FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2802912386> ?p ?o ?g. }

• W2802912386 endingPage "191" @default.
• W2802912386 startingPage "176" @default.
• W2802912386 abstract "Abstract Adoptive T-cell therapy, incorporating engineered T cell receptors (TCRs) or chimeric antigen receptors (CARs), target tumor antigens with high affinity and specificity. To increase the potency of adoptively transferred T cells, patients are conditioned with lymphodepleting chemotherapy regimens prior to adoptive T-cell transfer (ACT), and data suggest that fludarabine is an important component of an effective regimen. In a recent clinical trial using CAR-T cells engineered to target the CD19 B-cell antigen to treat acute lymphoblastic leukemia, JCAR-015 (NCT02535364), two patient deaths due to cerebral edema led to trial suspension. The lymphodepleting agent fludarabine was suggested as the causative agent, in part due to its known association with neurotoxicity and its ability to induce greater potency. In a similar CAR-T study also incorporating fludarabine in the preconditioning regimen, ZUMA-1 (NCT02348216), one patient died of cerebral edema. However, subsequent deaths in the JCAR-015 study after removal of fludarabine and improved understanding behind the mechanisms of CAR-T-related encephalopathy syndrome (CRES) indicate that fludarabine is not the primary causative agent of cerebral edema and that it can be safely incorporated into the preconditioning regimen for ACT. Since entering clinical use in the late 1980s as a chemotherapy agent, fludarabine and similar analogs have been associated with lethal neurological toxicity, yet the manifestation and timing of symptoms are distinct to those observed recently in ACT. Herein, we review the history of fludarabine development as a chemotherapeutic agent, and discuss the safety of its continued use in preconditioning regimens for ACT." @default.
• W2802912386 created "2018-05-17" @default.
• W2802912386 creator A5005426443 @default.
• W2802912386 creator A5015290004 @default.
• W2802912386 creator A5042255336 @default.
• W2802912386 creator A5052414597 @default.
• W2802912386 creator A5056610348 @default.
• W2802912386 creator A5087779758 @default.
• W2802912386 date "2018-05-07" @default.
• W2802912386 modified "2023-10-15" @default.
• W2802912386 title "Fludarabine and neurotoxicity in engineered T-cell therapy" @default.
• W2802912386 cites W1274344746 @default.
• W2802912386 cites W1459017742 @default.
• W2802912386 cites W1480670630 @default.
• W2802912386 cites W1521035635 @default.
• W2802912386 cites W1604141497 @default.
• W2802912386 cites W1607012924 @default.
• W2802912386 cites W1785340630 @default.
• W2802912386 cites W1803239093 @default.
• W2802912386 cites W1821172549 @default.
• W2802912386 cites W1855957336 @default.
• W2802912386 cites W1877911682 @default.
• W2802912386 cites W1881216623 @default.
• W2802912386 cites W1905059524 @default.
• W2802912386 cites W1935154669 @default.
• W2802912386 cites W1939111644 @default.
• W2802912386 cites W1963418965 @default.
• W2802912386 cites W1963522404 @default.
• W2802912386 cites W1966542058 @default.
• W2802912386 cites W1966738818 @default.
• W2802912386 cites W1969849446 @default.
• W2802912386 cites W1971037354 @default.
• W2802912386 cites W1972011758 @default.
• W2802912386 cites W1974692207 @default.
• W2802912386 cites W1983201885 @default.
• W2802912386 cites W1985770829 @default.
• W2802912386 cites W1990602451 @default.
• W2802912386 cites W1991664636 @default.
• W2802912386 cites W1993711476 @default.
• W2802912386 cites W1994301526 @default.
• W2802912386 cites W1995621823 @default.
• W2802912386 cites W1997608910 @default.
• W2802912386 cites W2000297273 @default.
• W2802912386 cites W2006176014 @default.
• W2802912386 cites W2010160231 @default.
• W2802912386 cites W2011197626 @default.
• W2802912386 cites W2013788041 @default.
• W2802912386 cites W2020312840 @default.
• W2802912386 cites W2027025310 @default.
• W2802912386 cites W2027703570 @default.
• W2802912386 cites W2029173845 @default.
• W2802912386 cites W2031311358 @default.
• W2802912386 cites W2032287795 @default.
• W2802912386 cites W2032835397 @default.
• W2802912386 cites W2039887904 @default.
• W2802912386 cites W2044657518 @default.
• W2802912386 cites W2048306988 @default.
• W2802912386 cites W2050302632 @default.
• W2802912386 cites W2051279163 @default.
• W2802912386 cites W2051549641 @default.
• W2802912386 cites W2055131118 @default.
• W2802912386 cites W2055963336 @default.
• W2802912386 cites W2057389857 @default.
• W2802912386 cites W2061473590 @default.
• W2802912386 cites W2062234112 @default.
• W2802912386 cites W2067650601 @default.
• W2802912386 cites W2068302119 @default.
• W2802912386 cites W2070193300 @default.
• W2802912386 cites W2070748533 @default.
• W2802912386 cites W2076740131 @default.
• W2802912386 cites W2076991609 @default.
• W2802912386 cites W2082708772 @default.
• W2802912386 cites W2092116640 @default.
• W2802912386 cites W2094652659 @default.
• W2802912386 cites W2098095232 @default.
• W2802912386 cites W2099570622 @default.
• W2802912386 cites W2104607069 @default.
• W2802912386 cites W2104729833 @default.
• W2802912386 cites W2105400883 @default.
• W2802912386 cites W2107456821 @default.
• W2802912386 cites W2107925822 @default.
• W2802912386 cites W2115750869 @default.
• W2802912386 cites W2116249739 @default.
• W2802912386 cites W2118796952 @default.
• W2802912386 cites W2124373740 @default.
• W2802912386 cites W2124446900 @default.
• W2802912386 cites W2127734125 @default.
• W2802912386 cites W2129702476 @default.
• W2802912386 cites W2130011407 @default.
• W2802912386 cites W2130037808 @default.
• W2802912386 cites W2130338247 @default.
• W2802912386 cites W2132836791 @default.
• W2802912386 cites W2132923173 @default.
• W2802912386 cites W2143044148 @default.
• W2802912386 cites W2145985838 @default.
• W2802912386 cites W2147328441 @default.
• W2802912386 cites W2148070164 @default.
• W2802912386 cites W2148387487 @default.

• next