FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802874902> ?p ?o ?g. }

• W2802874902 endingPage "142" @default.
• W2802874902 startingPage "133" @default.
• W2802874902 abstract "<b><i>Background:</i></b> Previous murine models have demonstrated interleukin (IL)-33 to be an important mediator of type-2 inflammation and to promote airway hyperresponsiveness in allergic asthma. A number of inflammatory cells produce IL-33 and eosinophils express ST2 mRNA. The relationship between IL-33 and eosinophils in allergic asthma, however, remains unclear. <b><i>Objective:</i></b> The aim of this work was to evaluate in vitro the effect of allergen inhalation on IL-33 levels and expression of its receptor (ST2L) on eosinophils in allergic asthmatics, and the effect of IL-33 stimulation on eosinophil activity. <b><i>Methods:</i></b> Plasma and sputum IL-33, soluble ST2 (sST2) levels, and ST2L expression on eosinophils were measured in 10 healthy controls and 10 allergic asthmatics. Asthmatics underwent allergen and diluent inhalation challenges. Blood and sputum samples were collected to measure IL-33, sST2, and ST2L eosinophil expression before and 24 h after allergen inhalation. Purified blood eosinophils from allergic asthmatics were incubated overnight with IL-33 to assess ST2 and intracellular IL-5 expression. <b><i>Results:</i></b> Baseline levels of IL-33 in sputum and sST2 in plasma and sputum were similar in allergic asthmatics compared to healthy controls. In addition, there was no difference in blood or sputum eosinophil ST2L expression in healthy controls versus allergic asthmatics. Eosinophil ST2L expression was significantly increased 24 h postallergen inhalation in allergic asthmatics. In vitro stimulation of human eosinophils with IL-33 and LPS significantly increased eosinophil ST2L expression and IL-33 stimulation increased intracellular IL-5 expression, which was attenuated by treatment with sST2 and ST2 blockade. <b><i>Conclusion and Clinical Relevance:</i></b> In mild asthmatics, there was a significant upregulation of ST2 surface expression on eosinophils from blood and sputum following allergen inhalation challenge. In vitro, IL-33 stimulation of eosinophils increases both ST2 membrane expression and IL-5 production. These results support a role for IL-33 in causing allergen-induced eosinophilia. Blockade of IL-33 and ST2 signaling may present a novel therapeutic avenue for asthma treatment." @default.
• W2802874902 created "2018-05-17" @default.
• W2802874902 creator A5016053143 @default.
• W2802874902 creator A5018374796 @default.
• W2802874902 creator A5031238472 @default.
• W2802874902 creator A5041588741 @default.
• W2802874902 creator A5051271540 @default.
• W2802874902 creator A5054400260 @default.
• W2802874902 creator A5054694447 @default.
• W2802874902 creator A5090494500 @default.
• W2802874902 creator A5091014823 @default.
• W2802874902 date "2018-01-01" @default.
• W2802874902 modified "2023-10-05" @default.
• W2802874902 title "IL-33 and Its Receptor ST2 after Inhaled Allergen Challenge in Allergic Asthmatics" @default.
• W2802874902 cites W1575966267 @default.
• W2802874902 cites W1966991400 @default.
• W2802874902 cites W1968070392 @default.
• W2802874902 cites W1968955229 @default.
• W2802874902 cites W1978530217 @default.
• W2802874902 cites W1986997649 @default.
• W2802874902 cites W2002892444 @default.
• W2802874902 cites W2004490702 @default.
• W2802874902 cites W2011492566 @default.
• W2802874902 cites W2019152390 @default.
• W2802874902 cites W2019546252 @default.
• W2802874902 cites W2028835231 @default.
• W2802874902 cites W2032405768 @default.
• W2802874902 cites W2034634678 @default.
• W2802874902 cites W2036982614 @default.
• W2802874902 cites W2038751520 @default.
• W2802874902 cites W2046017757 @default.
• W2802874902 cites W2050267061 @default.
• W2802874902 cites W2057438669 @default.
• W2802874902 cites W2057574652 @default.
• W2802874902 cites W2061415821 @default.
• W2802874902 cites W2069609111 @default.
• W2802874902 cites W2073856262 @default.
• W2802874902 cites W2079778462 @default.
• W2802874902 cites W2080725704 @default.
• W2802874902 cites W2081660494 @default.
• W2802874902 cites W2109215307 @default.
• W2802874902 cites W2137520462 @default.
• W2802874902 cites W2140083164 @default.
• W2802874902 cites W2148198599 @default.
• W2802874902 cites W2149011057 @default.
• W2802874902 cites W2150594596 @default.
• W2802874902 cites W2154263136 @default.
• W2802874902 cites W2155432151 @default.
• W2802874902 cites W2159210177 @default.
• W2802874902 cites W2163283525 @default.
• W2802874902 cites W2165235005 @default.
• W2802874902 cites W2167033981 @default.
• W2802874902 cites W2167913542 @default.
• W2802874902 cites W2232841693 @default.
• W2802874902 cites W2271642981 @default.
• W2802874902 doi "https://doi.org/10.1159/000488015" @default.
• W2802874902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29694974" @default.
• W2802874902 hasPublicationYear "2018" @default.
• W2802874902 type Work @default.
• W2802874902 sameAs 2802874902 @default.
• W2802874902 citedByCount "32" @default.
• W2802874902 countsByYear W28028749022018 @default.
• W2802874902 countsByYear W28028749022019 @default.
• W2802874902 countsByYear W28028749022020 @default.
• W2802874902 countsByYear W28028749022021 @default.
• W2802874902 countsByYear W28028749022022 @default.
• W2802874902 countsByYear W28028749022023 @default.
• W2802874902 crossrefType "journal-article" @default.
• W2802874902 hasAuthorship W2802874902A5016053143 @default.
• W2802874902 hasAuthorship W2802874902A5018374796 @default.
• W2802874902 hasAuthorship W2802874902A5031238472 @default.
• W2802874902 hasAuthorship W2802874902A5041588741 @default.
• W2802874902 hasAuthorship W2802874902A5051271540 @default.
• W2802874902 hasAuthorship W2802874902A5054400260 @default.
• W2802874902 hasAuthorship W2802874902A5054694447 @default.
• W2802874902 hasAuthorship W2802874902A5090494500 @default.
• W2802874902 hasAuthorship W2802874902A5091014823 @default.
• W2802874902 hasConcept C105702510 @default.
• W2802874902 hasConcept C126322002 @default.
• W2802874902 hasConcept C142724271 @default.
• W2802874902 hasConcept C170493617 @default.
• W2802874902 hasConcept C181901479 @default.
• W2802874902 hasConcept C203014093 @default.
• W2802874902 hasConcept C207480886 @default.
• W2802874902 hasConcept C2776042228 @default.
• W2802874902 hasConcept C2776301714 @default.
• W2802874902 hasConcept C2776954882 @default.
• W2802874902 hasConcept C2777037409 @default.
• W2802874902 hasConcept C2778690821 @default.
• W2802874902 hasConcept C2779675166 @default.
• W2802874902 hasConcept C2780510475 @default.
• W2802874902 hasConcept C2781069245 @default.
• W2802874902 hasConcept C71924100 @default.
• W2802874902 hasConcept C74172505 @default.
• W2802874902 hasConcept C88675164 @default.
• W2802874902 hasConceptScore W2802874902C105702510 @default.
• W2802874902 hasConceptScore W2802874902C126322002 @default.
• W2802874902 hasConceptScore W2802874902C142724271 @default.

• next