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• W2802948170 endingPage "471" @default.
• W2802948170 startingPage "471" @default.
• W2802948170 abstract "In this review, we focus on the pathway of biogenesis of HDL, the essential role of apoA-I, ATP binding cassette transporter A1 (ABCA1), and lecithin: cholesterol acyltransferase (LCAT) in the formation of plasma HDL; the generation of aberrant forms of HDL containing mutant apoA-I forms and the role of apoA-IV and apoE in the formation of distinct HDL subpopulations. The biogenesis of HDL requires functional interactions of the ABCA1 with apoA-I (and to a lesser extent with apoE and apoA-IV) and subsequent interactions of the nascent HDL species thus formed with LCAT. Mutations in apoA-I, ABCA1 and LCAT either prevent or impair the formation of HDL and may also affect the functionality of the HDL species formed. Emphasis is placed on three categories of apoA-I mutations. The first category describes a unique bio-engineered apoA-I mutation that disrupts interactions between apoA-I and ABCA1 and generates aberrant preβ HDL subpopulations that cannot be converted efficiently to α subpopulations by LCAT. The second category describes natural and bio-engineered apoA-I mutations that generate preβ and small size α4 HDL subpopulations, and are associated with low plasma HDL levels. These phenotypes can be corrected by excess LCAT. The third category describes bio-engineered apoA-I mutations that induce hypertriglyceridemia that can be corrected by excess lipoprotein lipase and also have defective maturation of HDL. The HDL phenotypes described here may serve in the future for diagnosis, prognoses and potential treatment of abnormalities that affect the biogenesis and functionality of HDL." @default.
• W2802948170 created "2018-05-17" @default.
• W2802948170 creator A5009090914 @default.
• W2802948170 creator A5013442845 @default.
• W2802948170 creator A5043402089 @default.
• W2802948170 date "2017-01-01" @default.
• W2802948170 modified "2023-09-26" @default.
• W2802948170 title "Role of apolipoproteins, ABCA1 and LCAT in the biogenesis of normal and aberrant high density lipoproteins" @default.
• W2802948170 cites W1522065257 @default.
• W2802948170 cites W1556787858 @default.
• W2802948170 cites W1607399348 @default.
• W2802948170 cites W1956848161 @default.
• W2802948170 cites W1964556269 @default.
• W2802948170 cites W1965983458 @default.
• W2802948170 cites W1966609176 @default.
• W2802948170 cites W1968480475 @default.
• W2802948170 cites W1969668277 @default.
• W2802948170 cites W1971439798 @default.
• W2802948170 cites W1974744629 @default.
• W2802948170 cites W1974864595 @default.
• W2802948170 cites W1977597405 @default.
• W2802948170 cites W1977728730 @default.
• W2802948170 cites W1978921170 @default.
• W2802948170 cites W1983012279 @default.
• W2802948170 cites W1986439388 @default.
• W2802948170 cites W1987436224 @default.
• W2802948170 cites W1993028907 @default.
• W2802948170 cites W1994016991 @default.
• W2802948170 cites W1994483831 @default.
• W2802948170 cites W1999237392 @default.
• W2802948170 cites W2015389151 @default.
• W2802948170 cites W2016573134 @default.
• W2802948170 cites W2017922445 @default.
• W2802948170 cites W2020977463 @default.
• W2802948170 cites W2024616958 @default.
• W2802948170 cites W2031850888 @default.
• W2802948170 cites W2033299688 @default.
• W2802948170 cites W2039697717 @default.
• W2802948170 cites W2047330360 @default.
• W2802948170 cites W2048890665 @default.
• W2802948170 cites W2051560414 @default.
• W2802948170 cites W2054301035 @default.
• W2802948170 cites W2054489926 @default.
• W2802948170 cites W2056452930 @default.
• W2802948170 cites W2056472930 @default.
• W2802948170 cites W2057545989 @default.
• W2802948170 cites W2058148739 @default.
• W2802948170 cites W2063174765 @default.
• W2802948170 cites W2067963408 @default.
• W2802948170 cites W2071451946 @default.
• W2802948170 cites W2074239164 @default.
• W2802948170 cites W2077420019 @default.
• W2802948170 cites W2077760013 @default.
• W2802948170 cites W2080848089 @default.
• W2802948170 cites W2082653179 @default.
• W2802948170 cites W2084842911 @default.
• W2802948170 cites W2087782461 @default.
• W2802948170 cites W2088615805 @default.
• W2802948170 cites W2090375734 @default.
• W2802948170 cites W2091883388 @default.
• W2802948170 cites W2092273366 @default.
• W2802948170 cites W2099457911 @default.
• W2802948170 cites W2100342973 @default.
• W2802948170 cites W2100791808 @default.
• W2802948170 cites W2102129633 @default.
• W2802948170 cites W2102978920 @default.
• W2802948170 cites W2105658033 @default.
• W2802948170 cites W2107088295 @default.
• W2802948170 cites W2107459360 @default.
• W2802948170 cites W2108295152 @default.
• W2802948170 cites W2108744061 @default.
• W2802948170 cites W2109477850 @default.
• W2802948170 cites W2112187949 @default.
• W2802948170 cites W2113602208 @default.
• W2802948170 cites W2117622708 @default.
• W2802948170 cites W2120808705 @default.
• W2802948170 cites W2122457555 @default.
• W2802948170 cites W2123715983 @default.
• W2802948170 cites W2127432329 @default.
• W2802948170 cites W2127510556 @default.
• W2802948170 cites W2128006949 @default.
• W2802948170 cites W2128733938 @default.
• W2802948170 cites W2146619649 @default.
• W2802948170 cites W2149494472 @default.
• W2802948170 cites W2152561082 @default.
• W2802948170 cites W2159040091 @default.
• W2802948170 cites W2159836929 @default.
• W2802948170 cites W2161241326 @default.
• W2802948170 cites W2165906160 @default.
• W2802948170 cites W2167612600 @default.
• W2802948170 cites W2170654697 @default.
• W2802948170 cites W2189250426 @default.
• W2802948170 cites W2298719446 @default.
• W2802948170 cites W2334667221 @default.
• W2802948170 cites W2624367126 @default.
• W2802948170 cites W89468153 @default.
• W2802948170 doi "https://doi.org/10.7555/jbr.31.20160082" @default.
• W2802948170 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6307667" @default.

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