Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802858497> ?p ?o ?g. }
- W2802858497 abstract "Abstract Cells sense biochemical as well as mechanical signals from their microenvironment by engaging multiple receptors. In many cases, multiple receptors operate in concert, and it can be misleading to attempt to isolate a single ligand–receptor interaction. Supported lipid membranes are employed to reconstitute a number of cell receptor systems. Efforts are also made to fabricate membrane microarrays presenting multiple ligands in a spatially segregated manner. However, such membrane multiplexing methods are generally limited by complex instrumentation and scalability. Here, a straightforward method is presented to produce centimeter‐scale membrane microarrays displaying multiple, spatially segregated membrane‐anchored protein ligands suitable for live single‐cell studies. The method is based on stochastic membrane fusion and subsequent diffusion‐mediated mixing of their lipid content. The result is the delivery of membrane contents into spatially segregated membrane corrals. Utilizing the technology developed here, this work probes the recruitment of an adaptor protein, Shc1, to epidermal growth factor receptor (EGFR) and EphA2 receptors and shows that activation of EGFR results in a decrease in the recruitment of protein to activate EphA2 same cell." @default.
- W2802858497 created "2018-05-17" @default.
- W2802858497 creator A5011860224 @default.
- W2802858497 creator A5029421861 @default.
- W2802858497 creator A5048573382 @default.
- W2802858497 creator A5050023964 @default.
- W2802858497 creator A5074770283 @default.
- W2802858497 date "2018-02-21" @default.
- W2802858497 modified "2023-10-16" @default.
- W2802858497 title "Multicomponent Supported Membrane Microarray for Monitoring Spatially Resolved Cellular Signaling Reactions" @default.
- W2802858497 cites W1523736896 @default.
- W2802858497 cites W1935095490 @default.
- W2802858497 cites W1964059200 @default.
- W2802858497 cites W1964823826 @default.
- W2802858497 cites W1967359088 @default.
- W2802858497 cites W1967700127 @default.
- W2802858497 cites W1971072048 @default.
- W2802858497 cites W1978532747 @default.
- W2802858497 cites W1979984478 @default.
- W2802858497 cites W1980552211 @default.
- W2802858497 cites W1982916327 @default.
- W2802858497 cites W1983284964 @default.
- W2802858497 cites W1987428905 @default.
- W2802858497 cites W1994603958 @default.
- W2802858497 cites W2002974485 @default.
- W2802858497 cites W2003673415 @default.
- W2802858497 cites W2004391994 @default.
- W2802858497 cites W2006697461 @default.
- W2802858497 cites W2007564617 @default.
- W2802858497 cites W2010030578 @default.
- W2802858497 cites W2010500827 @default.
- W2802858497 cites W2011177376 @default.
- W2802858497 cites W2015208531 @default.
- W2802858497 cites W2017934591 @default.
- W2802858497 cites W2020997565 @default.
- W2802858497 cites W2023542261 @default.
- W2802858497 cites W2023957622 @default.
- W2802858497 cites W2028682200 @default.
- W2802858497 cites W2033599085 @default.
- W2802858497 cites W2040665000 @default.
- W2802858497 cites W2041653006 @default.
- W2802858497 cites W2043601243 @default.
- W2802858497 cites W2046425140 @default.
- W2802858497 cites W2048191546 @default.
- W2802858497 cites W2048924360 @default.
- W2802858497 cites W2051161717 @default.
- W2802858497 cites W2051266336 @default.
- W2802858497 cites W2056681493 @default.
- W2802858497 cites W2056731520 @default.
- W2802858497 cites W2057251045 @default.
- W2802858497 cites W2060070314 @default.
- W2802858497 cites W2062490405 @default.
- W2802858497 cites W2064443354 @default.
- W2802858497 cites W2068250776 @default.
- W2802858497 cites W2073236468 @default.
- W2802858497 cites W2074787672 @default.
- W2802858497 cites W2078387056 @default.
- W2802858497 cites W2079018735 @default.
- W2802858497 cites W2093486460 @default.
- W2802858497 cites W2096234619 @default.
- W2802858497 cites W2100890166 @default.
- W2802858497 cites W2106510334 @default.
- W2802858497 cites W2127639138 @default.
- W2802858497 cites W2142298838 @default.
- W2802858497 cites W2146503939 @default.
- W2802858497 cites W2148294117 @default.
- W2802858497 cites W2153231341 @default.
- W2802858497 cites W2162504167 @default.
- W2802858497 cites W2167279371 @default.
- W2802858497 cites W2168167465 @default.
- W2802858497 cites W2258336271 @default.
- W2802858497 cites W2313889988 @default.
- W2802858497 cites W2323289371 @default.
- W2802858497 cites W2327287238 @default.
- W2802858497 cites W2414575046 @default.
- W2802858497 cites W2471075308 @default.
- W2802858497 cites W2473392275 @default.
- W2802858497 cites W2512061829 @default.
- W2802858497 cites W2526887159 @default.
- W2802858497 cites W2564032466 @default.
- W2802858497 cites W2592133876 @default.
- W2802858497 cites W2592666036 @default.
- W2802858497 cites W2602990311 @default.
- W2802858497 cites W2613271410 @default.
- W2802858497 doi "https://doi.org/10.1002/adbi.201800015" @default.
- W2802858497 hasPublicationYear "2018" @default.
- W2802858497 type Work @default.
- W2802858497 sameAs 2802858497 @default.
- W2802858497 citedByCount "14" @default.
- W2802858497 countsByYear W28028584972018 @default.
- W2802858497 countsByYear W28028584972019 @default.
- W2802858497 countsByYear W28028584972020 @default.
- W2802858497 countsByYear W28028584972021 @default.
- W2802858497 countsByYear W28028584972022 @default.
- W2802858497 countsByYear W28028584972023 @default.
- W2802858497 crossrefType "journal-article" @default.
- W2802858497 hasAuthorship W2802858497A5011860224 @default.
- W2802858497 hasAuthorship W2802858497A5029421861 @default.
- W2802858497 hasAuthorship W2802858497A5048573382 @default.
- W2802858497 hasAuthorship W2802858497A5050023964 @default.