FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802902972> ?p ?o ?g. }

• W2802902972 endingPage "106" @default.
• W2802902972 startingPage "102" @default.
• W2802902972 abstract "Background. As you know, severe traumatic brain injury is accompanied by the development of hypoxia with the subsequent death of nerve cells. The autoimmune reactions of the cellular and humoral type play an important role in the pathological process. The purpose of the work was to study the content of autoantibodies to brain antigens in the blood of patients with severe traumatic brain injury. Materials and me­thods. 40 patients with isolated severe traumatic brain injury were examined in the postoperative period. The control group consisted of 20 healthy volunteers. The content of autoantibodies to brain antigens (myelin basic protein (MBP), S-100 protein, neurospecific enolase (NSE) and heterophile brain antigen) was determined by the method of enzyme-linked immunosorbent assay оn days 1, 3, 5, 7, 14 after operative intervention. Results. It was found that the level of autoantibodies to the MBP on day 1, as well as throughout the study, did not significantly differ from that of healthy volunteers. The concentration of autoantibodies to protein S-100 on day 1 was not significantly different from that of healthy volunteers, but on day 3 it increased, the difference between patients and healthy volunteers was statistically significant. On day 5, there was a decrease in the indicators with a significant difference. On days 7 and 14, the levels of autoantibodies in patients gradually decreased (p > 0.05). The level of autoantibodies to the neuronspecific enolase on day 1 did not exceed the values of healthy volunteers (p > 0.05). On day 3, the level increased reaching the peak on day 5, when the difference in comparison with healthy volunteers was statistically significant. In future, there was a decrease in the indicators with the preservation of statistical reliability. The levels of autoantibodies to the hete­rophile brain antigen on day 1 were elevated, but did not significantly differ from those of healthy volunteers. Subsequently, the figures increased reaching a peak on day 5, when they statistically varied from healthy volunteers. Afterwards, there was a decrease in the indicators on days 7 and 14, with a statistically significant difference remaining. Conclusions. The results of our study showed that severe traumatic brain injury causes elevated levels of specific autoantibodies to brain antigens in the blood serum of patients. A high level of autoantibodies to neurospecific enolase, protein S-100, heterophile brain antigen, and a low level to the myelin basic protein have been recorded. This allows us to conclude that neurons and astroglia are prone primarily to changes and damage, since an autoimmune process is activated to their antigens." @default.
• W2802902972 created "2018-05-17" @default.
• W2802902972 creator A5059797153 @default.
• W2802902972 date "2018-02-06" @default.
• W2802902972 modified "2023-09-25" @default.
• W2802902972 title "Dynamics of levels of neuroautoantibodies in the blood of patients with severe traumatic brain injury" @default.
• W2802902972 doi "https://doi.org/10.22141/2224-0586.8.87.2017.121332" @default.
• W2802902972 hasPublicationYear "2018" @default.
• W2802902972 type Work @default.
• W2802902972 sameAs 2802902972 @default.
• W2802902972 citedByCount "0" @default.
• W2802902972 crossrefType "journal-article" @default.
• W2802902972 hasAuthorship W2802902972A5059797153 @default.
• W2802902972 hasBestOaLocation W28029029721 @default.
• W2802902972 hasConcept C118552586 @default.
• W2802902972 hasConcept C126322002 @default.
• W2802902972 hasConcept C147483822 @default.
• W2802902972 hasConcept C159654299 @default.
• W2802902972 hasConcept C163764329 @default.
• W2802902972 hasConcept C188618488 @default.
• W2802902972 hasConcept C203014093 @default.
• W2802902972 hasConcept C204232928 @default.
• W2802902972 hasConcept C207886595 @default.
• W2802902972 hasConcept C2778609137 @default.
• W2802902972 hasConcept C2780876595 @default.
• W2802902972 hasConcept C2781017439 @default.
• W2802902972 hasConcept C529278444 @default.
• W2802902972 hasConcept C71924100 @default.
• W2802902972 hasConcept C90924648 @default.
• W2802902972 hasConceptScore W2802902972C118552586 @default.
• W2802902972 hasConceptScore W2802902972C126322002 @default.
• W2802902972 hasConceptScore W2802902972C147483822 @default.
• W2802902972 hasConceptScore W2802902972C159654299 @default.
• W2802902972 hasConceptScore W2802902972C163764329 @default.
• W2802902972 hasConceptScore W2802902972C188618488 @default.
• W2802902972 hasConceptScore W2802902972C203014093 @default.
• W2802902972 hasConceptScore W2802902972C204232928 @default.
• W2802902972 hasConceptScore W2802902972C207886595 @default.
• W2802902972 hasConceptScore W2802902972C2778609137 @default.
• W2802902972 hasConceptScore W2802902972C2780876595 @default.
• W2802902972 hasConceptScore W2802902972C2781017439 @default.
• W2802902972 hasConceptScore W2802902972C529278444 @default.
• W2802902972 hasConceptScore W2802902972C71924100 @default.
• W2802902972 hasConceptScore W2802902972C90924648 @default.
• W2802902972 hasIssue "8.87" @default.
• W2802902972 hasLocation W28029029721 @default.
• W2802902972 hasOpenAccess W2802902972 @default.
• W2802902972 hasPrimaryLocation W28029029721 @default.
• W2802902972 hasRelatedWork W1972092068 @default.
• W2802902972 hasRelatedWork W1977810547 @default.
• W2802902972 hasRelatedWork W2117732017 @default.
• W2802902972 hasRelatedWork W2146971406 @default.
• W2802902972 hasRelatedWork W2171078400 @default.
• W2802902972 hasRelatedWork W2390914893 @default.
• W2802902972 hasRelatedWork W2734587042 @default.
• W2802902972 hasRelatedWork W279517719 @default.
• W2802902972 hasRelatedWork W3042636889 @default.
• W2802902972 hasRelatedWork W2182119931 @default.
• W2802902972 hasVolume "0" @default.
• W2802902972 isParatext "false" @default.
• W2802902972 isRetracted "false" @default.
• W2802902972 magId "2802902972" @default.
• W2802902972 workType "article" @default.