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- W2802907135 abstract "Stem cells have the capacity to undergo self-renewal and also to give rise to differentiated cells upon receiving appropriate developmental cues. The action of stem cells is crucial for proper embryonic development in vivo, and even in adult life, endogenous adult stem cells are central players in tissue homeostasis and organ renewal. Not surprisingly, insults to pluripotent and multipotent stem cells of the embryo and fetus can result in birth defects. More subtle impacts upon resident adult stem and progenitor cells can cause degenerative disorders of many organs, to include neurological deficits. Embryonic stem cells (ESCs) are derived from the inner cell mass of blastocyst-stage embryos, and induced pluripotent stem cells (iPSCs) can be produced by the artificial reprogramming of terminally differentiated cells. ESCs and iPSCs have been used to develop in vitro platforms to investigate teratogen action and also serve as models for human developmental and degenerative disorders. This chapter provides an overview of basic features of pluripotent and adult stem cells and their use for human teratological studies and disease modeling and finally, discusses emerging trends in pluripotent stem cell research for teratology and disease modeling." @default.
- W2802907135 created "2018-05-17" @default.
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- W2802907135 date "2018-04-16" @default.
- W2802907135 modified "2023-10-16" @default.
- W2802907135 title "The Basics of Stem Cells and Their Utility as Platforms to Model Teratogen Action and Human Developmental and Degenerative Disorders" @default.
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- W2802907135 doi "https://doi.org/10.1002/9781119283249.ch1" @default.
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