 are critically involved in psoriasis pathogenesis that results in epidermal thickening and production of innate factors such as antimicrobial peptides. Topical treatment of psoriasis with anthralin is highly effective although the exact mode of action of this drug in psoriasis is not fully understood. We aimed to study the direct effects of anthralin on keratinocyte proliferation, differentiation and production of innate factors like antimicrobial factors. To test the effects of anthralin we used (1) primary keratinocytes, (2) a 3D psoriasis tissue models and (3) skin biopsies from patients treated with anthralin. In addition we studied the effects of anthralin in monolayer and multilayer keratinocyte cultures stimulated with IL-17A and IL-22. Anthralin directly induced cell apoptosis in vitro in monolayer cultures but not in multilayer cultures treated with IL-17A and IL-22. Yet, keratinocyte proliferation was impaired by anthralin in vitro and in vivo. In lesional skin anthralin rapidly normalized cytokeratin (CK)16 expression. Moreover, anthralin suppressed DEFB4 expression in vitro and in vivo, while other antimicrobial peptides and innate cytokines studied like IL-6 and IL-8 were regulated differently in vitro and in vivo. Taken together anthralin has direct effects on keratinocytes beyond the impairment of proliferation. CK16 and DEFB4 expression by keratinocytes were both suppressed by anthralin." @default.
- W2802833806 created "2018-05-17" @default.
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- W2802833806 date "2018-05-01" @default.
- W2802833806 modified "2023-09-30" @default.
- W2802833806 title "721 Effects of anthralin on innate factors and cytokeratins expression by keratinocytes" @default.
- W2802833806 doi "https://doi.org/10.1016/j.jid.2018.03.730" @default.
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